Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations The robust capability to genetically correct disease-causing point mutations in patient-derived human induced pluripotent stem cells (hiPSCs) represents significant progress for basic biomedical research and an advance toward hiPSC-based cell replacement therapies. [Cell] Dynamic Transcriptional Events in Embryonic Stem Cells Mediated by the Super Elongation Complex In this study, investigators performed global genomic analyses in murine embryonic stem cells and in human cells in response to activation signals. [Genes Dev] The Promotion of Stemness and Pluripotency Following Feeder-Free Culture of Embryonic Stem Cells on Collagen-Grafted 3-Dimensional Nanofibrous Scaffold In this study, scientists analyzed the maintenance of stemness and pluripotency of the mouse embryonic stem cell following feeder-free culture on collagen-grafted polyethersulfone electrospun nanofibrous scaffold. [Biomaterials] Generation of Pancreatic Insulin-Producing Cells from Rhesus Monkey Induced Pluripotent Stem Cells Here investigators tried to generate insulin-producing cells from rhesus monkey induced pluripotent stem cells. [Diabetologia] Depletion of Kcnq1ot1 Non-Coding RNA Does Not Affect Imprinting Maintenance in Stem Cells Here, scientists investigated the mouse Kcnq1ot1 non-coding RNA and its role in imprinted gene regulation during preimplantation development by utilizing mouse embryonic and extra-embryonic stem cell models. [Development] DLK1 Promotes Neurogenesis of Human and Mouse Pluripotent Stem Cell-Derived Neural Progenitors via Modulating Notch and BMP Signaling In this study, scientists investigated the ability of Dlk1 in modulating the maintenance and differentiation of human and mouse embryonic stem cell-derived neural progenitors. [Stem Cell Rev] Tet1 and 5-Hydroxymethylation: A Genome-Wide View in Mouse Embryonic Stem Cells Through integrative analyses of datasets from different groups, researchers revealed the common Tet1 and 5-hydroxymethylcytosine targets in undifferentiated mouse embryonic stem cells, which suggest that Tet1 may play a key role in orchestrating the balance between pluripotent and lineage committed states. [Cell Cycle] Stage Prediction of Embryonic Stem Cell Differentiation from Genome-Wide Expression Data Investigators used whole-genome transcription data and several data projection methods to infer differentiation stage prediction models for embryonic cells. [Bioinformatics] E-Cadherin Acts as a Regulator of Transcripts Associated with a Wide Range of Cellular Processes in Mouse Embryonic Stem Cells In this study, scientists have assessed global transcript expression in E-cadherin null embryonic stem cells cultured in either the presence or absence of LIF and compared these to the parental cell line wtD3. [PLoS One] |