 | | Vol. 16.48 – 8 December, 2021 |
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| Researchers showed that linker histone H1 was post-translationally modulated by SUMO2/3, which facilitated its fixation onto ultra-condensed heterochromatin in ESCs.
[Molecular Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that SPEN played an important role in the initiation of X chromosome inactivation. Spen null female mouse ESCs were defective in Xist upregulation upon differentiation.
[Nature Communications] |
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| Investigators showed that in pre-implantation embryos and naïve ESCs, hypomethylated promoters of germline genes bound by the PRC1.6 DNA-binding subunits MGA/MAX/E2F6 were enriched for RING1B-dependent H2AK119ub1 and H3K9me3.
[Nature Communications] |
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| Scientists addressed the role of matrix mellanoproteinases (MMPs) in stem cell differentiation by assaying MMP expression and activity during differentiation of mouse ESCs on mouse embryonic fibroblast derived matrices of varying stiffness and composition.
[Biomaterials] |
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| Researchers characterized stage-specific methylation dynamics and the function of ten-eleven translocations (TETs) during human cardiomyocyte differentiation. Human ESCs in which all three TET genes were inactivated failed to generate cardiomyocytes, with altered mesoderm patterning and defective cardiac progenitor specification.
[Cell Reports] |
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| Investigators found a set of four defined factors that could reprogram fibroblasts into iPSCs, which were shown to be molecularly and functionally equivalent to blastocyst-derived ESCs, thus showing that defined factors could induce authentic reprogramming without the need of oocytes.
[Cold Spring Harbor Perspectives in Biology] |
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| Scientists established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.
[Stem Cell Reports] |
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| The authors showed that the combination of activin A, fibroblast growth factor and the Wnt inhibitor XAV939 supported establishment and continuous expansion of PSC lines from porcine, ovine and bovine embryos.
[Development] |
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| Researchers generated an iPSC line from the skin fibroblasts collected from a healthy 50-year old male donor. This model could be used to model physiological processes and screen drug validation in vitro.
[Stem Cell Research] |
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| Investigators demonstrated marker expression and matrix competency of cardiac fibroblasts developed through a developmentally conserved epicardial pathway as shown next to primary human cardiac fibroblasts.
[Journal of Molecular and Cellular Cardiology] |
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| Scientists integrated genome-wide datasets of RNA-chromatin and promoter-genome interactions in human ESCs to identify putative RNA-mediated promoter interactions.
[Scientific Reports] |
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| Investigators offer a phylogenetic and ontogenetic overview of the primitive streak and its role in mediating amniote gastrulation and discuss the implications of ESC–based models of early mammalian embryogenesis on the function of this iconic structure.
[Science] |
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| The authors highlight reproducible findings and emerging trends in recent schizophrenia-related iPSC studies and illuminate the relevance of the results in the context of human brain development.
[Trends in Neurosciences] |
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| Each year, the Ottawa Hospital honors three outstanding researchers for discoveries that are having an impact around the world. This year’s honorees have led game-changing discoveries and clinical trials in areas such as ovarian cancer, stem cells and blood transfusions.
[Ottawa Citizen] |
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| Dr. Sara Palma-Tortosa is the 2021 recipient of the STEM CELLS Translational Medicine (SCTM) Young Investigator Award. The award honors a young researcher who served as the principal author of an article published in SCTM that, over the course of a year, is deemed to have the most impact.
[Stem Cells Translational Medicine] |
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| January 23 – 26, 2022
Santa Fe, New Mexico, United States |
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| | Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States |
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| | KU Leuven – Leuven, Belgium |
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| | King’s College London – London, England, United Kingdom |
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| | NIH National Institute of Environmental Health Sciences – Research Triangle Park, North Carolina, United States |
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| | University of Virginia – Charlottesville, Virginia, United States |
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