 | | Vol. 17.02 – 19 January, 2022 |
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| Scientists integrated human genetics with transcriptomic data from differentiation of human ESCs into cortical excitatory neurons.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers studied maturity-onset diabetes of the young 1 using human iPSC-derived pancreatic β-like patient and isogenic control cell lines in two different 3D contexts.
[Diabetes] |
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| The authors employed multiple functional analyses to characterize the role of Zinc Finger Protein 207 (ZFP207) in mouse ESCs.
[EMBO Reports] |
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| Scientists reported a novel stepwise strategy for directing the simultaneous induction of both mesoderm-derived cardiac and endoderm-derived lung epithelial lineages within a single differentiation of human iPSCs via temporal specific tuning of WNT and nodal signaling in the absence of exogenous growth factors.
[eLife] |
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| Investigators showed that NANOG mediated Otx2 downregulation in the absence of cytokines and that this was essential for primordial germ cell-like cells induction by NANOG.
[Stem Cell Reports] |
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| Researchers studied human iPSCs that had been expanded into a self-formed ectodermal autonomous multi-zone of cells that partially mimicked human eye development.
[Stem Cell Reports] |
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| Scientists proposed a reporter assay that utilized human iPSCs to detect changes in fibroblast growth factor signaling, which was essential for limb morphogenesis.
[iScience] |
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| Investigators presented a human iPSC-derived airway epithelial platform, composed of the major airway epithelial cell types, that was permissive to SARS-CoV-2 infection.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| The authors investigated Parkinson’s disease (PD)’s mechanism using dopaminergic neurons differentiated from human iPSCs carrying the ILE368ASN mutation within the PINK1 gene, which is strongly associated with PD.
[Communications Biology] |
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| To study the mechanisms in ESC self-renewal, screening and identification of key genes maintaining ESC self-renewal were performed by a genome-wide CRISPR-Cas9 knockout virus library.
[Stem Cells and Development] |
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| Investigators developed a reporter assay using human iPSCs to detect changes in the fibroblast growth factor signaling pathway, a pathway essential for limb morphogenesis.
[Journal of Bioscience and Bioengineering] |
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| The authors discuss insights into telomere protection in ESCs versus somatic cells and summarize findings on telomerase regulation as a function of pluripotency.
[Trends in Cell Biology] |
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| Keio University in Tokyo said it has started the world’s first clinical test using iPSCs to treat patients with spinal cord injuries.
[Kyodo News] |
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| | Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
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| | UK Research and Innovation – Oxfordshire, England, United Kingdom |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | Center for Genomic Regulation – Barcelona, Spain |
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