ESC & iPSC News Volume 16.42 | Oct 27 2021

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    2021-10-27 | ESC 16.42


    ESC & iPSC News by STEMCELL Technologies
    Vol. 16.42 – 27 October, 2021
    TOP STORY

    Human Neural Tube Morphogenesis In Vitro by Geometric Constraints

    Scientists presented a chip-based culture system that enabled the self-organization of micropatterned stem cells into precise 3D cell-fate patterns and organ shapes and recreated neural tube folding from human stem cells in a dish.
    [Nature]

    Abstract

    Facts Vs. claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Human ALS/FTD Brain Organoid Slice Cultures Display Distinct Early Astrocyte and Targetable Neuronal Pathology

    Researchers reported the development of a cerebral organoid slice model derived from human iPSCs that recapitulated mature cortical architecture and displayed early molecular pathology of C9ORF72 ALS/FTD.
    [Nature Neuroscience]

    Full Article

    Precise Measurements of Chromatin Diffusion Dynamics by Modeling Using Gaussian Processes

    Using a computational framework based on Gaussian processes and fractional Brownian motion, the authors showed that average chromatin diffusion properties were surprisingly similar in interphase and mitosis in mouse ESCs.
    [Nature Communications]

    Full Article

    CHD8 Safeguards Early Neuroectoderm Differentiation in Human ESCs and Protects from Apoptosis during Neurogenesis

    Investigators generated CHD8 knockout human ESCs by CRISPR/Cas9 technology and characterized the effect of loss-of-function of CHD8 on pluripotency maintenance and lineage determination by utilizing efficient directed differentiation protocols.
    [Cell Death & Disease]

    Full Article

    Plating Human iPSC Lines on Micropatterned Substrates Reveals Role for ITGB1 nsSNV in Endoderm Formation

    Researchers generated micropatterned colonies of iPSCs to test whether non-synonymous single nucleotide variants (nsSNVs) influenced patterning of radially ordered germ layers.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Hyperosmotic Stress Induces a Specific Pattern for Stress Granule Formation in Human-Induced Pluripotent Stem Cells

    The authors investigated how human iPSCs (hiPSCs) overcame hyperosmotic stress compared to a cell line that did not harbor pluripotent characteristics and found possible implications of microtubule organization on the response to hyperosmotic stress in hiPSCs.
    [Stem Cell International]

    Full Article

    Electrophysiological- and Neuropharmacological-Based Benchmarking of Human Induced Pluripotent Stem Cell-Derived and Primary Rodent Neurons

    Scientists differentiated human amniotic fluid-derived iPSCs into a mixed population of neurons. Functional assessments were performed by evaluating electrophysiological properties and the effect of a panel of neuropharmacological agents on spontaneous activity.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Multiple Alterations in Glutamatergic Transmission and Dopamine D2 Receptor Splicing in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Familial Schizophrenia

    Investigators generated iPSCs from patients with familial schizophrenia, differentiated these cells into neurons, and investigated the molecular and cellular phenotypes of the patient’s neurons.
    [Translational Psychiatry]

    Full Article

    An Integrated Multi-Omic Analysis of iPSC-Derived Motor Neurons from C9ORF72 ALS Patients

    Scientists investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with amyotrophic lateral sclerosis (ALS) carrying hexanucleotide expansions in C9ORF72.
    [iScience]

    Full ArticleGraphical Abstract

    Plant-Derived Human Recombinant Growth Factors and Serum Albumin Maintain Stemness of Human Induced Pluripotent Stem Cells

    Researchers described functions of plant-derived fibroblast growth factor 2 and human serum albumin in maintenance and differentiation of human iPSCs.
    [Cell Biology International]

    Abstract

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Retinoic Acid Signaling in Heart Development: Application in the Differentiation of Cardiovascular Lineages from Human Pluripotent Stem Cells

    The authors discuss the role of retinoic acid (RA) in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification.
    [Stem Cell Reports]

    Full Article

    INDUSTRY AND POLICY NEWS

    ISS National Lab Releases Research Announcement Focused on In-Space Production Applications in Biomanufacturing

    The International Space Station (ISS) National Laboratory has unveiled a research announcement seeking proposals to demonstrate biomanufacturing activities in microgravity.
    [The International Space Station]

    Press Release

    FEATURED EVENT

    American College of Toxicology Annual Meeting

    November 10 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Gene Editing

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Production Manager – Stem Cell and Organoid

    Herophilus – San Francisco, California, United States

    Principal Investigator – Organoid Biology

    VIB – Organoid Biology

    Postdoctoral Research Fellow – iPSC Reprogramming

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Researcher – Neurodegenerative Disease Modeling

    Buck Institute for Research on Aging – Novato, California, United States

    > See All Jobs

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