ESC & iPSC News Volume 5.39 | Oct 6 2010

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    ESC & iPSC News 5.39, October 6, 2010.
    In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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    TOP STORY

    Safe, Efficient Method Reported for Creating and Differentiating Human Pluripotent Stem Cells 
    Researchers report the development of a safe and efficient technology to create human induced pluripotent stem cells. [Press release from Children’s Hospital Boston discussing online prepublication in Cell Stem Cell]

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    SCIENCE NEWS

    University of Michigan Creates the State’s First Human Embryonic Stem Cell Line
    Researchers have created the state’s first human embryonic stem cell line, known as UM4-6. [Press release from the University of Michigan discussing research presented at the World Stem Cell Summit]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
    Researchers describe a simple, nonintegrating strategy for reprogramming cell fate based on administration of synthetic mRNA modified to overcome innate antiviral responses. [Cell Stem Cell]

    Efficient Differentiation of Human Pluripotent Stem Cells into Functional CD34+ Progenitor Cells by Combined Modulation of MEK/ERK and BMP4 Signaling Pathways
    Results suggest that combined modulation of signaling pathways may be an efficient means of differentiating human pluripotent stem cells into functional CD34+ progenitor cells. [Blood]

    Embryonic Stem Cell-Derived Hemangioblasts Remain Epigenetically Plastic and Require PRC1 to Prevent Neural Gene Expression
    Researchers show that the chromatin profile of this important cohort of genes is progressively modified as embryonic stem cells differentiate towards blood-forming precursors. [Blood]

    Proteome of Mouse Oocytes at Different Developmental Stages
    Results provide important knowledge to better understand the molecular mechanisms in early development and may improve the generation of induced pluripotent stem cells. [Proc Natl Acad Sci U S A]

    Memory in Induced Pluripotent Stem Cells: Reprogrammed Human Retinal Pigmented Epithelial Cells Show Tendency for Spontaneous Redifferentiation
    Results show that retinal pigmented epithelial cells can be reprogrammed to pluripotency, and suggest that they often retain a memory of their previous state of differentiation. [Stem Cells]

    Opposing Putative Roles for Canonical and Non-Canonical NFKappaB Signaling on the Survival, Proliferation and Differentiation Potential of Human Embryonic Stem Cells
    The findings, coupled with opposing trends in expression of key components during human embryonic stem cell (hESC) differentiation, suggests a fine and opposing balance between the two branches of NFkappaB signaling pathways and their involvement in two distinct processes: the canonical pathway regulating hESC differentiation and the non-canonical pathway maintaining hESC pluripotency. [Stem Cells]

    Cancer-Related Epigenome Changes Associated with Reprogramming to Induced Pluripotent Stem Cells
    Findings suggest that by studying the process of induced reprogramming, researchers may gain significant insight into the origins of epigenetic gene silencing associated with human tumorigenesis, and add to means of assessing induced pluripotent stem cells for safety. [Cancer Res]

    Efficacy of hESC-MSCs in Knitted Silk-Collagen Scaffold for Tendon Tissue Engineering and Their Roles
    Tissue-engineered tendon can be successfully fabricated through seeding of human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) within a knitted silk-collagen sponge scaffold followed by mechanical stimulation. [Biomaterials]

    Rhythmic Beating of Stem Cell-Derived Cardiac Cells Requires Dynamic Coupling of Electrophysiology and Ca Cycling
    Rhythmic embryonic stem cell-derived cardiocyte automaticity can be achieved by boosting “coupling” factors, such as cAMP/PKA signaling, that enhance interactions between sarcoplasmic reticulum and sarcolemma. [J Mol Cell Cardiol]

    A Novel Stepwise Differentiation of Functional Pancreatic Exocrine Cells from Embryonic Stem Cells
    Researchers developed a differentiation protocol that gradually induced the formation of mouse pancreatic exocrine cells from embryonic stem cells. [Stem Cells Dev]

    INDUSTRY NEWS

    Oakland University and Beaumont Announce Stem Cell Research Partnership
    With the Oakland University William Beaumont School of Medicine set to open with its inaugural class in fall 2011, its parent institutions have launched the Oakland University William Beaumont Institute for Stem Cell and Regenerative Medicine. [Beaumont Hospitals Press Release]

    McLean Researchers Awarded $1.9 Million Grant for Stem Cell, Blood Research
    Researchers at Harvard-Affiliated McLean Hospital have been awarded a $1.9 million National Institutes of Health Director’s Opportunity Award to continue their research into creating human induced pluripotent stem cells using a method aimed at eliminating the risk of cancer and other problems associated with other options such as genome-integrating viral methods. [McLean Hospital Press Release]

    Quicken Founder Gilbert Invests in Stem Cell Research
    Gilbert, founder and chairman of Quicken Loans Inc., told the audience at the World Stem Cell Summit in Detroit that he supports stem cell research and has invested several million dollars in Cellerant Therapeutics, a California-based company. [The Detroit News]

    POLICY NEWS

    Appeals Court Says Stem Cell Funding Can Continue
    An appeals court decided to allow federal funding for human embryonic stem cell (hESC) research to continue while the court considers legal arguments that halted hESC research last month. [Court of Appeals, United States]

    Court Schedule Suggests Stem Cell Lawsuit Won’t Be Resolved Until Late in Year
    The court dates for the lawsuit tying up stem cell research suggest the case won’t be decided until at least Thanksgiving and could take until the end of the year. [Court of Appeals, United States]

    Lawmakers Introduce Bipartisan Legislation to Create Jobs and Promote Investment in Life Sciences
    U.S. Representatives introduced bipartisan legislation that will provide tax incentives for small and mid-sized businesses to invest in life sciences research and development on a targeted basis. The Life Sciences Jobs and Investment Act of 2010 provides an opportunity to enhance medical innovation, life sciences education and job creation in the United States. [House of Representatives, United States]

    NIH and FDA Announce Awards to Advance Regulatory Science
    The National Institutes of Health will award $9.4 million over three years to support four research projects in regulatory science. This research is conducted in partnership with the U.S. Food and Drug Administration, which will contribute approximately $950,000. [National Institutes of Health and Food and Drug Administration, United States]

    FDA Issues Final Rule on Safety Information During Clinical Trials
    The U.S. Food and Drug Administration (FDA) issued a final rule that clarifies what safety information must be reported during clinical trials of investigational drugs and biologics. [Food and Drug Administration, United States]

    NIH Transformative Research Project Awards Hasten Innovation
    The National Institutes of Health will award up to $64 million over five years to encourage exploration of exceptionally innovative and original research ideas that have the potential for extraordinary impact. [National Institutes of Health, United States]

    Clarification of the Submission Date for Applications for Program Projects for Collaborative Research on the Basic Biology of Pluripotency and Reprogramming (P01) (RFA-GM-11-005) (NOT-GM-10-109) [National Institute of General Medical Sciences, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24680) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24549) [National Institutes of Health, United States]
     
    Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-24550) [National Institutes of Health, United States]
     
    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24556) [National Institutes of Health, United States]
     
    Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-24405) [National Institutes of Health, United States] 

    EVENTS

    Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine
    October 7, 2010
    Welwyn Garden City, United Kingdom

    Functional Stem Cell and Regeneration
    October 9-10, 2010
    Kansas City, United States

    18th Annual BioPartnering Europe
    October 10-12, 2010
    London, United Kingdom

    3rd Biobridge “Generation Regeneration” Conference
    October 11, 2010
    Geneva, Switzerland

    New York Stem Cell Foundation 5th Annual Translational Stem Cell Research Conference
    October 12-13, 2010
    New York City, United States

    4th International Symposium Stem Cells, Development and Regulation
    October 12-14, 2010
    Amsterdam, Netherlands

    Stem Cells and Regenerative Medicine – New Solutions to Old Problems
    October 18-20, 2010
    San Antonio, United States

    European Society of Gene and Cell Therapy (ESGCT) 18th Annual Congress
    October 22-25, 2010
    Milan, Italy

    World Stem Cells & Regenerative Medicine Congress Asia 2010
    October 26-28, 2010
    Seoul, Korea

    Fraunhofer Life Science Symposium Leipzig 2010
    October 29-30, 2010
    Leipzig, Germany

    Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
    November 2-3, 2010
    Singapore

    BioMalaysia 2010 Conference and Exhibition
    November 1-3, 2010
    Kuala Lumpur, Malaysia

    Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
    November 12-13, 2010
    Tianjin, China

    The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
    November 15-18, 2010
    Nara, Japan

    8th Annual Commercial Translation of Regenerative Medicine Conference
    November 18-19, 2010
    London, United Kingdom

    Stem Cell Network’s 10th Annual Scientific Meeting
    November 22-24, 2010
    Calgary, Alberta

    Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
    December 5-8, 2010
    Orlando, United States

    Biotech Showcase 2011
    January 10-12, 2011
    San Francisco, USA

    Select Biosciences 5th Annual Stem Cells World Congress
    January 24-25, 2011
    San Diego, United States

    Keystone Symposia-Stem Cells in Development, Tissue Homeostasis and Disease
    January 30-February 4, 2011
    Santa Fe, United States

    Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
    February 23-25, 2011
    San Francisco, United States

    American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
    March 3-6, 2011
    Vancouver, Canada

    Stem Cells, Cancer and Metastasis (C4)
    March 6-11, 2011
    Dillon, United States

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

     



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