ESC & iPSC News Volume 16.47 | Dec 1 2021

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    2021-12-01 | ESC 16.47


    ESC & iPSC News by STEMCELL Technologies
    Vol. 16.47 – 1 December, 2021
    TOP STORY

    Functional Human Gastrointestinal Organoids Can Be Engineered from Three Primary Germ Layers Derived Separately from Pluripotent Stem Cells

    Researchers developed an organoid assembly approach starting with cells from the three primary germ layers — enteric neuroglial, mesenchymal, and epithelial precursors — that were derived separately from human PSCs.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Explore scientific events this December with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Generation and Characterization of Stable Pig Pregastrulation Epiblast Stem Cell Lines

    Guided by insights from a large-scale single-cell transcriptome analysis of pig embryos from embryonic day (E) 0 to E14, the authors developed an in vitro culture medium for establishing and maintaining stable PSC lines from pig E10 pregastrulation epiblasts.
    [Cell Research]

    Full Article

    Evolutionary Epigenomic Analysis in Mammalian Early Embryos Reveal Species-Specific Innovations and Conserved Principles of Imprinting

    Through analysis of oocytes and early embryos in human, bovine, porcine, rat, and mouse, investigators revealed remarkable species-specific innovations as no single animal model fully recapitulated the human epigenetic transition.
    [Science Advances]

    Full Article

    The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem Cells

    Scientists showed that the human genome’s replication program was broadly encoded in DNA and identified 1,617 cis-acting replication timing quantitative trait loci – sequence determinants of replication initiation.
    [Nature Communications]

    Full Article

    Loss of PRC2 Subunits Primes Lineage Choice during Exit of Pluripotency

    Researchers explored the roles of two distinct Polycomb Repressive Complex 2 (PRC2) complexes in lineage specification and commitment, using single-cell transcriptomics and mouse embryoid bodies derived from Mtf2 and Jarid2 null ESCs.
    [Nature Communications]

    Full Article

    Generation of Developmentally Competent Oocytes and Fertile Mice from Parthenogenetic Embryonic Stem Cells

    Investigators showed that an unlimited number of oocytes could be derived from parthenogenetic ESCs and produce healthy offspring.
    [Protein & Cell]

    Full Article

    Kinematic Self-Replication in Reconfigurable Organisms

    The authors found that synthetic multicellular assemblies could replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full ArticlePress Release

    Lysophosphatidic Acid Shifts Metabolic and Transcriptional Landscapes to Induce a Distinct Cellular State in Human Pluripotent Stem Cells

    Scientists reported that the metabolic landscape of human PSCs was shifted by signaling lipid lysophosphatidic acid (LPA), which naturally exists. LPA led to a distinctive transcriptome profile that was not associated with de novo lipogenesis.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Nicotinamide Promotes Cardiomyocyte Derivation and Survival through Kinase Inhibition in Human Pluripotent Stem Cells

    Researchers showed that nicotinamide played multiplex roles in mesoderm differentiation of human ESCs. Nicotinamide promoted cardiomyocyte fate from mesoderm progenitor cells, and suppressed the emergence of other cell types.
    [Cell Death & Disease]

    Full Article

    Transplantation of Human Embryonic Stem Cells Alleviates Motor Dysfunction in AAV2-Htt171-82Q Transfected Rat Model of Huntington’s Disease

    The authors observed if transplantation of superparamagnetic iron oxide nanoparticle-labeled human ESCs could migrate in the neural degenerated area and improve motor dysfunction in an AAV2-Htt171-82Q transfected Huntington rat model.
    [Stem Cell Research & Therapy]

    Full Article

    MiRNA-Mediated Control of Exogenous OCT4 during Mesenchymal-Epithelial Transition Increases Measles Vector Reprogramming Efficiency

    Using measles reprogramming vectors, scientists presented microRNA-targeting of exogenous OCT4 to shut down its expression during the mesenchymal to the epithelial transition phase of reprogramming.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    High Expression of Uracil DNA Glycosylase Determines C to T Substitution in Human Pluripotent Stem Cells

    Investigators found that the editing efficiency of cytosine base editor was significantly lower than that of adenine base editor in human ESCs, which were associated with high expression of DNA glycosylases, the key component of the base excision repair pathway.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    β-Catenin Links Cell Seeding Density to Global Gene Expression during Mouse Embryonic Stem Cell Differentiation

    Researchers revealed that the expression of thousands of genes in mouse ESCs was affected by cell seeding density and that low cell density enhanced the efficiency of differentiation.
    [iScience]

    AbstractFull ArticleGraphical Abstract

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    REVIEWS

    Current Progress of Rehabilitative Strategies in Stem Cell Therapy for Spinal Cord Injury: A Review

    Scientists summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of spinal cord injury.
    [NPJ Regenerative Medicine]

    Full Article

    Recent Strategies for Enhancing the Therapeutic Efficacy of Stem Cells in Wound Healing

    The authors outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation.
    [Stem Cell Research & Therapy]

    Full Article

    Production of Functional Cardiomyocytes and Cardiac Tissue from Human Induced Pluripotent Stem Cells for Regenerative Therapy

    Investigators outline how to overcome hurdles in the production of functional cardiomyocytes from human iPSCs (hiPSCs-CMs) to realize the transplantation of hiPSC-CMs in patients with heart failure and introduce cutting-edge findings and perspectives for future regenerative therapy.
    [Journal of Molecular and Cellular Cardiology]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    AgeX Therapeutics’ Licensee ImStem Biotechnology Announces First US Multiple Sclerosis Patient Dosed with IMS001

    AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc., a biopharmaceutical company developing human ESC-derived mesenchymal stem cells, has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.
    [AgeX Therapeutics, Inc.]

    Press Release

    $5.5 Million CIRM Grant to Fund Development of New Cervical Spinal Cord Injury Therapeutic

    Aileen Anderson, director of the University of California Irvinc’s Sue & Bill Gross Stem Cell Research Center and professor of physical medicine & rehabilitation, has been awarded a 30-month, $5.5 million grant from the California Institute for Regenerative Medicine (CIRM).
    [UCI News]

    Press Release

    FEATURED EVENT

    12th AACR-JCA Conference: Breakthroughs in Cancer Research

    February 5 – 9, 2022
    Maui, Hawaii, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Developmental Biology

    NIH National Institute of Environmental Health Sciences – Research Triangle Park, NC, United States

    Postdoctoral Research Associate – Neurodegenerative Diseases

    University of Virginia – Charlottesville, Virginia, United States

    Faculty Positions – Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine

    Stanford University – Palo Alto, California, United States

    Research Scientists – Stem Cells and Organoids

    RIKEN – Hirosawam, Japan

    Automation Scientist – Modeling Pediatric Diseases

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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