SCIENCE NEWS Scientists Discover New Method for Regenerating Heart Muscle by Direct Reprogramming Scientists directly reprogrammed fibroblasts in the heart to become cardiomyocytes. In doing so, they also found the first evidence that unrelated adult cells can be reprogrammed from one cell type to another without having to go all the way back to a stem cell state. [Press release from the Gladstone Institute of Cardiovascular Disease discussing online prepublication in Cell] Death Dance Reveals Secrets of Apoptosis in Dissociated Human Embryonic Stem Cells Researchers have unraveled the mystery of why human embryonic stem cells and induced pluripotent stem cells undergo programmed cell death when cultured in isolation. [Press release from the RIKEN Center for Developmental Biology discussing online prepublication in Cell Stem Cell] A Strategy to Fix a Broken Heart Engineers and physicians have built a scaffold that supports the growth and integration of stem cell-derived cardiac muscle cells. [Press release from the University of Washington discussing online prepublication in the Proceedings of the National Academy of Sciences USA] Human Embryonic Stem Cells Purified in New, Rapid Technique Researchers are reporting the first success in very rapidly purifying one type of embryonic stem cell from a mix of many different types of embryonic stem cells in the culture dish. The technique avoids the need to genetically alter the cells to distinguish them. [Press release from the University of California, San Francisco discussing online prepublication in Stem Cells and Development]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors Researchers report that a combination of three developmental transcription factors (Gata4, Mef2c, and Tbx5) rapidly and efficiently reprogrammed postnatal cardiac or dermal fibroblasts directly into differentiated cardiomyocyte-like cells. [Cell] Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells Genome-wide maps of nucleosomes with histone H3K4me3 and H3K27me3 modifications indicate that there is little difference between embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) with respect to these marks. Gene expression profiles confirm that the transcriptional programs of ESCs and iPSCs show very few consistent differences. [Cell Stem Cell] Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells Researchers show that the apoptosis of human embryonic stem cells, which is of a nonanoikis type, is caused by ROCK-dependent hyperactivation of actomyosin and efficiently suppressed by the myosin inhibitor Blebbistatin. [Cell Stem Cell] Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells Researchers show that actin-myosin contraction is a critical effector of the cell death response to human embryonic stem cell dissociation. [Cell Stem Cell] Lab-Specific Gene Expression Signatures in Pluripotent Stem Cells Data are consistent with the hypothesis that in vitro microenvironmental context differentially impacts the gene expression signatures of both induced-pluripotent stem cells and embryonic stem cells. [Cell Stem Cell] Proangiogenic Scaffolds as Functional Templates for Cardiac Tissue Engineering Researchers demonstrate a cardiac tissue-engineering strategy addressing multicellular organization, integration into host myocardium, and directional cues to reconstruct the functional architecture of heart muscle. [Proc Natl Acad Sci U S A] Generation of Genetically Modified Rats from Embryonic Stem Cells To monitor the pluripotency of rat embryonic stem cells, researchers generated Oct4-Venus transgenic rats via a conventional method, in which Venus is expressed by the Oct4 promoter/enhancer. [Proc Natl Acad Sci U S A] Proteomic Analysis of Sox2-Associated Proteins During Early Stages of Mouse Embryonic Stem Cell Differentiation Identifies Sox21 as a Novel Regulator of Stem Cell Fate Researchers provide new insights into the range of molecular processes through which Sox2 is likely to influence the fate of embryonic stem cells (ESCs), and provide further support for the conclusion that the expression of Sox proteins in ESCs must be precisely regulated. [Stem Cells] Vitamin C Promotes Widespread Yet Specific DNA Demethylation of the Epigenome in Human Embryonic Stem Cells Data identify a novel link between ascorbate-mediated signaling and specific epigenetic changes in human embryonic stem cells that might impact on pluripotency and reprogramming pathways. [Stem Cells] High Throughput Tracking of Pluripotent Human Embryonic Stem Cells with Dual FRET Molecular Beacons Studies demonstrate that fluorescence resonance energy transfer-based FACS using molecular beacons provides a useful tool for isolating Oct4-expressing pluripotent human embryonic stem cells (hESCs), and may also be adapted to selecting differentiating hESCs at specific developmental time points determined by transcription factor expression without functional or genomic alteration. [Stem Cells and Dev]
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POLICY NEWS Scientists Decry Proposed Ban on Chimp Research In the latest twist in the protracted debate over the use of chimpanzees in biomedical research, U.S. senators introduced the Great Ape Protection Act, an identical bill to one that has been stuck in a House of Representatives committee for more than a year. [Senate, United States] Senate Bill Would Encourage Drugs Targeting Rare Kids’ Diseases A group of bipartisan senators introduced legislation to entice drug makers to focus more intently on cures for uncommon children’s diseases. [Senate, United States] Decision Memo for Allogeneic Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome (CAG-00415N) The Centers for Medicare and Medicaid Services have determined that the evidence does not demonstrate that the use of allogeneic hematopoietic stem cell transplantation improves health outcomes in Medicare beneficiaries with myelodysplastic syndrome. [Centers for Medicare and Medicaid Services, United States] FDA Issues Assessments of the 510(k) Program and Use of Science in Decision-Making The U.S. Food and Drug Administration issued two comprehensive evaluations containing recommendations that address three key objectives of the agency’s public health mission as it relates to medical devices — foster device innovation, create a more predictable regulatory environment, and enhance device safety. [Food and Drug Administration, United States] Solicitation for Nominations: New Clinical Preventive Health for the United States Preventive Services Task Force [2010–19117] [Agency for Healthcare Research and Quality, United States] Technical Assistance Videocast for RFA-RR-10-007: Clinical and Translational Science Coordinating Center (U54) (NOT-RR-10-012) [National Institutes of Health, United States] NIH Common Fund Transformative Research Projects Program (R01) (RFA-RM-10-010) [National Institutes of Health, United States] Chimpanzee Biomedical Research Program Limited Competition (U42) (RFA-RR-10-008) [National Institutes of Health, United States] Proposed Collection; Comment Request; Assessing the Long-Term Impacts of the John E. Fogarty International Center’s Research and Training Programs (FR Doc. 2010-19160) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-19167) [National Institutes of Health, United States] 2010 Biological License Application Supplement Noteworthy Approvals [Center for Biologics Evaluation and Research, United States] Agency Information Collection Activities; Proposed Collection; Comment Request; Generic Food and Drug Administration Rapid Response Surveys [Docket No. FDA-2010-N-0380] [Food and Drug Administration, United States] Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Administrative Procedures for the Clinical Laboratory Improvement Amendments of 1988 Categorization [Docket No. FDA-2010-N-0199] [Food and Drug Administration, United States]
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EVENTS Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences 2nd Annual World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine September 11-17, 2010 Hydra, Greece Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia 5th Annual Meeting of the German Society for Stem Cell Research September 30-October 2, 2010 Lübeck, Germany 5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010 October 5-7, 2010 Hannover, Germany Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine October 7, 2010 Hertfordshire, United KingdomFraunhofer Life Science Symposium Leipzig 2010 October 29-30, 2010 Leipzig, Germany Select Biosciences 2nd International Forum on Stem Cells November 12-13, 2010 Tianjin, China Stem Cell Network 10th Annual Scientific Meeting November 22-24, 2010 Calgary, Canada Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference December 5-8, 2010 Orlando, United States Biotech Showcase 2011 January 10-12, 2011 San Francisco, United States Stem Cells World Congress January 24-25, 2011 San Diego, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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