ESC & iPSC News Volume 6.30 | Aug 3 2011

Neuronal Maturation Defect in Induced Pluripotent Stem Cells from Patients with Rett Syndrome
In this work, scientists applied a recently developed reprogramming approach to generate a novel in vitro human Rett syndrome model. [Proc Natl Acad Sci U S A]

HED: Controlling Induced Pluripotent Stem Cell Transformation: It’s in the Sugar
Providing new insight into the biomechanics of regenerative medicine, researchers have shown how cellular metabolism facilitates stem cell procurement from regular tissue. [Press release from Mayo Clinic Minnesota discussing online prepublication in Cell Metabolism]

Investigators Claim FOXO1 Plays Critical Role in hESC Pluripotency
Scientists claim the forkhead box O (FOXO) transcription factor FOXO1 is an essential component of the cellular control mechanism that maintains pluripotency in human embryonic stem cells (hESCs). [Press release from Genetic Engineering & Biotechnology News discussing online prepublication in Nature Cell Biology]

Regulation of the MDM2-P53 Pathway and Tumor Growth by PICT1 via Nucleolar RPL11
To clarify the function of PICT1, researchers generated Pict1-deficient mice and embryonic stem cells. [Nat Med]

FOXO1 Is An Essential Regulator of Pluripotency in Human Embryonic Stem Cells
Investigators show that forkhead box O 1 (FOXO1) is essential for the maintenance of human embryonic stem cell (ESC) pluripotency, and that an orthologue of FOXO1 exerts a similar function in mouse ESCs. [Nat Cell Biol]

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming
The energetic infrastructure of somatic cells transitions into a required glycolytic metabotype to fuel induction of pluripotency. [Cell Metab]

Cardiomyocytes Obtained from Induced Pluripotent Stem Cells with Long-QT Syndrome 3 Recapitulate Typical Disease-Specific Features In Vitro
The aim of this study was to establish as a proof of principle the disease-specific cardiomyocytes from a mouse model with long-QT syndromes 3 by use of induced pluripotent stem cells and to demonstrate that the mutant cardiomyocytes display the characteristic pathophysiological features in vitro. [Circ Res]

Efficient Derivation of NPCs, Spinal Motor Neurons and Midbrain Dopaminergic Neurons from hESCs at 3% Oxygen
This protocol has been designed to generate neural precursor cells (NPCs) from human embryonic stem cells (hESCs) using a physiological oxygen level of 3% and chemically defined conditions. [Nat Protoc]

Creation of Mouse Embryonic Stem Cell-Derived Cardiac Cell Sheets
In the present study, scientists created cell sheets of mouse embryonic stem cell-derived cardiomyocytes after expansion in three-dimensional stirred suspension cultures. [Biomaterials]

Epigenetic Control of Embryonic Stem Cell Differentiation
By deriving embryonic stem cells from the early embryo, researchers can preserve the highly specialized genome organization and this has permitted several detailed investigations into the molecular basis of pluripotency. [Stem Cell Rev]

Epithelial Cell Adhesion Molecule Complex Proteins Promote Transcription Factor-Mediated Pluripotency Reprogramming
Investigators demonstrate that epithelial cell adhesion molecule and its associated protein, Cldn7, play a critical role in reprogramming. [J Biol Chem]

Down-Regulation of H19 Improves the Differentiation Potential of Mouse Parthenogenetic Embryonic Stem Cells
In the present study scientists found that H19 was the most deregulated imprinted gene in parthenogenetic embryonic stem cells with more than 6-fold over-expression compared to biparental embryonic stem cells. [Stem Cells Dev]

Johns Hopkins Scientists Begin First-Of-Its-Kind Research to Create Blood Platelets from Stem Cells to Study Genetics of Blood Clotting Disorders
Johns Hopkins scientists have launched a pioneering research program to create, for the first time, human platelet cells from stem cells in order to study inherited blood clotting abnormalities ranging from clots that cause heart attacks and stroke to bleeding disorders. [Johns Hopkins Medicine Press Release]

NIH Appoints Director of Intramural Center for Regenerative Medicine
National Institutes of Health (NIH) Director Francis S. Collins, M.D., Ph.D., has announced the appointment of Mahendra S. Rao, M.D., Ph.D. as the director for the new NIH Intramural Center for Regenerative Medicine. [National Institutes of Health Press Release]

Report on Regenerative Medicine by the Office for Life Sciences/Department of Health Published
The Office for Life Sciences and the Department of Health published a report into the regenerative medicine field on 18 July 2011. [Office for Life Sciences, United Kingdom]

Researchers Question NSF’s Changes to Merit Review Criteria
At a congressional hearing, a university leader added to concerns from the scientific community that the draft changes proposed in June by the National Science Board (NSB) confuse further, rather than clarify, the NSF’s so-called Criterion Two. [National Science Board, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc No: 2011-18894) [National Institutes of Health, United States]

Human Subjects Research Protections: Enhancing Protections for Research Subjects and Reducing Burden, Delay, and Ambiguity for Investigators [FR Doc No: 2011-18792] [Food and Drug Administration, United States]

NEW Regenerative Medicine: New Approaches to Healthcare
September 28, 2011
New York, United States

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Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

PhD Research Position in the Department of Biological Chemistry (Weizmann Institute of Science)

Career Development Fellows (Medical Research Council)

Research Group Leader – Human Epigenomics and Stem Cells (MRC Clinical Sciences Centre)

Postdoctoral Position (Nanyang Technological University)

Human Embryonic Stem Cell Biologist (Matchtech)

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