| Vol. 16.32 – 18 August, 2021 |
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| Scientists reported the successful generation of trophoblast stem cells (TSCs) from primed human PSCs (hPSCs) and showed that BMP4 substantially enhanced this process. TSCs derived from primed hPSCs were similar to blastocyst-derived human TSCs in terms of morphology, proliferation, differentiation potential, and gene expression. [Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported a novel role for Chd1 in protecting genome integrity at promoter regions by preventing DNA double-stranded break accumulation in ESCs. [Nature Communications] |
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| Investigators generated deeply sequenced Hi-C data for human PSCs that allowed them to identify CTCF loop domains that had highly conserved boundary CTCF sites and showed a notable enrichment of individual developmental regulators. [Nature Communications] |
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| The authors demonstrated that human PSC fate was coupled to mechanical cues imposed by neighboring cells and revealed that hijacking this mechanism allowed variants to achieve clonal dominance in cultures. [Developmental Cell] |
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| Researchers examined the antitumor effects of EWS/FLI1-rejuvenated cytotoxic T lymphocytes against Ewing sarcoma. The altered amino acid sequence at the break/fusion point of EWS/FLI1, when presented as a neoantigen, evoked an immune response that targeted EWS/FLI1+ sarcoma. [Cancer Immunology Research] |
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| The regulated spatially homogeneous chondrogenic microenvironment around the human iPSC-derived pellet in the perichondrium-inspired permeable nanofibrous tube well remarkably improved the quality of the differentiated pellet toward a more hyaline-like cartilage pellet. [Biofabrication] |
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| Scientists used genetic engineering to create human PSCs in which the majority of the polymorphic human leukocyte antigens, the main drivers of allogeneic rejection, were deleted. [Cell Reports] |
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| Investigators established conditions to differentiate human PSCs into yolk sac-like cells that resembled the post-implantation human hypoblast molecularly and functionally. [eLife] |
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| Researchers reported that the conjunct activity of two orphan nuclear receptors, Esrrb and Nr5a2, paralleled the importance of that of Oct4 and Sox2 in naïve ESCs. [Development] |
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| The authors presented a methodology for direct differentiation of the CRISPR-targeted cell pools, using a doxycycline-inducible Cas9 expressing human iPSC line for high efficiency editing to eliminate the laborious clonal line generation steps. [Scientific Reports] |
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| Scientists prepared cartilage from human iPSCs (hiPS-Cart) in a scaffoldless manner and implanted hiPS-Cart into 3.5 mm large defects created in the femurs of immunodeficient mice to examine the repair capacity. [Tissue Engineering Part A] |
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| The authors summarize COVID-19 pathogenesis, respective areas where cell therapies have potential, and the ongoing 89 cell therapy trials in COVID-19 as of January 1, 2021. [Science Advances] |
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| Scientists summarize the current understanding on roles of mitochondrial dynamics during stem cell homeostasis and aging, and lineage-specific differentiation. [Cell Death & Disease] |
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| Orizuru Therapeutics, Inc., a research and development-driven company focusing on the development of iPSC-based regenerative medicine and the application of iPSC technology, has announced the launch of its operations. [Orizuru Therapeutics, Inc.] |
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| October 14, 2021 Wädenswil, Switzerland |
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| Michigan State University – East Lansing, Michigan, United States |
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| Danaher – Toronto, Ontario, Canada |
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| The Scripps Research Institute – La Jolla, California, United States |
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| Philipps University of Marburg – Marburg, Germany |
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| UCLA Jules Stein Eye Institute – Los Angeles, California, United States |
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