ESC & iPSC News Volume 5.34 | Sep 1 2010

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    ESC & iPSC News 5.34, September 1, 2010.
    In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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    TOP STORY

    Hepatoblast-Like Progenitor Cells Derived from Embryonic Stem Cells Can Repopulate Livers of Mice 
    Embryonic stem cell-derived c-Kit(-)EpCAM(+) cells contain a population of hepatoblast-like progenitor cells that can repopulate livers of mice. [Gastroenterology]

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    SCIENCE NEWS

    Applying Stem Cell Technology to Liver Diseases
    Induced pluripotent stem cells (iPS cells) hold promise for cell replacement therapy and modeling human disease. Two independent research groups — at the University of Cambridge, United Kingdom, and the University of California San Francisco — have now shown that both possibilities are true for iPS cell-derived liver cells. [Press release from EurekAlert! discussing online prepublication in the Journal of Clinical Investigation]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Modeling Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cells
    Researchers report a simple and effective platform for hepatocyte generation from patient-specific human induced pluripotent stem cells. [J Clin Invest]

    Induced Pluripotent Stem Cell-Derived Hepatocytes Have the Functional and Proliferative Capabilities Needed for Liver Regeneration in Mice
    In vivo analyses showed that induced pluripotent stem cells were intrinsically able to differentiate into fully mature hepatocytes that provided full liver function. [J Clin Invest]

    Differential Regulation of Proliferation and Differentiation in Neural Precursor Cells by the Jak Pathway
    Results suggest that neuronal precursor cell proliferation and differentiation are differentially regulated by the Jak pathway. [Stem Cells]
     
    Gli1 is an Inducing Factor in Generating Floor Plate Progenitor Cells From Human Embryonic Stem Cells
    Researchers show that forced expression of the transcription factor GLI1 in human embryonic stem cells at the earliest stage of neural induction, resulted in their commitment to floor plate lineage. [Stem Cells]

    A Role for Regulatory T Cells in Acceptance of Embryonic Stem Cell-Derived Tissues Transplanted Across an MHC Barrier
    Spontaneous acceptance of embryonic stem cell-derived tissues mimics the acquired immune privilege induced by co-receptor blockade and is determined by regulatory T cell-mediated suppression. [Stem Cells]

    MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing KLF4
    Researchers sought to uncover novel targets of and shed light on the function of miR-1 in the context of embryonic stem cell differentiation of smooth muscle cells in vitro. [Stem Cells Dev]

    Fetal Stromal Niches Enhance Human Embryonic Stem Cell-Derived Hematopoietic Differentiation and Globin Switch
    Researchers investigated the effects of primary stromal cells from fetal hematopoietic niches and their conditioned media, applied singly or in sequential orders, on induction of human embryonic stem cells, H1, H9 and H14 lines, to hematopoietic stem/progenitor cells. [Stem Cells Dev]

    Modulated Differentiation of Embryonic Stem Cells into Hepatocyte-Like Cells by Coculture with Hepatic Stellate Cells
    Hepatic stellate cells have contrasting effects on embryoid bodies undergoing differentiation and undifferentiated embryonic stem cells, i.e., positive and negative modulation, respectively. [J Biosci Bioeng]

    INDUSTRY NEWS

    Roche and Aileron Enter Multi-Target Alliance to Develop Stapled Peptide Drugs for Diseases Across Multiple Therapeutic Areas
    Aileron Therapeutics and Roche announced that they have entered into a collaboration to discover, develop and commercialize a new class of drugs called Stapled Peptide Therapeutics. [Aileron Therapeutics Press Release]

    Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme
    Sanofi-aventis announced that it has submitted a non-binding proposal to acquire Genzyme in an all-cash transaction valued at approximately $18.5 billion. [Sanofi-aventis Press Release]

    Genzyme Confirms Receipt of Unsolicited Proposal
    Genzyme Corp. confirmed that it has received an unsolicited, non-binding proposal from Sanofi-aventis to acquire all the outstanding shares of Genzyme for $69 per share in cash. The Genzyme board of directors unanimously affirmed its previous rejection of Sanofi’s proposal. [Genzyme Press Release]

    POLICY NEWS

    Obama Administration Appeals Stem Cell Injunction
    The Obama administration appealed a ruling that blocked federal funding of embryonic stem cell research and asked the judge who issued the injunction to put it on hold pending the appeal. [Administration, United States]

    NIH Orders Immediate Shutdown of Intramural Human Embryonic Stem Cell Research
    Responding to a court order, the National Institutes of Health (NIH) ordered intramural researchers studying human embryonic stem cells to shut down their experiments. [National Institutes of Health, United States]

    NIH Asks Judge to Suspend Stem Cell Research Injunction
    Warning of a “devastating impact” on ongoing research, the National Institutes of Health (NIH) asked a federal court to stay a preliminary injunction that last week forced NIH to suspend future grant payments to study human embryonic stem cells (hESC) and shut down its in-house research on hESCs. [National Institutes of Health, United States]

    NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States]

    Status of Applications and Awards Involving Human Embryonic Stem Cells, and Submissions of Stem Cell Lines for Eligibility Consideration (NOT-OD-10-126) [National Institutes of Health, United States]

    Request for Comments on Synthetic Biology (FR Doc. 2010-21359) [Department of Health and Human Services, United States]
     
    Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States]

    Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States]
     
    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States]
     
    National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States]
     
    National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States]
     
    Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations [Center for Biologics Evaluation and Research, Untied States]
     
    Guidance for Industry: Electronic Submission of Lot Distribution Reports for Biological Products [Center for Biologics Evaluation and Research, Untied States]

    Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [FR Doc. 2010-20834] [Food and Drug Administration, United States]

    EVENTS

    International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
    September 11-14, 2010
    Belgirate, Italy

    Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
    September 11-17, 2010
    Hydra, Greece

    Stem Cells USA & Regenerative Medicine Congress 2010
    September 13-15, 2010
    Philadelphia, United States

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
    September 15-17, 2010
    Sydney, Australia

    5th Annual Meeting of the German Society for Stem Cell Research
    September 30-October 2, 2010
    Lübeck, Germany

    5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
    October 5-7, 2010
    Hannover, Germany

    Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine
    October 7, 2010
    Hertfordshire, United Kingdom

    Fraunhofer Life Science Symposium Leipzig 2010
    October 29-30, 2010
    Leipzig, Germany

    BioMalaysia 2010 Conference and Exhibition
    November 2-4, 2010
    Kuala Lumpur, Malaysia

    Select Biosciences 2nd International Forum on Stem Cells
    November 12-13, 2010
    Tianjin, China

    Stem Cell Network 10th Annual Scientific Meeting
    November 22-24, 2010
    Calgary, Canada

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
    December 5-8, 2010
    Orlando, United States

    Biotech Showcase 2011
    January 10-12, 2011
    San Francisco, United States 

    Stem Cells World Congress
    January 24-25, 2011
    San Diego, United States

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

     

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