 | | Vol. 16.04 – 3 February, 2021 |
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| The authors showed that LIF-Stat3 signaling induced genomic hypomethylation via metabolic reconfiguration. Stat3−/− ESCs showed decreased α-ketoglutarate production from glutamine, leading to increased Dnmt3a and Dnmt3b expression and DNA methylation.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers introduced LMNA mutations from individuals with dilated cardiomyopathy into human (h)iPSCs and found that hiPSC-derived cardiomyocytes, in contrast to hepatocytes or adipocytes, exhibited aberrant nuclear morphology and specific disruptions in peripheral chromatin.
[Cell Stem Cell] |
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| Investigators describe a time-course single-cell-transcriptomic analysis of developing human stem cell-derived oligodendrocyte-lineage-cells.
[Nature Communications] |
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| Scientists bioprinted iPSC-derived cardiac microtissue models with spatially controlled cardiomyocyte and fibroblast cell ratios to replicate the structural and functional features of scarred cardiac tissue that arise following myocardial infarction, including reduced contractility and irregular electrical activity.
[Nature Communications] |
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| The authors constructed a complete single-cell landscape of early embryonic development of pig, considered one of the best host species for human organ generation, and systematically compared its epiblast development with that of human and monkey.
[Cell Discovery] |
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| Scientists demonstrated the generation of enterocyte-like cells by culturing human iPSC-derived intestinal progenitor cells on a collagen vitrigel membrane.
[Stem Cell Reports] |
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| The authors compared transcriptome and cellular phenotypes between telencephalic organoids and monolayers generated in parallel from three biologically distinct iPSC lines.
[Stem Cell Reports] |
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| Investigators analyzed the transcriptomic profiles of co-cultures of human iPSC-derived neurons and rat astrocytes, as well as one-day monocultures of human endothelial cells, cultured on microfluidic chips.
[Scientific Reports] |
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| Researchers identified salicylic diamines as potent agents exhibiting toxicity to murine and human PSCs but not to cardiomyocytes derived from them.
[Scientific Reports] |
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| An immune cell population enriched in inflamed gut tissue is shown to play a role in driving CD44+ intestinal organoid proliferation, while also regulating extracellular matrix deposition and remodeling in a synthetic hydrogel platform.
[Nature Materials] |
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| Scientists discuss current approaches to disc regeneration, with a particular focus on cell-based therapeutic strategies, including ongoing challenges, and attempts to provide a framework to interpret current data and guide future investigational studies.
[Nature Reviews Rheumatology] |
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| Investigators discuss recent findings linking chromatin dynamics to cell fate control. Specifically, chromatin undergoes a binary off/on switch during iPSC reprogramming, closing and opening loci occupied by somatic and pluripotency transcription factors, respectively.
[EMBO Reports] |
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| The authors discuss the current use of patient-specific iPSCs in identifying populations who are at risk to drug-induced cardiotoxicity and their potential applications in future precision medicine practice.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| Cellino, a personalized regenerative medicine company developing an automated process to generate autologous iPSCs at scale, has announced the closing of a $16M Seed financing round. The round was co-led by The Engine and Khosla Ventures, with participation from Humboldt Fund and 8VC.
[Cellino] |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | University of Utah – Salt Lake City, Utah, United States |
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| | University of Luxembourg – Luxembourg City, Luxembourg |
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| | Queen Mary University of London – London, England, United Kingdom |
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