 | | Vol. 16.26 – 7 July, 2021 |
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| Scientists combined single-molecule footprinting with interaction proteomics to identify BTG3-associated nuclear protein (BANP) as the transcription factor that bound this element in mouse and human genomes.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers introduced sci-Space, which retained single-cell resolution while resolving spatial heterogeneity at larger scales. Applying sci-Space to developing mouse embryos, they captured approximate spatial coordinates and whole transcriptomes of about 120,000 nuclei.
[Science] |
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| Investigators described a protocol for generating mouse–human chimeric embryos by injecting naive human PSCs converted from the primed state.
[Nature Protocols] |
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| The authors investigated mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to identify commonalities in glial pathobiology across species and models.
[Cell Reports] |
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| ESCs were cultured and induced differentiation to pacemaker-like cells. RNA sequencing was used to identify the differential expression long non-coding RNAs during the differentiation of ESCs into pacemaker-like cells.
[Cell Death & Disease] |
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| Researchers optimized a protocol to generate chemically defined human iPSC-derived mesodermal progenitors and demonstrated that these cells contributed to myotube formation and differentiated into cardiomyocytes.
[Cell Death & Disease] |
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| PRC1.6, a non-canonical PRC1, is known to function as a safeguard preventing precocious and ectopic onset of meiosis in germ cells and ESCs, respectively. Scientists characterized MGA, one of the essential components of the complex, to help uncover the detailed molecular bases of PRC1.6 function.
[Stem Cells] |
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| The authors investigated whether the co-culture of ESCs with HEI-OC1 cells promoted differentiation. Dissociated or embryonic bodies of ESCs were introduced to a conditioned and inactivated confluent layer of HEI-OC1 cells for 14 days.
[Scientific Reports] |
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| To study the relationship between DMR methylation and imprinted gene expression, investigators differentiated wild-type and Zfp57-/- hybrid mouse ESCs into neural precursor cells and evaluated allelic expression of imprinted genes.
[Scientific Reports] |
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| Researchers characterized the cellular expression and localization patterns of pyruvate kinase muscle isoforms in mouse ESCs, chemically transitioned epiblast-like cells (mEpiLCs) representing formative pluripotency, and mEpiSCs using immunoblotting and confocal microscopy.
[Experimental Cell Research] |
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| Scientists found that the plant hormone abscisic acid could increase the generation of megakaryocytes and platelets from human iPSCs.
[Platelets] |
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| The authors outline the current progress towards fully PSC-derived in vitro co-culture models of the human neuromuscular junction and discuss future directions and challenges that must be overcome in order to create reproducible fully PSC-derived models that can be used for developmental studies, disease modeling, and drug testing.
[Stem Cell Reviews and Reports] |
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| JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and multipotent stem cells. Investigators discuss the recent advances of JMJD3 function in stem cell fate.
[Cell Communication and Signaling] |
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| Researchers from the University of Sydney have been awarded $6.3 million for three projects which will address stem cell derived-retinal organoids for blindness in adults, iPSC derived cardiomyocytes for chronic heart failure, and help to improve decisions about access to stem cell interventions.
[The University of Sydney] |
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| August 23 – September 2, 2021
Virtual |
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| | Stanford University – Palo Alto, California, United States |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Stanford University – Palo Alto, California, United States |
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| | FibroBiologics – Houston, Texas, United States |
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