CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Directed Differentiation of Human Pluripotent Stem Cells Into Intestinal Tissue In Vitro Researchers establish a robust and efficient process to direct the differentiation of human pluripotent stem cells into intestinal tissue in vitro using a temporal series of growth factor manipulations to mimic embryonic intestinal development. [Nature] Genomic Safe Harbors Permit High Beta-Globin Transgene Expression in Thalassemia Induced Pluripotent Stem Cells Researchers describe a strategy to genetically modify human induced pluripotent stem cells at ‘safe harbor’ sites in the genome, which fulfill five criteria based on their position relative to contiguous coding genes, microRNAs and ultraconserved regions. [Nat Biotechnol] Tracking and Assessing the Rise of State-Funded Stem Cell Research In the eight-year period preceding the most recent NIH guidelines, only a small number of cell lines could be studied with federal funds. During this time, six states — California, Connecticut, Illinois, Maryland, New Jersey and New York — took on a role typically played by the NIH and created funding programs specifically designed to support stem cell research, including human embryonic stem cell research. [Nat Biotechnol] LIF-Independent JAK Signaling to Chromatin in Embryonic Stem Cells Uncovered From an Adult Stem Cell Disease Researchers show that mouse embryonic stem cells carrying the human JAK2V617F mutation were able to self-renew in chemically defined conditions without cytokines or small-molecule inhibitors, independently of JAK signaling through the STAT3 or phosphatidylinositol-3-OH kinase pathways. [Nat Cell Biol] Monocytic Cells Derived From Human Embryonic Stem Cells and Fetal Liver Share Common Differentiation Pathways and Homeostatic Functions Researchers show that monocytic cells derived from human embryonic stem cells and fetal liver follow a differentiation pathway different to that of adult cells, leading to specific functions. [Blood] Switching of the Core Structures of Glycosphingolipids From Globo- and Lacto- to Ganglio-Series Upon Human Embryonic Stem Cell Differentiation In addition to the well-known human embryonic stem cell (hESC)-specific markers stage-specific embryonic antigen 3 (SSEA-3) and SSEA-4, researchers identified several globosides and lacto-series glycosphingolipids, previously unrevealed in hESCs, including Gb4Cer, Lc4Cer, fucosyl Lc4Cer, Globo H, and disialyl Gb5Cer. [Proc Natl Acad Sci U S A] A Regulatory Circuitry Comprised of miR-302 and the Transcription Factors OCT4 and NR2F2 Regulates Human Embryonic Stem Cell Differentiation Researchers show that the transcriptional factors OCT4 and NR2F2 (COUP-TFII) and the miRNA miR-302 are linked in a regulatory circuitry that critically regulate both pluripotency and differentiation in human embryonic stem cells. [EMBO J] Large-Scale Phosphoproteome Profiles Comprehensive Features of Mouse Embryonic Stem Cells This work provides an overview of phosphorylation in mouse embryonic stem (mES) cells and is a valuable resource for the future understanding of basic biology in mES cells. [Mol Cell Proteomics] Choice of Random Rather Than Imprinted X Inactivation in Female Embryonic Stem Cell-Derived Extra-Embryonic Cells Researchers tested the mode of X inactivation during the differentiation of female mouse embryonic stem cells derived from the inner cell mass of blastocyst-stage embryos toward trophectoderm and primitive endoderm lineages induced by artificial activation of transcription factor genes Cdx2 and Gata6, respectively. [Development] Generation of HIV-1 Resistant and Functional Macrophages from Hematopoietic Stem Cell-Derived Induced Pluripotent Stem Cells Researchers demonstrate the ability of induced pluripotent stem cells (iPSCs) to develop into HIV-1 resistant immune cells and highlight the potential use of iPSCs for HIV gene and cellular therapies. [Mol Ther] Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage Researchers report the in vitro differentiation of mouse induced pluripotent stem cells into a keratinocyte lineage through sequential applications of retinoic acid and bone-morphogenetic protein-4 and growth on collagen IV-coated plates. [J Invest Dermatol] Influencing Hematopoietic Differentiation of Mouse Embryonic Stem Cells Using Soluble Heparin and Heparan Sulfate Saccharides Embryonic stem cells (ESCs) derived from Ext1-/- embryos are unable to differentiate into hematopoietic lineages, instead retaining ESC marker expression throughout embryoid body culture. However hematopoietic differentiation can be restored by the addition of soluble heparin. [J Biol Chem]
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INDUSTRY NEWS States Now Fund Majority of Human Embryonic Stem Cell Research States, not the federal government, now fund the majority of human embryonic stem cell research conducted in the United States, according to a recent study. [Press release from the Georgia Institute of Technology discussing online prepublication in Nature Biotechnology] Melbourne Receives $21 Million for Pioneering Stem Cell Research The University of Melbourne has been awarded $21 million from the Australian Research Council to establish Stem Cells Australia, an initiative that will position Australia as a major world player in stem cell research. [University of Melbourne Press Release] University of Toronto-Hosted Project to Develop Regenerative Medicine Products Is Awarded $15 Million From the Federal Government A University of Toronto-hosted project to develop products to treat devastating health conditions such as heart disease, diabetes, cancer and spinal cord injuries, The Centre for Commercialization of Regenerative Medicine, has been awarded $15 million by the federal government. [University of Toronto Press Release] $26 Million Boosts Stem Cell Research A new $26.5-million stem cell research facility to be built at the University of Alberta will keep Edmonton at the forefront of regenerative medicine for patients with diabetes, burns, premature lungs and Parkinson’s disease. [The Edmonton Journal] ReNeuron Announces Fundraising ReNeuron Group plc announced that it has raised £10 million, before expenses. [ReNeuron Group plc Press Release] Harvard Bioscience Files Two Major Patents in Field of Regenerative Medicine Harvard Bioscience, Inc. has filed two major patents in the field of regenerative medicine, the first covering 61 claims for its stem cell therapy injectors and the second for 338 claims for bioreactors for organ growth. [Harvard Bioscience, Inc. Press Release] Sanofi-aventis Appoints Dr. Elias Zerhouni, President, Global Research & Development Sanofi-aventis announced the appointment of Dr. Elias Zerhouni as President, Global Research & Development, covering Medicines and Vaccines, effective January 1, 2011. [Sanofi-aventis Press Release]
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POLICY NEWS NIH Panel Approves More Stem Cell Lines A key advisory panel to the National Institutes of Health (NIH) director has recommended that four additional human embryonic stem cell lines be added to those eligible for U.S. funding. [National Institutes of Health, United States] House Approves Flat 2011 Budget for Most Science Agencies The three federal agencies that support the vast majority of academic research would receive no more money in 2011 than in 2010 under a spending bill that narrowly passed the House of Representatives. [House of Representatives, United States] CIRM-MRC Human Somatic Cell Nuclear Transfer Workshop Report Report of an Medical Research Council (MRC) and California Institute for Regenerative Medicine (CIRM) workshop to examine human somatic cell nuclear transfer and its role in stem cell research, summarizing the state of the global research effort in this area. [Medical Research Council, United Kingdom] Public Consultation on Personnel Reliability and Culture of Responsibility Issues (FR Doc. 2010-31056) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-31058) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-31057) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-31054) [National Institutes of Health, United States] Guidance for the Public, FDA Advisory Committee Members, and FDA Staff: The Open Public Hearing at FDA Advisory Committee Meetings; Availability [Docket No. FDA-2005-D-0072] (formerly Docket No. 2005D-0042) [Food and Drug Administration, United States]
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EVENTS Pharmacology in Stem Cells Research and Regenerative Medicine December 17, 2010 London, United Kingdom The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine December 17-19, 2010 Guangzhou, China Biotech Showcase 2011 January 10-12, 2011 San Francisco, United States 5th Annual Stem Cells and Regenerative Medicine World Congress January 24-25, 2011 San Diego, United States Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease January 30-February 4, 2011 Santa Fe, United States Stem Cell Research Forum of India 2nd Annual Meeting February 8-11, 2011 Bangalore, India SMi Stem Cells 2011 – Innovation and Commercialisation February 23-24, 2011 London, United Kingdom Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011 February 23-25, 2011 San Francisco, United States Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture February 28-March 2, 2011 Munich, Germany 6th Annual Stem Cell Summit March 1, 2011 New York, United States American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada Keystone Symposia: Stem Cells, Cancer and Metastasis March 6-11, 2011 Dillon, United States PITTCON Conference & Expo 2011 March 13-18, 2011 Atlanta, United States 15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications March 16-19, 2011 Hilton Head Island, United States StemCONN 11 March 22, 2011 Farmington, United States United Kingdom National Stem Cell Network 2011 Annual Scientific Conference March 30-April 1, 2011 York, United Kingdom Clinical Gene Transfer: State of the Art Conference and e-Chips European Congress on Human iPS Cells April 7-9, 2011 Paris, France World Stem Cells & Regenerative Medicine Congress 2011 May 9-11, 2011 London, United Kingdom American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting May 18-22, 2011 Seattle, United States 13th Annual C21 BioVentures May 24-26, 2011 Napa, United States NEW Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference June 7-10, 2011 Granada, Spain NEW International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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