| Vol. 16.05 – 10 February, 2021 |
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| Scientists generated complex, highly structured, 3D heart-forming organoids to study genetic defects in vitro. [Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers engineered human iPSCs to carry an inducible H3.3-K27M allele in the endogenous locus and studied the effects of the mutation in different disease-relevant neural cell types. [Cancer Cell] |
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| Investigators presented an authentic midbrain dopamine neuron derivation protocol based on a two-step WNT signaling activation strategy that improved expression of midbrain markers, such as Engrailed-1, while minimizing expression of contaminating posterior and anterior lineage markers. [Cell Stem Cell] |
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| Scientists combined iPSC and CRISPR-Cas9 technologies to develop a model of the clonal evolution of acute myeloid leukemia. [Cell Stem Cell] |
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| The authors developed a new approach to derive microglia from human (h)PSCs and built a defined hPSC-derived tri-culture system containing pure populations of hPSC-derived microglia, astrocytes, and neurons to dissect cellular cross-talk along the neuroinflammatory axis in vitro. [Nature Neuroscience] |
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| Scientists generated CRISPR/Cas9-engineered human PSCs with complete hemizygous SHANK3 deletion, the most common genetic abnormality in patients, and investigated the synaptic and morphological properties of SHANK3-deficient PSC-derived cortical neurons engrafted in the mouse prefrontal cortex. [Molecular Psychiatry] |
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| The authors describe a chemically defined differentiation protocol that generated all three sensory neuron subtypes from the same starting population, as well as methods to enrich for each individual subtype. [Stem Cell Reports] |
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| Investigators used the model of cardiomyocyte differentiation from mouse ESCs to elucidate the mechanisms for the mitochondrial damage in ESC-derived cardiomyocytes after knockdown of Rictor. [Acta Pharmacologica Sinica] |
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| Researchers determined whether combined transplantation of human iPSC-derived retinal precursor cells (RPC) and retinal pigment epithelial (RPE) cells was superior to RPE or RPC transplantation alone in preserving retinal from degeneration. [Molecular Therapy-Methods & Clinical Development] |
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| Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance and differentiation of naïve (n)PSCs. The authors report that self-renewal of nPSCs required minimal Sox2 expression. [iScience] |
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| A proportion of CLN3 in human, mouse, and iPSC-retinal pigment epithelium (RPE) cells localized to RPE microvilli, the site of photoreceptor outer segment (POS) phagocytosis. Furthermore, patient-derived CLN3 disease iPSC-RPE cells showed decreased RPE microvilli density and reduced POS binding and ingestion. [Communications Biology] |
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| Researchers developed a disease model using iPSC-derived cardiomyocytes from a healthy individual and two Myotonic Dystrophy type 1 patients with different CTG repeats lengths and clinical history. [Scientific Reports] |
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| Combining knowledge of epigenetics and PSCs is a promising avenue because epigenetic factors cooperate with eye field transcription factors to direct PSC fate – a foundation for congenital retinal disease modeling and cell therapy. [Trends in Molecular Medicine] |
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| One of the biggest challenges in drug development and personalized medicine is how to model the cellular microenvironment accurately. Cellaria and BioLamina are pursuing this challenge by collaborating to develop more defined reprogramming methods, large-scale iPSC expansions, and lineage differentiation for human cells and animal cells for vertebrate and non-vertebrate species. [Cellaria Inc. and BioLamina (Businesswire, Inc.)] |
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| April 12 – 14, 2021 Virtual |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| NCCR AntiResist – Basel, Switzerland |
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| University of Southern California – Los Angeles, California, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| University of Luxembourg – Luxembourg City, Luxembourg |
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