 | | Vol. 11.30 – 6 August, 2020 |
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| Researchers examined how regulation and function of gene products that provide the target epitopes for CD8+ T cell anti-tumor immunity influence therapeutic efficacy and resistance.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Experimentally manipulating stromal matrix with an anti– lysyl oxidase like-2 antibody in syngeneic orthotopic pancreatic ductal adenocarcinoma mouse models significantly decreased matrix content, led to lower tissue stiffness, lower contrast retention on computed tomography, and accelerated tumor growth, resulting in diminished overall survival.
[Journal of Clinical Investigation] |
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| Using secretome analyses, the authors revealed the extracellular accumulation of amyloidogenic proteins, i.e. premelanosome protein, in metastatic melanoma, together with proteins that assist amyloid maturation into fibrils.
[EMBO Reports] |
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| Researchers found that the temperature-regulated production of extracellular polymeric substance was necessary for morphological changes in biofilms.
[npj Biofilms and Microbiomes] |
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| Scientists investigated the effects of using gelatin- and fibrin-based hemostatic hydrogels as a scaffold on pulp regeneration in a minipig model.
[Scientific Reports] |
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| Researchers discovered that mechanical stimulation of integrin β1 led to the phosphorylation of AKT, an event which required the presence of integrin-linked kinase.
[Scientific Reports] |
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| Scientists analyzed the fusion process in connection with structure and mechanical properties of the spheroids from human somatic cells of different phenotypes: mesenchymal stem cells from the limbal eye stroma and epithelial cells from retinal pigment epithelium.
[Scientific Reports] |
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| Investigators present an experimental system based on 3D scaffold-based cortical neuron cultures in which they expressed the genetically encoded calcium indicator GCaMP6f to record neuronal activity at the millimeter-scale.
[iScience] |
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| The authors provide a concise overview of the contextual contribution of fibroblastic mesenchymal cells in physiology and disease and bring into focus emerging evidence for both their heterogeneity at the single-cell level and their tissue-specific, spatiotemporal functional diversity.
[Nature Immunology] |
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| Renal cell carcinoma is considered to be an immunogenic tumor but is known to mediate immune dysfunction in large part by eliciting the infiltration of immune-inhibitory cells, such as regulatory T cells and myeloid-derived suppressor cells, into the tumor microenvironment.
[Nature Reviews Nephrology] |
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| Scientists discuss the applications of 3D bioprinting in mimicking cancer microenvironment, their use in immunotherapy as prescreening tools, and overview of current bioprinted cancer models.
[npj Precision Oncology] |
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| Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)] |
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| October 20 – October 21
Virtual |
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| | The University of Tennessee Health Science Center (UTHSC) – Memphis, Tennessee, United States |
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| | Nanyang Technological University – Singapore, Singapore |
| | | University of Mississippi School of Pharmacy – Oxford, Mississippi, United States |
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| | Systimmune, Inc. – Redmond, Washington, United States |
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| | GlaxoSmithKline – Stevenage, United Kingdom |
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Cancer Stem Cell News
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Mammary Cell News
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