ESC & iPSC News Volume 16.15 | Apr 21 2021

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    2021-04-21 | ESC 16.15


    ESC & iPSC News by STEMCELL Technologies
    Vol. 16.15 – 21 April, 2021
    TOP STORY

    Chimeric Contribution of Human Extended Pluripotent Stem Cells to Monkey Embryos Ex Vivo

    Scientists studied the chimeric competency of human extended pluripotent stem cells in cynomolgus monkey embryos cultured ex vivo.
    [Cell]

    Full ArticlePress Release

    Webinar: Advances in Human Brain Organoid Models
    PUBLICATIONSRanked by the impact factor of the journal

    Brain Cells Derived from Alzheimer’s Disease Patients Have Multiple Specific Innate Abnormalities in Energy Metabolism

    Researchers report that neural progenitor cells and astrocytes differentiated from late-onset Alzheimer’s disease patient-derived induced pluripotent stem cells exhibited multiple inter-related bioenergetic alterations.
    [Molecular Psychiatry]

    Full Article

    Disruption of the Blood−Brain Barrier in 22q11.2 Deletion Syndrome

    Scientists investigated whether the neuroimmune dysregulation vascular phenotype was intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome.
    [Brain]

    Full Article

    Identification of X-Chromosomal Genes That Drive Sex Differences in Embryonic Stem Cells through a Hierarchical CRISPR Screening Approach

    To identify the genetic basis of these sex differences, investigators used a two-step CRISPR screening approach to comprehensively identify X-linked genes that caused the female pluripotency phenotype in murine embryonic stem cells.
    [Genome Biology]

    Full Article

    In Vitro Model of Ischemic Heart Failure Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    hiPSCs were differentiated to functional hiPSC derived cardiomyocytes (hiPSC-CMs) and then purified using either a simulated ischemia media or by using magnetic antibody-based purification targeting the non-myocyte population for depletion from the cell population. Flow cytometry analysis confirmed that each purification approach generated hiPSC-CM cultures of >94% cTnT+ cells.
    [JCI Insight]

    Abstract

    Cues from Human Atrial Extracellular Matrix Enrich the Atrial Differentiation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Researchers examined the ability of powdered decellularized extracellular matrix to promote chamber-specific cardiac differentiation of hiPSCs.
    [Biomaterials Science]

    Full ArticleGraphical Abstract

    Hepatic Differentiation of Human Embryonic Stem Cells by Coupling Substrate Stiffness and Microtopography

    Investigators implied that the coupling of substrate stiffness and topography, combined with the biochemical signals, was favorable to improve the efficiency and functionality of hepatic differentiation of human ESCs.
    [Biomaterials Science]

    AbstractGraphical Abstract

    Induced Pluripotent Stem Cells from Subjects with Lesch-Nyhan Disease

    The authors described the development and characterization of six iPSC lines derived from three unrelated Lesch-Nyhan disease cases as a resource for future studies.
    [Scientific Reports]

    Full Article

    Sustained Intrinsic WNT and BMP4 Activation Impairs hESC Differentiation to Definitive Endoderm and Drives the Cells Towards Extra-Embryonic Mesoderm

    Scientists identified a hESC subline that fails to respond to the differentiation cues needed to obtain endoderm derivatives, differentiating instead into extra-embryonic mesoderm.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Directed Differentiation of Human Induced Pluripotent Stem Cells to Hepatic Stellate Cells

    Researchers describe a protocol to differentiate human induced pluripotent stem cells into hepatic stellate cells.
    [Nature Protocols]

    Abstract

    Harnessing Pluripotent Stem Cells as Models to Decipher Human Evolution

    The authors provide a comprehensive overview of how the seemingly unlikely combination of iPSCs and explicit evolutionary frameworks are transforming what is possible in our understanding of humanity’s past and present.
    [FEBS Journal]

    Abstract

    INDUSTRY AND POLICY NEWS

    The Wake Forest Institute for Regenerative Medicine Joins the Coalition for the Advancement of Research and Innovation in Trauma

    The Coalition for the Advancement of Research and Innovation in Trauma announced the addition of The Wake Forest Institute for Regenerative Medicine to its group of organizations whose mission is to establish the government coordination and funding necessary to enable greater innovation in trauma, acute care, emergency and pre-hospital care.
    [The Coalition for the Advancement of Research and Innovation in Trauma (PR Newswire LLC.)]

    Press Release

    FEATURED EVENT

    World Stem Cell Summit

    June 14 – 18, 2021
    Virtual

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    JOB OPPORTUNITIES

    Research Associate – Neurodevelopmental Disorders

    McGill University – Montreal, Quebec, Canada

    Postdoctoral Fellow – Genomics of Endocrine Traits

    Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States

    Research Associate – Disease Modeling

    Insitro – South San Francisco, California, United States

    Research Scientist – Liver

    Beam Therapeutics – Cambridge, Massachusetts, United States

    Postdoctoral Fellow Position – Neurological Diseases

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    > See All Jobs

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