 | | Vol. 17.00 – 5 January, 2022 |
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| A proteome map of COVID-19 skin was established and the susceptibility of human iPSC-derived skin organoids with hair follicles and nervous system to SARS-CoV-2 infection was investigated.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed a therapeutic regimen consisting of the combination of human PSC-derived corneal endothelial precursors with nicotinamide for effective treatment of corneal endothelial dysfunction.
[Journal of Clinical Investigation] |
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| To facilitate further genetic study of human-chimpanzee divergence, investigators generated human and chimpanzee autotetraploids and allotetraploids by fusing iPSCs of each species.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers generated human fallopian tube epithelial (FTE) organoids from BRCA1 mutation carriers that provided a faithful physiological in vitro model of FTE lesion generation and early carcinogenesis.
[Cell Reports] |
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| Scientists showed that NANOG mediated Otx2 downregulation in the absence of cytokines and that this was essential for primordial germ cell-like cells induction by NANOG.
[Stem Cell Reports] |
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| The authors generated a Beta2-microglobulin (B2M) homozygous knockout somatic cell nuclear transfer-induced ESC line using CRISPR/Cas9-mediated gene targeting.
[Stem Cell Research] |
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| Investigators discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs.
[Stem Cells International] |
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| Scientists identified a molecular mechanism in iPSCs responding to intermittent compressive force by analyzing the global gene expression profile.
[International Journal of Oral Science] |
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| Researchers generated Sephs1 knockout ESCs and found that deficiency of SEPSH1 had little effect on pluripotency maintenance and proliferation.
[Biochemical and Biophysical Research Communications] |
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| Directed neuronal differentiation of human PSCs, neural progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly reproducible differentiation of mature and functional neurons.
[Stem Cell Reports] |
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| The authors describe the current state of human PSCs (hPSCs) towards recapitulating human myogenesis ex vivo, considerations of stem cell and progenitor cell state as well as function for future use of hPSC-derived muscle cells in regenerative medicine.
[Experimental Cell Research] |
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| Scientists review recent advances of in vitro and in vivo studies on histone modifications in neural differentiation.
[Heliyon] |
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| Dr. Steven DeVries, a professor of Ophthalmology at the University of Wisconsin, has received an International Research Collaborators Award from Research to Prevent Blindness that will allow him to learn from scientists at Ritsumeikan University about the process of growing 3D retinal organoids from stem cells.
[Ophthalmology Times] |
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| January 23 – 26, 2022
Santa Fe, New Mexico, United States |
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| | Center for Genomic Regulation – Barcelona, Spain |
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| | Wisconsin National Primate Research Center – Madison, Wisconsin, United States |
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| University of Luxembourg – Luxembourg, Luxembourg |
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| | Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States |
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| | KU Leuven – Leuven, Belgium |
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