Extracellular Matrix Cell News Volume 11.28 | Jul 23 2020

May 12, 2022

Extracellular Matrix Cell News 11.28 | July 23 2020

Extracellular Matrix News by STEMCELL Technologies

Vol. 11.28 – 23 July, 2020

TOP STORY

Hyperglycemia Is Associated with Impaired Muscle Signaling and Aerobic Adaptation to Exercise

The authors’ data point to chronic hyperglycemia as a potential negative regulator of aerobic adaptation, in part, via glucose-mediated modifications of the ECM, impaired vascularization and aberrant mechanical signaling in muscle.
[Nature Metabolism]

Abstract

As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.

PUBLICATIONSRanked by the impact factor of the journal

ITLN1 Modulates Invasive Potential and Metabolic Reprogramming of Ovarian Cancer Cells in Omental Microenvironment

Scientists showed that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer. Further studies demonstrated that ITLN1 suppressed lactotransferrin’s effect on ovarian cancer cell invasion potential and proliferation by decreasing MMP1 expression and inducing a metabolic shift in metastatic ovarian cancer cells.
[Nature Communications]

Full Article

Dissemination of Ras^V12-Transformed Cells Requires the Mechanosensitive Channel Piezo

Investigators describe the morphologically distinct steps and the cellular events occurring over the course of RasV12-transformed cell dissemination. Ras^V12-transformed cells formed the Actin- and Cortactin-rich invasive protrusions that were important for breaching the ECM and visceral muscle.
[Nature Communications]

Full Article

A Collagen Vα1-Derived Fragment Inhibits FGF-2 Induced-Angiogenesis by Modulating Endothelial Cells Plasticity through Its Heparin-Binding Site

Researchers showed that HEPV bound to FGF2 through its heparin-binding site. Using in vitro and in vivo angiogenesis assays, they showed that HEPV but not the HEPV mutant at the heparin-binding site, inhibited FGF2-dependent angiogenesis.
[Matrix Biology]

Abstract

Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly

Scientists used a tension sensor based on ZO-1, a scaffolding protein that links the junctional membrane to the cytoskeleton, to determine if tight junctions carried a mechanical load.
[Cell Reports]

Full Article Graphical Abstract

3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis

Investigators employed mouse 3D cell culture models and imaging to study ex vivo the role of FGF ligands and the interplay of FGF signaling with epithelial growth factor and WNT signaling pathways in lung epithelial morphogenesis and differentiation.
[Frontiers in Cell and Developmental Biology]

Full Article

A 3D Engineered Scaffold for Hematopoietic Progenitor/Stem Cell Co-Culture In Vitro

To imitate the natural microenvironment, a 3D engineered scaffold for CD34⁺ cells co-culture was established via 3D bioprinting.
[Scientific Reports]

Full Article

Characterization of Multicellular Breast Tumor Spheroids using Image Data-Driven Biophysical Mathematical Modeling

Using MDA-MB-231 breast cancer multicellular tumor spheroids, researchers estimated biophysical parameters of cellular diffusion, rate of cellular proliferation, and cellular tractions forces.
[Scientific Reports]

Full Article

Therapeutic Targeting of 15-PGDH in Murine Pulmonary Fibrosis

Long-term pharmacologic 15-PGDH inhibition (PGDHi) was well-tolerated, reduced the severity of pulmonary fibrotic lesions and ECM remodeling, and improved pulmonary function in bleomycin-treated mice.
[Scientific Reports]

Full Article

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REVIEWS

Collagen: Quantification, Biomechanics and Role of Minor Subtypes in Cartilage

The authors introduce the roles of collagen subtypes and crosslinks and describe modern assays that enable a deep understanding of tissue physiology and disease states.
[Nature Reviews Materials]

Abstract

Neutrophil Diversity and Plasticity in Tumor Progression and Therapy

The authors surmise that neutrophils can provide tools to tailor current immunotherapy strategies and pave the way to myeloid cell-centred therapeutic strategies, which would be complementary to current approaches.
[Nature Reviews Cancer]

Abstract

INDUSTRY AND POLICY NEWS

Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]

Editorial

The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News]

Editorial

‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider]

Editorial

FEATURED EVENT

Hyperglycemia Is Associated with Impaired Muscle Signaling and Aerobic Adaptation to Exercise

ITLN1 Modulates Invasive Potential and Metabolic Reprogramming of Ovarian Cancer Cells in Omental Microenvironment

Dissemination of Ras^V12-Transformed Cells Requires the Mechanosensitive Channel Piezo

A Collagen Vα1-Derived Fragment Inhibits FGF-2 Induced-Angiogenesis by Modulating Endothelial Cells Plasticity through Its Heparin-Binding Site

Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly

3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis

A 3D Engineered Scaffold for Hematopoietic Progenitor/Stem Cell Co-Culture In Vitro

Characterization of Multicellular Breast Tumor Spheroids using Image Data-Driven Biophysical Mathematical Modeling

Therapeutic Targeting of 15-PGDH in Murine Pulmonary Fibrosis

Collagen: Quantification, Biomechanics and Role of Minor Subtypes in Cartilage

Neutrophil Diversity and Plasticity in Tumor Progression and Therapy

Science Money Slashed in EU’s €1.8-Trillion Budget Deal

The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

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