 | | Vol. 16.11 – 24 March, 2021 |
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| Researchers determined the therapeutic function of embryonic stem cell derived extracellular vesicles, specifically focusing on their role in immunomodulation after ischemic stroke.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed a longitudinal comparison of the transcriptomic profiles of three hiPSC lines that displayed differential myogenic specification, one robust and two blunted.
[Science Advances] |
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| Investigators describe a high yield approach for isolation and characterization of hESC-derived heart field specific and nodal-like cardiomyocytes.
[Cardiovascular Research] |
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| Scientists provide a simple method for the storage of neural stem cells as neurospheres at ambient temperature as an alternative method to more costly and inconvenient traditional methods of cryopreservation.
[Stem Cell Research & Therapy] |
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| The authors investigated the effect of human induced pluripotent stem cell-derived neural stem cells and umbilical cord-derived MSCs in a mouse model of acute spinal cord injury.
[Stem Cell Research & Therapy] |
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| To selectively label dopaminergic neurons and analyze mitochondrial morphology at the ultrastructural level, investigators generated control and PRKN-mutated patient tyrosine hydroxylase reporter iPSC lines.
[Molecular Brain] |
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| To clarify the function of PARP1 in hESCs, scientists report a PARP1 knockout hESC line, generated by CRISPR/Cas9 mediated gene targeting. This cell line showed normal karyotype, pluripotent stem cell marker expression and differentiation potential in vitro.
[Stem Cell Research] |
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| The authors established a novel and robust monolayer differentiation method to produce functional neural progenitor cells (NPC) from hESC/iPSCs on Type I Collagen. The derived cells not only displayed the requisite markers, but also behaved similarly to classic NPCs both in vitro and in vivo.
[Science China LIfe Sciences] |
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| hiPSCs were derived from a long QT syndrome type 2 (LQT2) patient carrying the Per-Arnt-Sim (PAS) domain variant hERG1-H70R. CRISPR/Cas9 gene editing produced isogenic control iPSC lines. Differentiated iPSC-derived cardiomyocytes were evaluated for their electrophysiology, hERG1a/1b mRNA expression, and hERG1a/1b protein expression.
[Circulation-Arrhythmia and Electrophysiology] |
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| Investigators developed a biomimetic approach to increase the binding affinity of the extracellular matrix for the class of heparin‐binding growth factors to localize and control the release of proangiogenic cues while maintaining their bioactivity.
[Journal of Biomedical Materials Research Part A] |
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| Investigators discuss recent progress in overcoming these hurdles that should facilitate the use of human induced pluripotent stem cells to develop new medicines and individualize therapies for heart disease.
[Cell Chemical Biology] |
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| Exacis Biotherapeutics Inc., announced several important steps in the preclinical development of its ExaNK™ engineered NK cell-therapy candidates.
[Exacis Biotherapeutics Inc. (PR Newswire LLC.)] |
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| April 19 – 23, 2021
Virtual |
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| | Gladstone Institute – San Francisco, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | NCCR AntiResist – Basel, Switzerland |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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