| Vol. 16.42 – 27 October, 2021 |
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| Scientists presented a chip-based culture system that enabled the self-organization of micropatterned stem cells into precise 3D cell-fate patterns and organ shapes and recreated neural tube folding from human stem cells in a dish. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the development of a cerebral organoid slice model derived from human iPSCs that recapitulated mature cortical architecture and displayed early molecular pathology of C9ORF72 ALS/FTD. [Nature Neuroscience] |
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| Using a computational framework based on Gaussian processes and fractional Brownian motion, the authors showed that average chromatin diffusion properties were surprisingly similar in interphase and mitosis in mouse ESCs. [Nature Communications] |
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| Investigators generated CHD8 knockout human ESCs by CRISPR/Cas9 technology and characterized the effect of loss-of-function of CHD8 on pluripotency maintenance and lineage determination by utilizing efficient directed differentiation protocols. [Cell Death & Disease] |
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| Researchers generated micropatterned colonies of iPSCs to test whether non-synonymous single nucleotide variants (nsSNVs) influenced patterning of radially ordered germ layers. [Stem Cell Reports] |
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| The authors investigated how human iPSCs (hiPSCs) overcame hyperosmotic stress compared to a cell line that did not harbor pluripotent characteristics and found possible implications of microtubule organization on the response to hyperosmotic stress in hiPSCs. [Stem Cell International] |
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| Scientists differentiated human amniotic fluid-derived iPSCs into a mixed population of neurons. Functional assessments were performed by evaluating electrophysiological properties and the effect of a panel of neuropharmacological agents on spontaneous activity. [Stem Cell Reviews and Reports] |
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| Investigators generated iPSCs from patients with familial schizophrenia, differentiated these cells into neurons, and investigated the molecular and cellular phenotypes of the patient’s neurons. [Translational Psychiatry] |
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| Scientists investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with amyotrophic lateral sclerosis (ALS) carrying hexanucleotide expansions in C9ORF72. [iScience] |
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| Researchers described functions of plant-derived fibroblast growth factor 2 and human serum albumin in maintenance and differentiation of human iPSCs. [Cell Biology International] |
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| The authors discuss the role of retinoic acid (RA) in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification. [Stem Cell Reports] |
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| The International Space Station (ISS) National Laboratory has unveiled a research announcement seeking proposals to demonstrate biomanufacturing activities in microgravity. [The International Space Station] |
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| November 10 – 19, 2021 Virtual |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| Herophilus – San Francisco, California, United States |
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| Northwestern University – Chicago, Illinois, United States |
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| Buck Institute for Research on Aging – Novato, California, United States |
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