 | | Vol. 16.14 – 14 April, 2021 |
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| Scientists utilized an isogenic human induced pluripotent stem cell (hiPSC)-based system to demonstrate that conversion of APOE3 to APOE2 greatly reduced the production of amyloid-beta peptides in hiPSC-derived neural cultures.
[Molecular Psychiatry] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that centrosomes played an essential role in controlling axon formation in hiPSC‐derived neurons.
[EMBO Journal] |
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| Investigators explored the expanded potential stem cell (EPSC) technology for mammalian species refractory to the standard ESC approaches and report the successful establishment of bovine EPSCs from preimplantation embryos of both wild-type and somatic cell nuclear transfer.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors report a novel approach that produces, within ten days, the differentiation of human induced pluripotent stem cells into microglia by forced expression of both SPI1 and CEBPA.
[Stem Cell Reports] |
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| Researchers investigated how murine ESCs sense fluid shear stress and modulate a non‐canonical Wnt signaling response to promote pluripotency.
[Stem Cells] |
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| Scientists determined an appropriate in vitro doxorubicin dose that (a) eliminates residual undifferentiated stem cells before cell injection to prevent teratoma formation after cell transplantation and (b) does not cause cardiotoxicity in ESC-derived cardiomyocytes as demonstrated through contractility analysis, electrophysiology, topoisomerase activity assay, and quantification of reactive oxygen species generation.
[Experimental & Molecular Medicine] |
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| iPSCs were reprogrammed from peripheral blood mononuclear cells and megakaryocytes were derived from the iPSCs in 194 healthy European American and African American subjects. mRNA was isolated and gene expression measured by RNA sequencing. Protein expression was measured in 62 of the subjects using mass spectrometry.
[Journal of Thrombosis and Haemostasis] |
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| Researchers investigated substrate metabolism in hiPSC-CMs grown as a monolayer and in 3D, in porous collagen-derived scaffolds and in engineered heart tissue, by measuring rates of glycolysis and glucose and fatty acid oxidation, and changes in gene expression and mitochondrial oxygen consumption.
[Scientific Reports] |
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| Investigators revealed the selection criteria of the dissociation approach and coating matrix for replating iPSC-cardiomyocytes based on the maturity and the requirements of further applications.
[Experimental Cell Research] |
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| The authors discuss key features and development of the native vasculature, linking that to how hiPSC-derived vascular cells have been generated, the state of the art in vascular microphysiological systems, and opportunities arising from interdisciplinary thinking.
[Stem Cell Reports] |
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| Cytovia Therapeutics, Inc.announced that it has filed two provisional composition of matter patent applications for its FLEX-NK® platform, consisting of NKp46-based NK cell engager multifunctional antibodies targeting GPC3 for the treatment of solid tumors, including Hepatocellular carcinoma, and CD38 for the treatment of hematological malignancies, including Multiple Myeloma.
[Cytovia Therapeutics, Inc.] |
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| July 12 – 15, 2021
Virtual |
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| | Gladstone Institute – San Francisco, California, United States |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| | Insitro – South San Francisco, California, United States |
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| | Beam Therapeutics – Cambridge, Massachusetts, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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