ESC & iPSC News Volume 7.15 | Apr 18 2012

Tissue-Specific Splicing of an Ndufs6 Gene-Trap Insertion Generates a Mitochondrial Complex I Deficiency-Specific Cardiomyopathy
Scientists generated a mitochondrial complex I-deficient mouse model by knockdown of the Ndufs6 gene using a gene-trap embryonic stem cell line. [Proc Natl Acad Sci USA] Abstract

MicroRNAs Regulate p21Waf1/cip1 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells
Investigators show that the human embryonic stem cell (hESC)-enriched microRNA family miR-302 directly contributes to regulation of p21 expression in hESCs and thus demonstrate a novel function for miR-302s in hESCS. [Stem Cells] Abstract

Lmx1a Allows Context-Specific Isolation of Progenitors of GABAergic or Dopaminergic Neurons During Neural Differentiation of Embryonic Stem Cells
The authors generated a reporter embryonic stem cell (ESC) line for Lmx1a and used it to track differentiation and extract neural progenitors from differentiating mouse ESCs. [Stem Cells] Abstract

Identification of Differentially Expressed Non-Coding RNAs in Embryonic Stem Cell Neural Differentiation
To characterize the entire small non-coding RNA transcriptome involved in the differentiation of mouse embryonic stem (ES) cells into neural cells, researchers have generated three specialized ribonucleo-protein particle-derived cDNA libraries from pluripotent ES cells, neural progenitors and differentiated neural cells. [Nucleic Acids Res] Abstract

Induced Pluripotent Stem Cells without c-Myc Attenuate Acute Kidney Injury via Down-Regulating the Signaling of Oxidative Stress and Inflammation in Ischemia-Reperfusion Rats
Researchers evaluated the therapeutic effect of induced pluripotent stem cells without exogenously introduced c-Myc on ischemia-reperfusion-induced acute kidney injury. [Cell Transplant] Abstract

Cyclin A1 Is Essential for Setting the Pluripotent State and Reducing Tumorigenicity of iPS Cells
Researchers compared induced pluripotent stem (iPS) cells to embryonic stem cells in search for proteins that may improve pluripotency of iPS cells. [Stem Cells Dev] Abstract

Distinct Gene Expression Signatures in Human Embryonic Stem Cells Differentiated Towards Definitive Endoderm at Single-Cell Level
Researchers differentiated human embryonic stem cells towards definitive endoderm using three different activin A based treatments. [Methods] Abstract

Generation of Male Germ Cells from Induced Pluripotent Stem Cells (iPS Cells): An In Vitro and In Vivo Study
Scientists investigated the differentiation potential of mouse iPS cells into spermatogonial stem cells and late-stage male germ cells. [Asian J Androl] Abstract

ACT Announces Second Patient with Dry AMD Treated in U.S. Clinical Trial with RPE Cells Derived from Embryonic Stem Cells
Advanced Cell Technology, Inc. (ACT) announced that the second patient was dosed in the Company’s Phase I/II trial for dry age-related macular degeneration (dry AMD) using retinal pigment epithelial (RPE) cells derived from human embryonic stem cells. The patient is recovering uneventfully. [Advanced Cell Technology, Inc.] Press Release

VistaGen Licenses Breakthrough Stem Cell Culture Technology to Speed Development of Drug Screening and Cell Therapy for Immune System Disorders
VistaGen Therapeutics, Inc. has licensed breakthrough stem cell culture technology from the McEwen Centre for Regenerative Medicine located at the University Health Network in Toronto, Canada. [VistaGen Therapeutics, Inc.] Press Release

Stem Cell Agency Unveils Strategic Partnership Fund to Increase Investment and Engagement with Industry in Stem Cell Therapies for Patients
The California Institute for Regenerative Medicine (CIRM) is committing up to $30 million to a Strategic Partnership Awards Initiative to attract industry engagement and investment in CIRM-funded stem cell research. [California Institute for Regenerative Medicine] Press Release

China’s Stem-Cell Rules Go Unheeded
Three months after the Chinese health ministry ramped up its efforts to enforce a ban on the clinical use of unapproved stem-cell treatments, an investigation reveals that businesses around the country are still charging patients thousands of dollars for these unproven therapies. [Chinese Health Ministry, China]
Press Release

Texas Passes Stem-Cell Regulations
The Texas Medical Board approved regulations that are claimed to ensure safe clinical use of stem cells and other “investigational agents”. The regulations, however, have been criticized as too permissive and opening the door for the sale of dubious treatments. [Texas Medical Board, United States] Press Release

NEW ISEH – Society for Hematology and Stem Cells: 41st Annual Scientific Meeting
August 23-26, 2012
Amsterdam, Netherlands

NEW Stem Cells USA & Regenerative Medicine Congress 2012
September 20-21, 2012
Boston, United States

Visit our events page to see a complete list of events in the ESC & iPSC community.

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Postdoctoral Position – Stem Cell Research (SPIN PhD College)

Lecturer and Postdoctoral Positions – Stem Cell, Telomere Biology, and Bioinformatics (Sun Yat-Sen University)

Postdoctoral Fellow – Induced Neurogenesis (University of Texas Southwestern Medical Center)

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