 | | Vol. 16.45 – 17 November, 2021 |
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| Researchers characterized, in a spatially resolved manner, the single-cell transcriptional profile of an entire gastrulating human embryo, staged to be between 16 and 19 days after fertilization.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists utilized patient-derived iPSCs to generate 3D cerebral organoids to model neuropathology of schizophrenia during its early-arising neurodevelopmental period.
[Molecular Psychiatry] |
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| The authors generated functional human PSC-derived cholangiocytes that displayed many characteristics of mature bile duct cells including high levels of cystic fibrosis transmembrane conductance regulator and the presence of primary cilia capable of sensing flow.
[Nature Communications] |
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| Generation of kidney organoids from Tuberous Sclerosis Complex patient-derived-human iPSCs allowed investigators to recapitulate a rare kidney tumor called angiomyolipoma.
[Nature Communications] |
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| Researchers provided a detailed protocol describing how to form heart-forming organoids within 14 days, that could be used on many different human PSC lines and be combined with manipulation technologies such as gene targeting and drug testing.
[Nature Protocols] |
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| The authors developed a murine model to investigate the in vivo properties of human iPSC-red blood cells (RBCs). iPSC lines were produced from human peripheral blood mononuclear cells by transient expression of plasmids containing OCT4, SOX2, MYC, KLF4 and BCL-XL genes.
[American Journal of Hematology] |
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| Investigators employed ATAC-seq and Hi-C techniques to explore the chromatin accessibility and 3D genome organization of nuclear transfer ESCs (ntESCs) and showed that the chromatin accessibility and genome structures of somatic cells were re-arranged to ESC-like states overall in ntESCs.
[Cell Death & Disease] |
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| Regorafenib preferentially increased the growth inhibition and apoptosis of CK19+ cells in vitro, whereas sorafenib, apatinib, and 5-fluorouracil did not.
[Cell Death & Disease] |
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| To evaluate mitophagy during iPSC differentiation, researchers performed live-cell imaging of mitochondria and lysosomes in human iPSCs differentiating into vascular endothelial cells using confocal microscopy.
[Journal of Biological Chemistry] |
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| Scientists analyzed stage-specific RNA-, ChIP-, and ATAC-sequencing data to dissect transcriptional and regulatory mechanisms during pancreatic development.
[Communications Biology] |
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| The authors employed quantitative proteomic profiling to identify proteins whose expression was regulated by the ERK5 pathway in mouse ESCs, revealing a function for ERK5 signaling in regulating dynamically expressed early embryonic 2-cell stage genes.
[Biochemical Journal] |
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| Investigators demonstrated proof-of-concept for piggyBac prime-editing in a newly designed lentiviral traffic light reporter, which allowed for estimation of gene correction and defective editing resulting in indels, based on expression of two different fluorophores.
[Scientific Reports] |
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| Differentiation platforms were established to model neural induction from stem cells, and scientists characterized these differentiated cell types by 10x single cell RNA sequencing.
[Scientific Reports] |
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| The authors highlight an important regulatory role for DPPA2 and DPPA4 at the transitional boundary between pluripotency and differentiation, and discuss their functions in the context of cancer cells.
[Stem Cell Reports] |
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| Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, announced that the US FDA has granted Fast Track designation to pridopidine for development as a potential treatment for Huntington’s Disease.
[Prilenia Therapeutics B.V.] |
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| February 2 – 6, 2022
Salt Lake City, Utah, United States |
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| | UC San Diego Health – La Jolla, California, United States |
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| NUI Galway – Galway, Ireland |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | KU Leuven – Leuven, Brussels |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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