Induced Pluripotent Stem Cells from Patients with Huntington’s Disease Show CAG-Repeat-Expansion-Associated Phenotypes Researchers reported the generation and characterization of 14 induced pluripotent stem cell lines from Huntington’s disease patients and controls. [Cell Stem Cell] Abstract | Press Release Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells Investigators report a molecular link between Wnt/β-catenin signaling and the expression of the telomerase subunit Tert. β-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cells expressing an activated form of β-catenin have long telomeres. [Science] Abstract | Press Release Identification of Embryonic Stem Cell-Derived Midbrain Dopaminergic Neurons for Engraftment Researchers demonstrated remarkable fate specificity of embryonic stem cell (ESC)-derived dopaminergic neurons and outline a sequential stage-specific ESC reporter line paradigm for in vivo gene discovery. [J Clin Invest] Full Article | Press Release Modeling Human Cortical Development In Vitro Using Induced Pluripotent Stem Cells Investigators showed that human induced pluripotent stem cells grown in suspension in the presence of rostral neuralizing factors can generate 3D structures containing polarized radial glia, intermediate progenitors, and a spectrum of layer-specific cortical neurons reminiscent of their organization in vivo. [Proc Natl Acad Sci USA] Abstract Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors into Functional Islets Capable of Treating Pre-Existing Diabetes in Mice Scientists developed a protocol to efficiently differentiate commercially available human embryonic stem cells in vitro into a highly enriched PDX1+ pancreatic progenitor cell population that further develops in vivo to mature pancreatic endocrine cells. [Diabetes] Abstract | Press Release Increasing Doublecortin Expression Promotes Migration of Human Embryonic Stem Cell-Derived Neurons Researchers tested whether increasing the expression of DCX in human embryonic stem cell derived neuronal progenitors would favorably alter their proliferation and migration. [Stem Cells] Abstract Directing Differentiation of Human Embryonic Stem Cells Towards Anterior Neural Ectoderm Using Small Molecules The authors demonstrated that pluripotent stem cells can be reproducibly and efficiently differentiated to PAX6+ and OCT4− cells with the use of potent small inhibitors of the bone morphogenic protein and Activin/Nodal pathways, and in animal-component free conditions, replacing the frequently used Noggin and SB431542. [Stem Cells] Abstract Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy Findings suggest that transplantation of genetically corrected mesoangioblast-like cells generated from induced pluripotent stem cells (iPSCs) from limb-girdle muscular dystrophy 2D patients may be useful for treating this type of muscular dystrophy and perhaps other forms of muscular dystrophy as well. [Sci Transl Med] Abstract | Press Release |