 | | Vol. 16.23 – 16 June, 2021 |
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| To determine the impact of copy number variation at the 1q21.1 locus on neuronal development, researchers generated iPSCs from individuals harbouring 1q21.1 deletion or duplication and differentiated them into functional cortical neurons.
[Molecular Psychiatry] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The engineered FailSafeTM human PSCs demonstrated robust ventral midbrain specification in vitro, capable of forming neural grafts upon transplantation.
[Nature Communications] |
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| Scientists demonstrated that the transcription factor E2F6, a member of the polycomb repressive complex 1.6, was critical to target and initiate epigenetic silencing at germline genes in early embryogenesis.
[Nature Communications] |
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| The authors reported that MEK1/2 inhibitors could be replaced during maintenance of naive human pluripotency by inhibitors targeting either upstream or downstream kinases. Naive human ESCs maintained under these alternative conditions displayed elevated levels of ERK phosphorylation but retained genome-wide DNA hypomethylation and a transcriptional identity of the pre-implantation epiblast.
[Cell Reports] |
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| Investigators used a polymer-Brn2, Ascl1, Myt1l factor transfection polypex to reprogram primary mouse embryonic fibroblasts. Using a multiarchitecture chip, they screened for patterns that may improve transfection and/or subsequent induced neuron reprogramming efficiency.
[Biomaterials Science] |
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| Researchers analyzed the influence of the in vitro environment on the induction of porcine iPSCs differentiation into primordial germ cell-like cells, providing a suitable in vitro model for use in translational studies and to help answer numerous remaining questions about germ cells.
[Stem Cell Reviews and Reports] |
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| Cell line derivation, its propagation and storage of the human embryonic stem cell line, KthES11, were performed without feeders in an animal product-free environment according to current Good Manufacturing Practice standards.
[Stem Cell Research] |
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| Scientists established a human isogenic cell line panel based on Down syndrome-specific iPSCs, the XIST-mediated transcriptional silencing system in trisomic chromosome 21, and genome/chromosome-editing technologies to eliminate phenotypic fluctuations caused by genetic variation.
[Communications Biology] |
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| Investigators found that let-7c, miR-26b-5p, −29c-3p, −148a-3p, −196a-5p, −199b-5p and −374a-5p were suppressed in iPSC-derived fibroblasts in vitro and in 3D dermis-like self-assembly tissue, whereas their corresponding targets involved in cellular migration were upregulated.
[Experimental Dermatology] |
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| Researchers cultured iPSC-derived excitatory neurons in 3D precast hydrogel plates and compared their maturation to 2D monolayer cultures.
[Journal of Neuroscience Methods] |
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| Investigators discuss the roles of the structural components of Oct proteins in reprogramming and how donor cell epigenomes endow Oct proteins with different reprogramming competences.
[Experimental & Molecular Medicine] |
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| Scientists discuss the common properties of cancer stem cells (CSCs) and PSCs, and highlight the potential of PSCs in cancer studies, therapeutic applications, as well as educating the immune system against CSCs.
[Stem Cell Reviews and Reports] |
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| The author provides background information on hirschsprung (HSCR) disease, outlines the future approaches of stem cell-based HSCR therapy, reviews recent key publications, and discusses technical and ethical challenges the field faces prior to clinical translation.
[Gene Therapy] |
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| Shoreline Biosciences, Inc. and BeiGene, Ltd. announced a worldwide collaboration to develop and commercialize a portfolio of NK-based cell therapeutics with Shoreline’s iPSC NK cell technology and BeiGene’s research and clinical development capabilities for different malignancies.
[nan] |
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| Heartseed, Inc. announced it has raised approx. $37 Million at Series C round. These funds will accelerate the initiation of a global clinical trial of HS-001, an allogeneic iPSC-derived, highly purified ventricular cardiomyocyte spheroids for heart failure.
[Heartseed, Inc.] |
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| July 12 – 16, 2021
Virtual |
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| | Stanford University – Stanford, California, United States |
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| | Sana Biotechnology – Seattle, Washington, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | University of Oslo – Oslo, Norway |
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| | University of Pisa – Pisa, Italy |
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