ESC & iPSC News Volume 6.36 | Sep 14 2011

Derivation of Haploid Embryonic Stem Cells from Mouse Embryos
Here scientists describe haploid mouse embryonic stem cells and show their application in forward genetic screening. [Nature] Abstract | Press Release

Midbody Accumulation through Evasion of Autophagy Contributes to Cellular Reprogramming and Tumorigenicity
Here researchers show that midbody derivatives are inherited asymmetrically by the daughter cell with the older centrosome. They selectively accumulate in stem cells, induced pluripotent stem cells and potential cancer ‘stem cells’ in vivo and in vitro. [Nat Cell Biol] Abstract | Press Release

Modeling Familial Alzheimer’s Disease with Induced Pluripotent Stem Cells
Here investigators generate induced pluripotent stem cells from fibroblasts of familial Alzheimer’s disease patients with mutations in presenilin 1 (A246E) and presenilin 2 (N141I), and characterize the differentiation of these cells into neurons. [Hum Mol Genet] Abstract

The Effects of the Physical Properties of Culture Substrates on the Growth and Differentiation of Human Embryonic Stem Cells
Here researchers show that human embryonic stem cell culture conditions can be optimized by utilizing polyethylene terephthalate membranes whose defined pore densities determine membrane surface hardness. [Biomaterials] Abstract

Pluripotent Stem Cell-Derived Cardiac Tissue Patch with Advanced Structure and Function
In this study, scientists introduced 3D cell alignment cues in a fibrin-based hydrogel matrix to engineer highly functional cardiac tissues from genetically purified mouse embryonic stem cell-derived cardiomyocytes and cardiovascular progenitors. [Biomaterials] Abstract

Genomic Binding of Pol III Transcription Machinery and Relationship with TFIIS Transcription Factor Distribution in Mouse Embryonic Stem Cells
Researchers investigated the distribution of RNA polymerase (Pol) III and its associated transcription factors on the genome of mouse embryonic stem cells using a highly specific tandem ChIP-Seq method. [Nucleic Acids Res] Abstract

Insulin-Like Growth Factor 2 Promotes Osteogenic Cell Differentiation in Parthenogenetic Murine Embryonic Stem Cells
Investigators present data demonstrating that osteogenic differentiation of parthenogenetic embryonic stem cells can be promoted by insulin-like growth factor 2. [Tissue Eng Part A] Abstract

A Virus-Free Poly-Promoter Vector Induces Pluripotency in Quiescent Bovine Cells Under Chemically Defined Conditions of Dual Kinase Inhibition
Here, investigators report the first generation of bovine induced pluripotent stem cell-like cells following transfection with a novel virus-free poly-promoter vector. [PLoS One] Abstract | Press Release

Scottish Stem Cell Scientists to Benefit from New Research Fund
Stem cell research in Scotland is set to receive an extra boost with the launch of a new Scottish stem cell research fund on 13 September 2011. [UK Stem Cell Foundation] Press Release

Australia, Singapore Pledge Commitment to Further Scientific Collaboration
Singapore’s Agency for Science, Technology and Research and Australia’s National Health and Medical Research Council have signed a Memorandum of Understanding to promote exchange between the two countries in the areas of health and medical research. [Agency for Science, Technology and Research] Press Release

Stem Cell Efforts to Treat Neurological Disease Bolstered With $4.5 Million
The laboratory headed by Steven Goldman, M.D., Ph.D. has received $4.5 million in new funding to further its efforts to use stem cells and related molecules to treat several feared disorders for which there are currently no cures. [University of Rochester Medical Center] Press Release

New Patent Law Could Change How Academics Commercialize Discoveries
The U.S. Senate voted 89-9 to approve the American Invents Act (H.R. 1249), ending a 6-year battle over how best to reform a patent system beset by increasing delays and costly litigation. [U.S. Senate, United States] Press Release

NIH Centre Faces Spell in Limbo
Francis Collins, director of the US National Institutes of Health (NIH), is in danger of missing a self-imposed deadline for his hallmark priority: establishing an NIH centre dedicated to speeding new treatments from the lab to the clinic. [National Institutes of Health, United States] Press Release

Turkish Science Academy Fights Government Changes
The Turkish Academy of Sciences is battling what it sees as a power grab by the Turkish government. [Turkish Academy of Sciences, Turkey] Press Release

NEW VI Brazilian Congress on Stem Cells and Cell Therapy
September 28-October 1, 2011
Salvador da Bahia, Brazil

NEW 1st Annual Congress on Stem Cell Research
September 28-October 2, 2011
Sapanca, Turkey

Visit our events page to see a complete list of events in the ESC & iPSC community.

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Postdoctoral Fellow/Research Scientist (Stem Cell Research) (Institute of Bioengineering and Nanotechnology)

Postdoctoral Scientist (Yale University)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

Postdoctoral Scholar (University of California, Irvine)

PhD Research Position in the Department of Biological Chemistry (Weizmann Institute of Science)

Research Group Leader – Human Epigenomics and Stem Cells (MRC Clinical Sciences Centre)

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