 | | Vol. 17.01 – 12 January, 2022 |
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| By designing RNA-only circuits with miRNA-ON and -OFF switch mRNAs that encoded a lethal ribonuclease, Barnase, and its inhibitor, Barstar, the authors efficiently purified specific cell types, including human iPSCs and differentiated cardiomyocytes, without flow cytometry.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that G-quadruplexes (G4s) were key genomic structural features linked to cellular differentiation and found that G4s were highly abundant in human ESCs and were lost during lineage specification.
[Nature Communications] |
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| Researchers investigated the potential of bacteriophage-chimeric retrovirus-like particles for the non-integrative delivery of RNA molecules in human iPSCs for CRISPR/Cas9 applications.
[BMC Biology] |
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| Scientists developed a “disease in a dish” model for oculocutaneous albinism (OCA) 1A and OCA2 types using iPSCs to generate retinal pigment epithelium.
[Stem Cell Reports] |
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| The authors found that, despite the enrichment of histone 3 lysine 79 methylation on thousands of actively transcribed genes in somatic cells, disruptor of telomeric silencing 1-like (DOT1L) inhibition did not immediately cause the shutdown of the somatic transcriptional profile to enable transition to pluripotency.
[Stem Cell Reports] |
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| Researchers described an optimized stepwise protocol to introduce disease-specific mutations of long QT syndrome into human PSCs.
[Stem Cell Reviews and Reports] |
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| Scientists generated Rothmund-Thomson syndrome (RTS) patient-derived iPSCs to dissect the pathological signaling leading to RTS patient-associated osteosarcoma.
[PLoS Genetics] |
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| The authors directly compared the mutation burden of cultured iPSCs with their isogenic embryonic cells during human embryogenesis.
[iScience] |
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| By applying an in vitro system enabling inducible gene expression control, investigators reported that moderate induction of transcriptionally active exogenous β-catenin in β-catenin null mouse ESCs promoted epiblast-like cell derivation in vitro.
[iScience] |
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| Building on observations that mutations in the JIP3 gene result in lysosome-filled axonal swellings, researchers analyzed the impact of JIP3 depletion on the cytoskeleton of human neurons.
[Communications Biology] |
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| The authors evaluate the status of modeling neurodegenerative diseases using iPSCs, including methods for deriving and using disease-relevant neuronal and glial lineages.
[Cell Stem Cell] |
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| Century Therapeutics and Bristol Myers Squibb announced a research collaboration and license agreement to develop and commercialize up to four iPSC derived, engineered natural killer cell and/or T cell programs for hematologic malignancies and solid tumors.
[Century Therapeutics] |
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| Fate Therapeutics, Inc. announced that the US FDA has cleared the company’s Investigational New Drug application for FT536, an off-the-shelf, multiplexed-engineered, iPSC-derived, chimeric antigen receptor natural killer cell product candidate.
[Fate Therapeutics, Inc.] |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | Wisconsin National Primate Research Center – Madison, Wisconsin, United States |
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| | Center for Genomic Regulation – Barcelona, Spain |
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| | Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States |
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