ESC & iPSC News Volume 16.03 | Jan 27 2021

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    2021-27-1 | ESC 16.03


    ESC & iPSC News by STEMCELL Technologies
    Vol. 16.03 – 27 January, 2021
    TOP STORY

    p53 Is a Central Regulator Driving Neurodegeneration Caused by C9orf72 poly(PR)

    p53 reduction rescued axonal degeneration caused by poly(glycine-arginine), increased survival of C9orf72 amyotrophic lateral sclerosis/frontotemporal dementia-patient-iPSC-derived motor neurons, and mitigated neurodegeneration in a C9orf72 fly model.
    [Cell]

    AbstractGraphical Abstract

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    PUBLICATIONSRanked by the impact factor of the journal

    A Clinically Applicable and Scalable Method To Regenerate T-Cells from iPSCs for Off-the-Shelf T-Cell Immunotherapy

    Scientists showed improved differentiation efficiency of T-cells from iPSCs derived from an antigen-specific cytotoxic T-cell clone, or from T-cell receptor-transduced iPSCs, as starting materials.
    [Nature Communications]

    Full Article

    Universal Toxin-Based Selection for Precise Genome Engineering in Human Cells

    Researchers screened for mutations in the receptor for Diphtheria Toxin (DT) which protect human cells from DT.
    [Nature Communications]

    Full Article

    Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells

    The authors showed that microglia-secreted factors enhanced dopaminergic differentiation of somatic and iPSC-derived human neural stem cells.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Probing the Subcellular Nanostructure of Engineered Human Cardiomyocytes in 3D Tissue

    Using small-angle X-ray scattering imaging, investigators showed that human iPSC-cardiomyocytes (hiPSC-CMs) matured and examined in a 3D environment exhibited a periodic spatial arrangement of the myofilament lattice, which had not been previously detected in hiPSC-CMs.
    [Microsystems & Nanoengineering]

    Full Article

    Vinblastine Treatment Decreases the Undifferentiated Cell Contamination of Human iPS Cell-Derived Intestinal Epithelial-Like Cells

    Researchers examined whether vinblastine could remove residual undifferentiated human iPSCs in human iPSC-derived intestinal epithelial cells (hiPSC-IECs), and attempted to generate hiPSC-IECs applicable to transplantation medicine.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells

    Scientists performed detailed amino acid profiling and found that tryptophan (TRP) plays a key role in proliferation with maintaining pluripotency. They demonstrated TRP to be indispensable for survival and proliferation of human PSCs.
    [iScience]

    AbstractGraphical Abstract

    Downregulation of E-adherin in Pluripotent Stem Cells Triggers Partial EMT

    Using a CRISPR interference system in human ESCs, the authors describe a molecular characterization of the effects of downregulation of E-cadherin, one of the main initiation events of epithelial to mesenchymal transition, as a unique start signal.
    [Scientific Reports]

    Full Article

    A Directional 3D Neurite Outgrowth Model for Studying Motor Axon Biology and Disease

    Researchers report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons were cultured in extracellular matrix gel in a microfluidic platform.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Current and Future Applications of Induced Pluripotent Stem Cell-Based Models to Study Pathological Proteins in Neurodegenerative Disorders

    Scientists explore the use of human-iPSCs to study prion-like protein propagation in neurodegenerative diseases, discuss advantages and limitations of this model, and present emerging technologies that, combined with the use of iPSC-based models, will provide powerful model systems to propel fundamental research forward.
    [Molecular Psychiatry]

    Abstract

    INDUSTRY AND POLICY NEWS

    Twist Bioscience Signs Two Biopharma Technology Agreements to Enable Novel Therapeutics Discovery

    Twist Bioscience Corporation announced that its Twist Biopharma division has signed two licensing agreements with Serotiny and Applied StemCell (ASC). ASC supports gene editing and stem cell therapy development processes with two high-impact platforms: CRISPR and TARGATTâ„¢ genome editing and stem cell technologies.
    [Twist Bioscience Corporation]

    Press Release

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    February 8 – 10, 2021
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    JOB OPPORTUNITIES

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    University of Utah – Salt Lake City, Utah, United States

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    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

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    University of Luxembourg – Luxembourg City, Luxembourg

    PhD Studentship – Bioengineering and Biotechnologies

    Queen Mary University of London – London, England, United Kingdom

    Research Technician – Stem Cell and Genome Editing

    The University of British Columbia – Vancouver, British Columbia, Canada

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