 | | Vol. 16.02 – 20 January, 2021 |
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| Scientists combined bulk RNA sequencing, single cell RNA sequencing, and bioinformatic analyses, including weighted gene co-expression analysis, to investigate the gene regulatory networks regulating human iPSC differentiation under chondrogenic conditions.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Deficiency of Vsnl1 not only reduced the beating rate of human iPSC-derived cardiomyocytes but also the heart rate of mice. Weighted gene co-expression network analysis unveiled the core gene regulation network governing the function of the sinoatrial node in mice.
[Nature Communications] |
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| Scientists used single-cell whole-genome transcriptional profiling and protein quantification to investigate the role of OCT4 in establishing pluripotency in the murine embryo.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators evaluated the mechanistic contributions of protein inhibitor of activated STAT-1 (PIAS1) in Huntington’s disease (HD) mice and HD patient-derived iPSCs and found a link between PIAS1 and DNA damage repair pathways.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists purified different cochlear cell types from neonatal mice, validated the composition of the different groups with single-cell RNA sequencing, and assessed the various groups’ potential to grow into inner ear organoids.
[Cell Reports] |
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| Researchers present a computational workflow that could identify transcription factors that were crucial for modulating pathways involved in cell lineage specification.
[Cell Death & Disease] |
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| Investigators generated iPSCs from a patient with FOXA2 haploinsufficiency followed by beta-cell differentiation to understand the role of FOXA2 during pancreatic beta-cell development.
[Cell Death & Disease] |
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| Glycosaminoglycans of endothelial cells derived from Moyamoya disease (MMD) and control iPSCs were analyzed. A computational fluid dynamics model was also developed to show the distribution of values for vascular wall shear stress in the predisposing region of MMD.
[Scientific Reports] |
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| Epithelial cell rests of malassez was cultured in ESC medium with 1 µM of 5-Azacytidine (5Aza), or 2 mM of valproic acid (Vpa), or a combination of 5Aza and Vpa. The cells stimulated with both 5Aza and Vpa were named as progenitor-dedifferentiated into stem-like cells.
[Scientific Reports] |
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| The authors focus on the current status of the development, application and manipulation of iPSC-derived platelet-like particles, which has been leading the field of regenerative medicine using iPSC-derived blood cells and has reached the first-in-human clinical trial.
[Cellular and Molecular Life Sciences] |
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| Scientists present a review focusing on studies that have used iPSCs for disease modeling and drug discovery in Niemann-Pick disease Type C1 (NPC1) and draw a comparison to commonly used NPC1 models.
[International Journal of Molecular Sciences] |
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| RheinCell Therapeutics GmbH announced it has received Good Manufacturing Practice certification and Manufacturing Authorization. This marks a landmark achievement for RheinCell, which is now among a select few iPSCs manufacturers to have received the critical certification.
[Lifescience Newswire] |
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| February 8 – 10, 2021
Virtual |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
| | | University of Luxembourg – Luxembourg City, Luxembourg |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Fondazione Human Technopole – Milan, Italy |
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