| Vol. 16.15 – 21 April, 2021 |
| |
|
|
| Scientists studied the chimeric competency of human extended pluripotent stem cells in cynomolgus monkey embryos cultured ex vivo. [Cell] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers report that neural progenitor cells and astrocytes differentiated from late-onset Alzheimer’s disease patient-derived induced pluripotent stem cells exhibited multiple inter-related bioenergetic alterations. [Molecular Psychiatry] |
|
|
|
| Scientists investigated whether the neuroimmune dysregulation vascular phenotype was intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome. [Brain] |
|
|
|
| To identify the genetic basis of these sex differences, investigators used a two-step CRISPR screening approach to comprehensively identify X-linked genes that caused the female pluripotency phenotype in murine embryonic stem cells. [Genome Biology] |
|
|
|
| hiPSCs were differentiated to functional hiPSC derived cardiomyocytes (hiPSC-CMs) and then purified using either a simulated ischemia media or by using magnetic antibody-based purification targeting the non-myocyte population for depletion from the cell population. Flow cytometry analysis confirmed that each purification approach generated hiPSC-CM cultures of >94% cTnT+ cells. [JCI Insight] |
|
|
|
| Researchers examined the ability of powdered decellularized extracellular matrix to promote chamber-specific cardiac differentiation of hiPSCs. [Biomaterials Science] |
|
|
|
| Investigators implied that the coupling of substrate stiffness and topography, combined with the biochemical signals, was favorable to improve the efficiency and functionality of hepatic differentiation of human ESCs. [Biomaterials Science] |
|
|
|
| The authors described the development and characterization of six iPSC lines derived from three unrelated Lesch-Nyhan disease cases as a resource for future studies. [Scientific Reports] |
|
|
|
| Scientists identified a hESC subline that fails to respond to the differentiation cues needed to obtain endoderm derivatives, differentiating instead into extra-embryonic mesoderm. [Scientific Reports] |
|
|
|
|
| Researchers describe a protocol to differentiate human induced pluripotent stem cells into hepatic stellate cells. [Nature Protocols] |
|
|
|
| The authors provide a comprehensive overview of how the seemingly unlikely combination of iPSCs and explicit evolutionary frameworks are transforming what is possible in our understanding of humanity’s past and present. [FEBS Journal] |
|
|
|
|
| The Coalition for the Advancement of Research and Innovation in Trauma announced the addition of The Wake Forest Institute for Regenerative Medicine to its group of organizations whose mission is to establish the government coordination and funding necessary to enable greater innovation in trauma, acute care, emergency and pre-hospital care. [The Coalition for the Advancement of Research and Innovation in Trauma (PR Newswire LLC.)] |
|
|
|
|
| June 14 – 18, 2021 Virtual |
|
|
|
|
|
| McGill University – Montreal, Quebec, Canada |
|
|
|
| Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
|
|
|
| Insitro – South San Francisco, California, United States |
|
|
|
| Beam Therapeutics – Cambridge, Massachusetts, United States |
|
|
|
| University of Alabama at Birmingham – Birmingham, Alabama, United States |
|
|
|
|