 | | Vol. 16.28 – 21 July, 2021 |
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| Researchers developed culture conditions to recreate the stepwise differentiation process from pluripotent cells to fetal ovarian somatic cell–like cells, providing a method for in vitro oocyte production and follicle generation for a better understanding of mammalian reproduction.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| p53 activation convergently evolved to couple p53 to double homeobox (Dux)/DUX4 activation in ESCs, embryos and cells from patients with facioscapulohumeral muscular dystrophy (FSHD), potentially uniting the developmental and disease regulation of DUX-family factors and identifying evidence-based therapeutic opportunities for FSHD.
[Nature Genetics] |
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| Scientists showed that the chromatin and 3D structural features of poised enhancers were conserved among mouse PSCs both in vitro and in vivo.
[Nature Communications] |
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| Investigators developed a gene-editing approach that replaced the entire mutant open reading frame with the wild-type sequence to universally correct all fukutin-related protein (FKRP) mutations and applied this approach to correct FKRP mutations in iPSCs derived from patients displaying broad clinical severity.
[Cell Reports] |
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| The authors provided systematic theoretical guidance for optimizing the iPSCs-derived red blood cells differentiation system, which was a useful model for simulating in vivo hematopoietic development and differentiation.
[Genomics Proteomics & Bioinformatics] |
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| Using LMX1A-eGFP knock-in reporter human ESCs, scientists discovered a novel surface antigen, trophoblast glycoprotein, which was preferentially expressed in ventral mesencephalic dopaminergic precursors.
[npj Parkinson’s Disease] |
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| Using mouse ESCs (mESCs) to recapitulate murine embryonic development, the researchers studied the requirement for Notch signaling during the earliest B-lymphopoiesis and found that Rbpj-deficient mESCs were able to generate B-1 cells.
[Development] |
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| The authors investigated whether ESCs retained memory of their previous states or transition in a memoryless (Markovian) process, and showed that some highly dynamic lineages of ESCs did not exhibit the Markovian property: their previous states and kin relations influenced future choices.
[iScience] |
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| The potential effect of fludioxonil on cardiac differentiation was evaluated in mouse ESCs. Exposure to fludioxonil resulted in reduced size of mouse embryoid bodies and induced increasing expression levels of the pluripotency markers Oct4, Sox2 and Nanog.
[Reproductive Toxicology] |
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| Investigators evaluated changes in extracellular vesicles morphology, concentration, and miRNA and protein expression in culture supernatants during the differentiation of iPSCs into neural lineage cells, for application in regenerative medicine for Parkinson’s disease.
[Journal of Bioscience and Bioengineering] |
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| Recent studies have indicated that stem cell behaviour is strongly coupled to the regulation of protein synthesis by the ribosome. The authors discuss how different translation mechanisms control the function of adult and ESCs.
[Nature Reviews Molecular Cell Biology] |
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| Vyant Bio, Inc. announced that its wholly-owned subsidiary, StemoniX, Inc. was issued US Patent No. 11054408, titled “High Throughput Optical Assay of Human Mixed Cell Population Spheroids” by the United States Patent and Trademark Office.
[Vyant Bio, Inc.] |
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| September 1 – 3, 2021
Virtual |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University of Wisconsin–Madison – Madison, Wisconsin, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Heinrich Heine University – Dusseldorf, Germany |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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