 | | Vol. 16.18 – 12 May, 2021 |
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| Researchers report the generation of arcuate organoids from human iPSCs to model the development of the human hypothalamic arcuate nucleus.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors generated a patient-specific iPSC line from a family cohort carrying a hereditary atrial septal defect (ASD) mutation in GATA4 gene, as well as a hESC line carrying the isogenic T280M mutation using the CRISPR/Cas9 genome editing method. The GATA4-mutant iPSCs and ESCs were then differentiated into cardiomyocytes to model GATA4 mutation-associated ASD.
[Cardiovascular Research] |
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| Researchers showed that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8+ T cell effector and memory responses, induced cancer-specific humoral immune responses, reduced immunosuppressive CD4+ T regulatory cells, and prevented tumor formation in 75% of pancreatic ductal adenocarcinoma mice.
[Stem Cell Reports] |
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| Scientists showed that retinoic acid had a broader role in 2C‐like cells state, not only was one of the upstream regulators of the 2C‐like state in chemically defined media but also illuminated genetic and epigenetic regulations that govern ESCs to 2C‐like transition.
[Cell Proliferation] |
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| Researchers found that disruption of glyoxalase I, the gene encoding a major catabolic enzyme scavenging the carbonyl group, increased vulnerability to external carbonyl stress, leading to abnormal phenotypes in hiPSCs.
[Translational Psychiatry] |
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| The KCNH2 was knocked out in the hESC H9 line using the CRISPR/Cas9 system. Using a chemically defined differentiation protocol, investigators obtained and verified human ether-a-go-go-related gene(hERG)-deficient cardiomyocytes. Subsequently, high-throughput microelectrode array assays and drug interventions were performed to characterise the electrophysiological signatures of hERG-deficient cell lines.
[Stem Cell Research & Therapy] |
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| Scientists identified a homozygous stop-gain mutations in DSG2 that led to complete desmoglein-2 deficiency in a patient with severe biventricular heart failure. Induced pluripotent stem cells were generated from the patient, and the mutated DSG2 gene locus was heterozygously corrected to a normal allele via homology-directed repair.
[Human Molecular Genetics] |
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| To interrogate the C-mannosylome of hiPSCs, researchers compared the secretomes of CRISPR-Cas9 mutants lacking either the C-mannosyltransferase DPY19L1 or DPY19L3 to wild-type hiPSCs using mass spectrometry-based quantitative proteomics.
[Molecular & Cellular Proteomics] |
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| Scientists established human embryonic stem cells carrying this variant using CRISPR/Cas9 methods and found that the level of CHD7 mRNA significantly decreased compared to control.
[Neuroscience Bulletin] |
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| The authors present the latest technical developments and discuss how bioengineering can further advance the optimization and external control of stem cell-based embryo-like structures.
[Stem Cell Reports] |
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| MIMEDX Group, Inc. announced a collaborative agreement with the Wake Forest Institute for Regenerative Medicine to develop and advance scientific evidence in support of safe and effective clinical therapies. The partnership reflects a shared vision to advance regenerative science and innovative biologics that restore quality of life for patients, and is geared to further understanding product mechanisms of action and potential therapeutic targets.
[MIMEDX Group, Inc.] |
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| January 12 – 14, 2022
Shanghai, China |
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| | National Institutes of Health – Rockville, Maryland, United States |
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| | National Institutes of Health – Rockville, Maryland, United States |
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| | Elsevier – Cambridge, Massachusetts, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | NYU Langone Medical Center – New York, New York, United States |
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