 | | Vol. 16.46 – 24 November, 2021 |
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| Researchers introduced a method that simultaneously measured protein expression and thermal stability changes in cells and provided the web-based visualization tool ProteoTracker, and applied their method to study differences between human PSCs and several cell types.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a human stem cell model of pancreas differentiation, investigators discovered that only a subset of pancreatic enhancers was FOXA-primed, whereas the majority was unprimed and engaged FOXA upon lineage induction.
[Nature Communications] |
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| To test whether diploidization resulted from aberrant DNA replication, the authors profiled DNA replication timing in isogenic haploid and diploid ESCs.
[Genome Research] |
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| Scientists identified mitogen-activated protein kinase kinase 6 as a chromatin relaxer and found that it could significantly enhance reprogramming.
[Cell Death & Differentiation] |
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| Researchers reported the development of a chemically defined, artificial 3D microniche for iPSCs’ growth and reliable expansion, constructed with degradable polyethyleneglycol-co-polycaprolactone and RGDfk-functionalized dendritic polyglycerol precursors.
[Biomaterials] |
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| Investigators described the development and the scaled manufacturing of an allogeneic human PSC-derived articular chondrocyte formulation that exhibited long-term functional repair of porcine articular cartilage.
[NPJ Regenerative Medicine] |
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| The authors showed that O-GlcNAcylation of Sox2 at threonine 258 (T258) regulated mouse ESC self-renewal and early cell fate. ESCs in which wild-type Sox2 was replaced with the Sox2 T258A mutant exhibited reduced self-renewal, whereas ESCs with the Sox2 S248A point mutation did not.
[Experimental and Molecular Medicine] |
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| The role of Nox4 was examined using iPSCs generated from Nox4 knockout mice. Differentiation markers showed significantly reduced expression levels consistent with the importance of Nox4-generated reactive oxygen species during this process.
[Stem Cell Reviews and Reports] |
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| Researchers demonstrated the generation of advanced in vitro multiocular organoids from human iPSCs. In the 2D culture, self-formed multizone ocular progenitor cells spanned the neuroectoderm, surface ectoderm, neural crest, and retinal pigment epithelium, mimicking early stages of eye development.
[Stem Cell Research & Therapy] |
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| Scientists genetically modified human iPSCs with a zinc finger nuclease technology to introduce a cDNA encoding an anti-EpCAM chimeric antigen receptor into the adeno-associated virus integration site 1, a “safe harbor” for transgene insertion into human genome.
[Stem Cell Research & Therapy] |
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| The authors summarize the effects of nanomaterials on the proliferation and differentiation of ESCs, mesenchymal stem cells and neural stem cells.
[Chemosphere] |
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| Investigators review the state-of-the-art knowledge of compartmentalization in the cell nucleus and the relevance of this process for transcriptional regulation, particularly in PSCs.
[Biochemical Society Transactions] |
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| Cytovia Therapeutics, Inc. and Cellectis announced that they have expanded their collaboration of TALEN® gene-edited iPSC-derived natural killer (iNK) and chimeric antigen receptor (CAR)-NK cells to include new CAR target and development in China by Cytovia’s joint venture entity, CytoLynx Therapeutics.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)] |
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| Dr. Lin Ma is the recipient of STEM CELLS’s Young Investigator Award for 2021. Her work on engineering hypoimmunogenic human PSCs exemplifies the potential of the field and promise of this young next generation of researchers.
[ALPHAMED PRESS (EurekAlert!)] |
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| January 30 – February 2, 2022
Keystone, Colorado, United States |
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| | Stanford University – Palo Alto, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | KU Leuven – Leuven, Brussels |
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