Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells Using the murine model of tyrosinemia type 1 (fumarylacetoacetate hydrolase [FAH] deficiency; FAH-/- mice) as a paradigm for orphan disorders, investigators evaluated fibroblast-derived FAH-/--induced pluripotent stem cells as targets for gene correction in combination with the tetraploid embryo complementation method. [PLoS Biol] Mouse Embryonic Stem Cell-Derived Thymic Epithelial Cell Progenitors Enhance T-Cell Reconstitution After Allogeneic Bone Marrow Transplantation Here, investigators show that transplantation of mouse embryonic stem cell-derived thymic epithelial cell progenitors results in the efficient establishment of thymocyte chimerism and subsequent generation of naïve T cells in both young and old recipients of allogeneic bone marrow transplantation. [Blood] Lineage Restricted Progenitors for the Repopulation of Decellularized Heart In the present work, scientists compared the differentiation potential of human embryonic stem cells (hESCs) and human mesendodermal cells derived from hESCs, in decellularized hearts under static culture. [Biomaterials] Rapid and Efficient Generation of Functional Motor Neurons from Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes Researchers evaluated the motor neuron (MN) gene expression profile of retinoic acid/ sonic hedgehog-differentiated human embryonic stem cells to identify rate-limiting factors involved in MN development. [Mol Ther] Human Embryonic Stem Cell-Derived Neurons Establish Region-Specific, Long-Range Projections in the Adult Brain Investigators addressed the potential of human embryonic stem cell-derived long-term self-renewing neuroepithelial stem cells to establish axonal projections after transplantation into the adult rodent brain. [Cell Mol Life Sci] A Comparative Analysis of DNA Methylation Across Human Embryonic Stem Cell Lines Scientists performed a comparative analysis of the genome wide DNA methylation profiles from three human embryonic stem cell lines. [Genome Biol] Learning Biomarkers of Pluripotent Stem Cells in Mouse Investigators assembled gene expression data of pluripotent stem cells and non-pluripotent cells from the mouse. [DNA Res] Three-Dimensional Co-Culture Facilitates the Differentiation of Embryonic Stem Cells into Mature Cardiomyocytes Scientists develop a novel strategy that enhances cardiomyocyte differentiation of embryonic stem cells in collagen matrix three-dimensional culture combined with indirect cardiac fibroblasts co-culture. [J Cell Biochem] |