 | | Vol. 16.12 – 31 March, 2021 |
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| By incorporating iPSC-derived cells into a hydrogel-based extracellular matrix, researchers developed a 3D retinal pigment epithelium (RPE)- choriocapillaris (CC) model that recapitulated key features of both healthy and age-related macular degeneration/macular dystrophy eyes and provided modular control over RPE and CC layers.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report a post-translational mechanism that destabilized Polycomb Repressive Complex 2 (PRC2) to constrict H3K27me3 during lineage commitment.
[Nature Communications] |
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| The authors proposed that in addition to ataxia‐telangiectasia and Rad3 related (ATR), a MYBL2‐MRN‐ATM replication stress response pathway functioned in ESCs to control DNA replication initiation and prevent genome instability.
[EMBO Reports] |
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| Investigators suggest that transient receptor potential vanilloid 1 (TRPV1) activity was important for regulating the spontaneous activity of embryonic stem cell‐derived cardiomyocytes (ESC‐CMs) and revealed a novel interplay between TRPV1 and Na+/Ca2+ exchanger in regulating the physiological functions of ESC‐CMs.
[Journal of Cellular Physiology] |
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| Transplantation of hiPSC (human iPSC)-derived neural crest cells rapidly restored rabbit corneal thickness and clarity. However, the long-term recovery efficacy was impaired by the improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.
[Stem Cell Research & Therapy] |
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| The authors found that nuclear factor erythroid 2 p45-related factor 2 (NRF2) played an important role in the maturation of hiPSC (human iPSC)-derived cardiomyocytes.
[Stem Cell Research & Therapy] |
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| The authors generated two iPSC lines, ZNHi001-A and ZNHi001-B, from a prostate cancer patient carrying germline mutation in CHEK2 which might increase the risk of prostate cancer. Pluripotency and multi-lineage differentiation capacity of the two iPSC lines were confirmed by gene expression and teratoma assay.
[Stem Cell Research] |
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| Investigators demonstrated successful encapsulation, spheroid formation and high viability for three different hPSC lines. Using one of the hPSC lines they demonstrated maintenance of pluripotency and successful differentiation of stem cell spheroids into β-cells.
[Scientific Reports] |
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| Researchers compared two previously published protocols to obtain human induced pluripotent stem cell-derived striatal neurons from both healthy donors and Huntington’s disease patients.
[Scientific Reports] |
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| Scientists describe a protocol to generate cardiomyocytes, cardiac fibroblasts and cardiac endothelial cells, the three principal cell types in the heart, from human induced pluripotent stem cells and combine them in 3D cardiac microtissues.
[Nature Protocols] |
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| The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
[Biomedicine & Pharmacotherapy] |
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| FUJIFILM Cellular Dynamics, Inc. and Sana Biotechnology, Inc. announced that Sana has been granted a non-exclusive right to use FUJIFILM Cellular Dynamics’ iPSC platform for the development of commercial cell therapies.
[FUJIFILM Cellular Dynamics, Inc.] |
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| April 13 – May 11, 2021
Virtual |
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| | Beam Therapeutics – Cambridge, Massachusetts, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Gladstone Institute – San Francisco, California, United States |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| | NCCR AntiResist – Basel, Switzerland |
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