| Vol. 16.47 – 1 December, 2021 |
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| Researchers developed an organoid assembly approach starting with cells from the three primary germ layers — enteric neuroglial, mesenchymal, and epithelial precursors — that were derived separately from human PSCs. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Guided by insights from a large-scale single-cell transcriptome analysis of pig embryos from embryonic day (E) 0 to E14, the authors developed an in vitro culture medium for establishing and maintaining stable PSC lines from pig E10 pregastrulation epiblasts. [Cell Research] |
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| Through analysis of oocytes and early embryos in human, bovine, porcine, rat, and mouse, investigators revealed remarkable species-specific innovations as no single animal model fully recapitulated the human epigenetic transition. [Science Advances] |
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| Scientists showed that the human genome’s replication program was broadly encoded in DNA and identified 1,617 cis-acting replication timing quantitative trait loci – sequence determinants of replication initiation. [Nature Communications] |
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| Researchers explored the roles of two distinct Polycomb Repressive Complex 2 (PRC2) complexes in lineage specification and commitment, using single-cell transcriptomics and mouse embryoid bodies derived from Mtf2 and Jarid2 null ESCs. [Nature Communications] |
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| Investigators showed that an unlimited number of oocytes could be derived from parthenogenetic ESCs and produce healthy offspring. [Protein & Cell] |
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| The authors found that synthetic multicellular assemblies could replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists reported that the metabolic landscape of human PSCs was shifted by signaling lipid lysophosphatidic acid (LPA), which naturally exists. LPA led to a distinctive transcriptome profile that was not associated with de novo lipogenesis. [Cell Reports] |
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| Researchers showed that nicotinamide played multiplex roles in mesoderm differentiation of human ESCs. Nicotinamide promoted cardiomyocyte fate from mesoderm progenitor cells, and suppressed the emergence of other cell types. [Cell Death & Disease] |
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| The authors observed if transplantation of superparamagnetic iron oxide nanoparticle-labeled human ESCs could migrate in the neural degenerated area and improve motor dysfunction in an AAV2-Htt171-82Q transfected Huntington rat model. [Stem Cell Research & Therapy] |
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| Using measles reprogramming vectors, scientists presented microRNA-targeting of exogenous OCT4 to shut down its expression during the mesenchymal to the epithelial transition phase of reprogramming. [Molecular Therapy-Methods & Clinical Development] |
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| Investigators found that the editing efficiency of cytosine base editor was significantly lower than that of adenine base editor in human ESCs, which were associated with high expression of DNA glycosylases, the key component of the base excision repair pathway. [Molecular Therapy-Methods & Clinical Development] |
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| Researchers revealed that the expression of thousands of genes in mouse ESCs was affected by cell seeding density and that low cell density enhanced the efficiency of differentiation. [iScience] |
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| Scientists summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of spinal cord injury. [NPJ Regenerative Medicine] |
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| The authors outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation. [Stem Cell Research & Therapy] |
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| Investigators outline how to overcome hurdles in the production of functional cardiomyocytes from human iPSCs (hiPSCs-CMs) to realize the transplantation of hiPSC-CMs in patients with heart failure and introduce cutting-edge findings and perspectives for future regenerative therapy. [Journal of Molecular and Cellular Cardiology] |
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| AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc., a biopharmaceutical company developing human ESC-derived mesenchymal stem cells, has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001. [AgeX Therapeutics, Inc.] |
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| Aileen Anderson, director of the University of California Irvinc’s Sue & Bill Gross Stem Cell Research Center and professor of physical medicine & rehabilitation, has been awarded a 30-month, $5.5 million grant from the California Institute for Regenerative Medicine (CIRM). [UCI News] |
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| February 5 – 9, 2022 Maui, Hawaii, United States |
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| NIH National Institute of Environmental Health Sciences – Research Triangle Park, NC, United States |
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| University of Virginia – Charlottesville, Virginia, United States |
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| Stanford University – Palo Alto, California, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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