 | | Vol. 16.34 – 1 September, 2021 |
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| After wrapping iPSC protein, the nanovaccine iPSC@RBC-Mlipo exhibited obvious splenic accumulation, systemic specific antitumor immunity evocation, and effective tumor expansion and metastasis inhibition in mice.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers generated cortical organoids from skin fibroblasts of patients with 16p11.2 copy number varient to investigate impacted neurodevelopmental processes and showed that organoid size recapitulated macrocephaly and microcephaly phenotypes observed in the patients with 16p11.2 deletions and duplications.
[Molecular Psychiatry] |
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| The authors examined a dataset comprising around 2 million nuclei spanning E9.5–E13.5 of mouse embryonic development to quantify transcriptome-wide changes in alternative polyadenylation.
[Nature Communications] |
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| Scientists reported a method to generate developmentally relevant human heart organoids by self-assembly using human PSCs. Heart organoids were comparable to age-matched human fetal cardiac tissues at the transcriptomic, structural, and cellular level.
[Nature Communications] |
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| Investigators identified CARdiomyocyte Maturation-Associated lncRNA (CARMA), a conserved long non-coding RNA controlling cardiomyocyte differentiation and maturation in human ESCs.
[Cardiovascular Research] |
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| The exact role of SOX10 in human neural crest development and the underlying molecular mechanisms of SOX10-related human diseases remain poorly understood due to the lack of appropriate human model systems. Researchers successfully generated SOX10-knockout human iPSCs by the CRISPR-Cas9 gene editing tool.
[Cell Death & Disease] |
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| The authors used a well-controlled human iPSC pancreatic differentiation model to elucidate the molecular mechanisms underlying HNF1B-associated diabetes.
[Stem Cell Reports] |
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| Scientists established a robust growth-factor-free protocol for generating definitive endoderm and pancreatic progenitors cells, facilitating scalable production of pancreatic cells for regenerative applications.
[Stem Cell Reports] |
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| Researchers described a unique, miniaturized 96-Transwell microplate system where human pluripotent stem cells-derived alveolar-like cells were cultured at an air–liquid interface.
[Scientific Reports] |
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| Investigators used iPSCs from a patient carrying a p.A152T tau variant to create a robust, functional cellular assay system for probing pathophysiological tau accumulation and phosphorylation.
[Scientific Reports] |
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 | | | The authors discuss patient-specific in vitro models of genetic diseases of the heart based on iPSCs, that address questions surrounding how different variants in the SCN5A gene produce different clinical syndromes.
[Biochemical Pharmacology] |
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| The governing Board of the California Institute for Regenerative Medicine has approved a trio of awards, totaling approximately $4 million, to University of California San Diego School of Medicine researchers to advance studies of new stem cell-based treatments for multiple types of cancer and amyotrophic lateral sclerosis.
[UC San Diego Health] |
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| October 19, 2021
London, England, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Stanford University – La Jolla, California, United States |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | Danaher – Toronto, Ontario, Canada |
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| | The Scripps Research Institute – La Jolla, California, United States |
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