ESC & iPSC News Volume 6.34 | Aug 31 2011

Different Telomere-Length Dynamics at the Inner Cell Mass Versus Established Embryonic Stem (ES) Cells
Here scientists address whether hyper-long telomeres are a natural property of pluripotent stem cells or whether it is a characteristic acquired by the in vitro expansion of ES cells. [Proc Natl Acad Sci U S A] Abstract

Dynamic Chromatin States in Human ES Cells Reveal Potential Regulatory Sequences and Genes Involved in Pluripotency
In order to better understand the role of epigenetic mechanisms in pluripotency, researchers have examined the dynamics of chromatin modifications genome-wide in human embryonic stem (ES) cells undergoing differentiation into a mesendodermal lineage. [Cell Res] Abstract

Mice Generated from Tetraploid Complementation Competent iPS Cells Show Similar Developmental Features as Those from Embryonic Stem Cells But Are Prone to Tumorigenesis
Investigators have demonstrated that fully reprogrammed induced pluripotent cells (iPSCs) were capable of producing full-term mice via the tetraploid complementation method, yet a thorough postnatal development evaluation of iPS mice is still lacking. [Cell Res] Abstract

The Effects of Covalently Immobilized Hyaluronic Acid Substrates on the Adhesion, Expansion, and Differentiation of Embryonic Stem Cells for In Vitro Tissue Engineering
Scientists investigated the in vitro effects of the molecular weight of hyaluronic acid on the maintenance of the pluripotency and proliferation of murine embryonic stem cells. [Biomaterials] Abstract

Endogenous APOBEC3B Restricts Long Interspersed Element-1 Retrotransposition in Transformed Cells and Human Embryonic Stem Cells
Here, researchers show that HeLa cells express endogenous APOBEC3B (A3B) and A3C, whereas human embryonic stem cells express A3B, A3C, A3DE, A3F, and A3G. [J Biol Chem] Abstract

Hypoxia Enhances the Generation of Retinal Progenitor Cells from Human Induced Pluripotent and Embryonic Stem Cells
In this study, investigators examined the effect of mimicking the physiological O^₂ tension (2%) on the generation of retinal progenitor cells from human induced pluripotent stem cells and human embryonic stem cells. [Stem Cells Dev] Abstract

A Model of Early Human Embryonic Stem Cell Differentiation Reveals Inter- and Intracellular Changes Upon Transition to Squamous Epithelium
Here, researchers characterize an in vitro model that permits analysis of the earliest steps in the transition of human embryonic stem cell colonies to squamous epithelium upon basic fibroblast growth factor (bFGF or FGF2) withdrawal. [Stem Cells Dev] Abstract

Comparative Transcriptome Analysis of Human Trophectoderm and Embryonic Stem Cell-Derived Trophoblasts Reveal Key Participants in Early Implantation
Herein scientists have investigated the transcriptome of mural trophectoderm (TE) cells from 13 human blastocysts and compared these with those of human embryonic stem cell-derived-TE. [Biol Reprod] Abstract

Controlling Cells’ Environments: A Step Toward Building Much-Needed Tissues and Organs
With stem cells so fickle and indecisive that they make Shakespeare’s Hamlet pale by comparison, scientists described an advance in encouraging stem cells to make decisions about their fate. [Press release from the American Chemical Society discussing research presented at the 242nd National Meeting & Exposition for the American Chemical Society, Denver] Press Release

BD Biosciences Announces Winners of Research Grant Program
BD Biosciences has announced the latest round of winners of the BD Biosciences Research Grant Program. [BD Worldwide] Press Release

The Jackson Laboratory Appoints Edison Liu, M.D., as New President and CEO
Edison Liu, M.D. will be the new president and chief executive officer of The Jackson Laboratory. [The Jackson Laboratory] Press Release

HHS Tightens Financial Conflict of Interest Rules for Researchers
The U.S. Department of Health and Human Services (HHS) issued an updated Final Rule on conflict of interest, providing a framework for identifying, managing, and ultimately avoiding investigators’ financial conflicts of interest. [US Department of Health and Human Services, United States] Press Release

Cutting Back in Academia
Upon the request of Congress, a US National Academy of Sciences panel is drafting a plan to help state universities deal with continuing budget cuts. [US National Academy of Sciences, United States] Press Release

Scientists Promised ‘One Voice’ in European Policy
A new Brussels-based group, ScienceEurope, is now positioning itself as the scientists’ champion in the fight to sway decision-makers. [ScienceEurope, Belgium] Press Release

NIH Releases Best Practices for Combining Qualitative and Quantitative Research
The National Institutes of Health released recommendations or best practices for scientists conducting mixed methods health research. [National Institutes of Health, United States] Press Release

Issuance of the Final Rule – Responsibility of Applicants for Promoting Objectivity in Research for which Public Health Service Funding is Sought and Responsible Prospective Contractors [NOT-OD-11-109] [National Institutes of Health, United States]

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Postdoctoral Scientist (Yale University)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

Postdoctoral Scholar (University of California, Irvine)

PhD Research Position in the Department of Biological Chemistry (Weizmann Institute of Science)

Research Group Leader – Human Epigenomics and Stem Cells (MRC Clinical Sciences Centre)

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