ESC & iPSC News Volume 16.17 | May 5 2021

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    ESC 16.17 | May 5 2021


    ESC & iPSC News by STEMCELL Technologies
    Vol. 16.17 – 5 May, 2021
    TOP STORY

    Global miRNA Dosage Control of Embryonic Germ Layer Specification

    Alternative transcription initiation occurs downstream of a stem-loop in DGCR8 mRNA to bypass an autoregulatory feedback loop during mouse ESC differentiation.
    [Nature]

    Abstract

    Explore scientific events this May with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells

    The authors deployed high-throughput screening strategies to identify a small-molecule cocktail that improved viability of hPSCs and their differentiated progeny.
    [Nature Methods]

    Full Article

    Suppressing the DSCAM/PAK1 Pathway Reverses Neurogenesis Deficits in Down Syndrome Patient iPSC-Derived Cerebral Organoids

    Researchers performed histological assays and unbiased single-cell RNA sequencing analysis on cerebral organoids derived from four euploid cell lines and from iPSCs to explore cell type-specific abnormalities associated with Down syndrome during early brain development.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    iPSC-Derived Myelinoids to Study Myelin Biology of Humans

    Scientists developed human iPSC-derived myelinating organoids and quantitative tools to study myelination from oligodendrogenesis through to compact myelin formation and myelinated axon organization.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Cooperation between HDAC3 and DAX1 Mediates Lineage Restriction of Embryonic Stem Cells

    Investigators identified the mechanism of a barrier and reported that the histone deacetylase Hdac3 and the transcriptional corepressor Dax1 cooperatively limited the lineage repertoire of mESCs by silencing an enhancer of the extraembryonic endoderm‐specifying transcription factor Gata6.
    [EMBO Journal]

    AbstractGraphical Abstract

    Inhibition of Syk Promotes Chemical Reprogramming of Fibroblasts via Metabolic Rewiring and h2s Production

    Researchers identified Syk‐Cn‐NFAT signaling axis as a new barrier of chemical reprogramming and suggested metabolic rewiring and redox homeostasis as important opportunities for controlling cell fates.
    [EMBO Journal]

    AbstractGraphical Abstract

    Expression Levels and Activation Status of Yap Splicing Isoforms Determine Self-Renewal and Differentiation Potential of Embryonic Stem Cells

    Scientists identify two Yap splicing isoforms, which showed equal expression levels but heterogeneous distribution in ESCs.
    [Stem Cells]

    Abstract

    Patient-Specific induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells as a Model to Study Autosomal Recessive Hypercholesterolemia

    Investigators aimed to validate patient-specific iPSC-derived hepatocyte-like cells as an appropriate tool to model autosomal recessive hypercholesterolemia disease.
    [Stem Cells and Development]

    Abstract

    Watch Video Recordings from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Stem Cell Neurodevelopmental Solutions for Restorative Treatments of the Human Trunk and Spine

    New models of posterior embryo development identify neuromesodermal progenitors as a major bifurcation point in generating the spinal cord and somites and is leading to production of cell types with the full range of axial identities critical for repair of trunk and spine disorders. This is coupled with organoid technologies including assembloids, circuitoids, and gastruloids.
    [Frontiers in Cellular Neuroscience]

    Full Article

    Modeling Precision Cardio-Oncology: Using Human-Induced Pluripotent Stem Cells for Risk Stratification and Prevention

    Scientists synthesize evidence illustrating how common cancer therapeutic agents, such as anthracyclines, human epidermal growth factors receptors monoclonal antibodies, and tyrosine kinase inhibitors, have been evaluated in cardiomyocytes derived from human-iPSC to understand the underlying mechanisms of cardiovascular toxicity.
    [Current Oncology Report]

    Full Article

    INDUSTRY AND POLICY NEWS

    Hope Bio’s Stem Cells to Be Used in Fight against Parkinson’s

    Hope Biosciences Stem Cell Research Foundation received FDA authorization for a Phase II clinical trial to assess the efficacy and safety of multiple intravenous infusions of autologous adipose-derived MSCs in improving activities of daily living and quality of life in subjects with Parkinson’s Disease.
    [Hope Biosciences Stem Cell Research Foundation]

    Press Release

    FEATURED EVENT

    The American Association for Cancer Research (AACR) Annual Meeting 2021: Week 2

    May 17 – 21, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Senior Scientific Editor – Cell Stem Cell

    Elsevier – Cambridge, Massachusetts, United States

    Postdoctoral Researcher – Cell Fate Engineering

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Fellow – Stem Cell Differentiation

    NYU Langone Medical Center – New York, New York, United States

    Research Associate – Primate Retinal Disease

    Oregon Health & Science University – Portland, Oregon, United States

    Research Associate – Disease Modeling

    Insitro – South San Francisco, California, United States

    > See All Jobs

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