 | | Vol. 16.09 – 10 March, 2021 |
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| Scientists describe a strategy for directed differentiation of hPSCs into mature lung and airway epithelial cells obtained through maturation of NKX2.1+ hPSC-derived lung progenitors in a 3D matrix of collagen I in the absence of glycogen synthase kinase 3 inhibition.
[Nature Protocols] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers employed a combination of genetic screens in haploid ESCs, CRISPR/Cas9 gene disruption, large‐scale transcriptomics and computational systems biology to delineate the regulatory circuits governing naïve state exit.
[EMBO Journal] |
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| Investigators proposed that Npac is essential for transcriptional elongation of pluripotency genes by recruiting of p-TEFb and interacting with RNA Pol II Ser2 and Ser5.
[Genomics Proteomics & Bioinformatics] |
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| Researchers developed a simple method that could drive cultured hiPSC-derived cardiomyocytes (CMs) toward maturity across a number of phenotypes, with the aim of utilizing mature hiPSC-CMs to model human cardiovascular disease.
[Stem Cell Reports] |
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| Using a disease modeling approach, investigators showed that hiPSC‐derived müller glial cells could be used to model the features of diabetic retinopathy‐associated dyslipidemia.
[Glia] |
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| Scientists report the development of a novel assay, which they termed the PluriLum assay, where they have introduced a luciferase reporter gene into the locus of NKX2.5 of their hiPSC line.
[Archives of Toxicology] |
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| The iPSCs were used to model JAK2-mutated myeloproliferative neoplasms. Normal iPSCs underwent lentiviral transduction to overexpress JAK2p.V617F or JAK2p.N542_E543del (JAK2exon12) under a doxycycline-inducible system. The modified iPSCs were differentiated into erythroid cells.
[Scientific Reports] |
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| Researchers cocultured hiPSC-derived intestinal cells and fresh human hepatocytes which were isolated from PXB mice with medium circulation in a pneumatic-pressure-driven microphysiological systems with pipette-friendly liquid-handling options.
[Scientific Reports] |
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| Considering the fact that neurotrophins and their receptors play crucial roles in neural differentiation of ESCs, investigators sought to evaluate whether knockdown of Fndc5 decreased neural differentiation of mESCs by affecting the neurotrophins and their receptors expression.
[Human Cell] |
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| The authors consider the steps necessary to achieve predictive modelling of neurodegenerative disease with hiPSCs, using Huntington disease as an example.
[Nature Reviews Neurology] |
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| Kadimastem Ltd. announced that it has been granted a patent by The Israel Patent Office for its differentiated human astrocytes from human pluripotent stem cells for use in the treatment and drug screening of Amyotrophic Lateral Sclerosis (ALS).
[Kadimastem Ltd.] |
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| April 13 – May 11, 2021
Virtual |
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| | Gladstone Institute – San Francisco, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | NCCR AntiResist – Basel, Switzerland |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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