Reduced Collagen Deposition in Infarcted Myocardium Facilitates Induced Pluripotent Stem Cell Engraftment and Angiomyogenesis for Improvement of Left Ventricular Function The purpose of this study was to assess the effect of scar tissue composition on engraftment of progenitor cells into infarcted myocardium. [J Am Coll Cardiol] Abstract Normal Collagen and Bone Production by Gene-Targeted Human Osteogenesis Imperfecta iPSCs Results demonstrate that the combination of gene targeting and induced pluripotent stem cell (iPSC) derivation can be used to produce potentially therapeutic cells from patients with genetic disease. [Mol Ther] Abstract Polypyrimidine Tract-Binding Protein Regulates the Cell Cycle through IRES-Dependent Translation of CDK11p58 in Mouse Embryonic Stem Cells The present study shows that polypyrimidine tract-binding protein promotes M phase progression by the direct repression of CDK11p58 internal ribosome entry site (IRES) activity in embryonic stem cells. [Cell Cycle] Abstract Translating Human Embryonic Stem Cells from 2D to 3D Cultures in a Defined Medium on Laminin and Vitronectin Coated Surfaces The present study describes a system with defined conditions that are capable of supporting the long-term 2D culture of human embryonic stem cells, and the transposing of these conditions to 3D microcarrier cultures. [Stem Cells Dev] Abstract Exacerbation of Oxidative Stress-Induced Cell Death and Differentiation in Induced Pluripotent Stem Cells Lacking Heme Oxygenase-1 Results demonstrate that a lack of heme oxygenase-1 renders induced pluripotent stem cells more prone to oxidative stress-induced cell death and differentiation. [Stem Cells Dev] Abstract Hypoxia Enhances the Generation of Retinal Progenitor Cells from Human Induced Pluripotent and Embryonic Stem Cells In this study, researchers examined the effect of mimicking the physiological O2 tension (2%) on the generation of retinal progenitor cells from human induced pluripotent stem cells and human embryonic stem cells. [Stem Cells Dev] Abstract Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology Here investigators describe a simple and robust protocol for the generation of fibrin-based human engineered heart tissue in a 24-well format using an unselected population of differentiated human embryonic stem cells containing 30–40% α-actinin-positive cardiac myocytes. [PLoS One] Abstract Human Embryonic Stem Cells Derived from Embryos at Different Stages of Development Share Similar Transcription Profiles To examine whether human embryonic stem cell (hESC) lines derived from two developmental stages of the embryo differ in gene expression, scientists have subjected three blastomere-derived hESC lines and two ICM-derived hESC lines grown under identical culture conditions to transcriptome analysis using gene expression arrays. [PLoS One] Abstract |