| Vol. 16.03 – 27 January, 2021 |
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| p53 reduction rescued axonal degeneration caused by poly(glycine-arginine), increased survival of C9orf72 amyotrophic lateral sclerosis/frontotemporal dementia-patient-iPSC-derived motor neurons, and mitigated neurodegeneration in a C9orf72 fly model. [Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed improved differentiation efficiency of T-cells from iPSCs derived from an antigen-specific cytotoxic T-cell clone, or from T-cell receptor-transduced iPSCs, as starting materials. [Nature Communications] |
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| Researchers screened for mutations in the receptor for Diphtheria Toxin (DT) which protect human cells from DT. [Nature Communications] |
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| The authors showed that microglia-secreted factors enhanced dopaminergic differentiation of somatic and iPSC-derived human neural stem cells. [Stem Cell Reports] |
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| Using small-angle X-ray scattering imaging, investigators showed that human iPSC-cardiomyocytes (hiPSC-CMs) matured and examined in a 3D environment exhibited a periodic spatial arrangement of the myofilament lattice, which had not been previously detected in hiPSC-CMs. [Microsystems & Nanoengineering] |
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| Researchers examined whether vinblastine could remove residual undifferentiated human iPSCs in human iPSC-derived intestinal epithelial cells (hiPSC-IECs), and attempted to generate hiPSC-IECs applicable to transplantation medicine. [Molecular Therapy-Methods & Clinical Development] |
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| Scientists performed detailed amino acid profiling and found that tryptophan (TRP) plays a key role in proliferation with maintaining pluripotency. They demonstrated TRP to be indispensable for survival and proliferation of human PSCs. [iScience] |
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| Using a CRISPR interference system in human ESCs, the authors describe a molecular characterization of the effects of downregulation of E-cadherin, one of the main initiation events of epithelial to mesenchymal transition, as a unique start signal. [Scientific Reports] |
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| Researchers report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons were cultured in extracellular matrix gel in a microfluidic platform. [Scientific Reports] |
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| Scientists explore the use of human-iPSCs to study prion-like protein propagation in neurodegenerative diseases, discuss advantages and limitations of this model, and present emerging technologies that, combined with the use of iPSC-based models, will provide powerful model systems to propel fundamental research forward. [Molecular Psychiatry] |
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| Twist Bioscience Corporation announced that its Twist Biopharma division has signed two licensing agreements with Serotiny and Applied StemCell (ASC). ASC supports gene editing and stem cell therapy development processes with two high-impact platforms: CRISPR and TARGATTâ„¢ genome editing and stem cell technologies. [Twist Bioscience Corporation] |
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| February 8 – 10, 2021 Virtual |
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| University of Utah – Salt Lake City, Utah, United States |
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| STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| University of Luxembourg – Luxembourg City, Luxembourg |
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| Queen Mary University of London – London, England, United Kingdom |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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