 | | Vol. 16.08 – 3 March, 2021 |
| |
|
|
| Scientists showed that the N6-methyladenosine (m6A) reader YT521-B homology-domain-containing protein 1 (YTHDC1) was required for the maintenance of mouse embryonic stem (ES) cells in an m6A-dependent manner, and that its deletion initiated cellular reprogramming to a 2C-like state.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers found that transcripts related to phosphodiesterase 4 (PDE4) signaling were significantly elevated in human cortical neurons differentiated from iPSCs with the disrupted-in-schizophrenia 1 (DISC1) mutation and that inhibition of PDE4 or activation of the cAMP signaling pathway functionally rescued synaptic deficits.
[Nature Communications] |
|
|
|
| Using patient-derived iPSCs and an in vitro artificial thymic organoid system as a model, investigators demonstrated that gene editing rescued the progressive T cell differentiation potential of RAG2-deficient cells to normal levels, with generation of a diversified T cell repertoire.
[Journal of Clinical Immunology] |
|
|
|
| Scientists showed that leukemia inhibitory factor alone in medium was sufficient for adaptation of two inhibitors/embryonic stem cells in a hypermethylated state.
[Stem Cell Reports] |
|
|
|
| Investigators mapped the genome-wide profiles of histone H3K4me3 and H3K27me3 in 2C-like cells. They found that the majority of genes in 2C-like cells inherited their histone status from embryonic stem cells.
[Stem Cell Reports] |
|
|
|
| Scientists tested if co-differentiation with mouse PSCs could accelerate the differentiation speed of hESCs. Following a six-week RNA-sequencing time course of neural differentiation, they identified 929 human genes that were upregulated earlier and 535 genes that exhibited earlier peaked expression profiles in chimeric cell cultures than in human cell cultures alone.
[PLoS Computational Biology] |
|
|
|
| Investigators developed cerebral organoids from iPSCs derived from human peripheral blood mononuclear cells and monitored mitochondrial health from the primary, reprogrammed and differentiated stages.
[Scientific Reports] |
|
|
|
| Researchers provided a mass spectrometry–based approach for simultaneous and quantitative monitoring of transcription factors, in an attempt to provide insight into their contributions in hESC differentiation.
[Analytical and Bioanalytical Chemistry] |
|
|
|
|
| The authors provide overview of the possible uses of cardiomyocytes and other cardiac cell types derived from hiPSC as in vitro models of heart in drug research.
[Pflugers Archiv-European Journal of Physiology] |
|
|
|
| Scientists present how the usage of iPSCs or hematopoietic stem cell master stocks and their stepwise differentiation toward natural killer (NK) cells represent a promising strategy in the current technological context of chimeric antigen receptor (CAR) cell‐based immunotherapies.
[Stem Cells Translational Medicine] |
|
|
|
|
| AgeX Therapeutics, Inc. and LyGenesis, Inc. announced that they will proceed to negotiate an agreement for a merger of the two companies.
[AgeX Therapeutics, Inc.] |
|
|
|
|
| March 29 – 30, 2021
Virtual |
|
|
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| | NCCR AntiResist – Basel, Switzerland |
|
|
|
| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
|
|
|
| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
|
|
|
| | University of Southern California – Los Angeles, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
