 | | Vol. 16.16 – 28 April, 2021 |
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| Researchers differentiated hPSCs into pancreatic duct-like organoids with morphological, transcriptional, proteomic, and functional characteristics of human pancreatic ducts, further maturing upon transplantation into mice.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists devised enhanced conditions that enabled stabilization of hPSCs with stringent naive functional and molecular properties while preserving cell-autonomous differentiation competence into embryonic, germ cell and extra-embryonic lineages.
[Cell Stem Cell] |
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| The authors report that YTHDC1 played indispensable roles in the self-renewal and differentiation potency of mouse ESCs, which highly depended on the m6A-binding ability.
[Protein & Cell] |
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| Investigators found that X chromosome inactivation erosion in iPSCs caused a remodeling of the proteome, affecting the expression of a much wider range of proteins and disease-linked loci than previously realized.
[Cell Reports] |
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| Researchers report an in vitro mild traumatic brain injury modeling system based on 3D cultured human iPSC derived neural progenitor cells to evaluate consequences of single and repetitive mild traumatic brain injury using a 3D printed mini weight‐drop impact device.
[Advanced Healthcare Materials] |
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| Investigators report on a novel, simplified differentiation method for forming functional osteoclasts from hiPSCs.
[Journal of Bone and Mineral Research] |
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| Using patient-derived iPSC neurons expressing a tau aggregation biosensor, researchers developed a cell culture system that allowed continuous assessment of both induced tau aggregation and neuronal viability at single-cell resolution for periods of >1 week.
[Journal of Neuroscience] |
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| The authors developed the Paint Raman Express Spectroscopy System, which used two fast-rotating galvano mirrors to obtain spectra from a wide area of a cell.
[Scientific Reports] |
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| Scientists describe a series of experiments to determine whether derivation of ESC could be generated by replacing IWR-1 with other inhibitors of WNT signaling.
[Biology of Reproduction] |
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| The authors review which transcription factors and signaling pathways play a role in both maintenance of pluripotency as well as cell cycle progression.
[Cellular and Molecular Life Sciences] |
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| CARISMA Therapeutics Inc. announced it has established a multi-year scientific collaboration with Bruce Blazar, MD, Regents Professor of Pediatrics, Division of Blood and Marrow Transplantation and Cellular Therapy at the University of Minnesota to investigate and develop allogeneic macrophage therapies.
[CARISMA Therapeutics (PR Newswire LLC.)] |
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| January 12 – 14, 2022
Shanghai, China |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Insitro – South San Francisco, California, United States |
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| | Beam Therapeutics – Cambridge, Massachusetts, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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Cancer Stem Cell News
Cell Therapy News
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Pancreatic Cell News
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