Extracellular Matrix Cell News Volume 11.32 | Aug 20 2020

    0
    21







    ECM 11.32 | Aug 20 2020


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 11.32 – 20 August, 2020
    TOP STORY

    Micro-Environmental
    Sensing by Bone Marrow Stroma Identifies IL-6 and TGFβ1 as Regulators of Hematopoietic Aging

    Researchers used bone marrow stromal cells as sensors of age-associated changes to the bone marrow microenvironment, and observed up-regulation of IL-6 and TGFβ signaling-induced gene expression in aged bone marrow stroma.
    [Nature Communications]

    Full Article


    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    Vulnerability
    of Progeroid Smooth Muscle Cells to Biomechanical Forces Is Mediated by MMP13

    Scientists developed a microfluidic chip formed by Hutchinson-Gilford Progeria Syndrome-Smooth muscle cells generated from induced pluripotent stem cells, to study their vulnerability to flow shear stress.
    [Nature Communications]

    Full Article

    Intercellular
    Communication Controls Agonist-Induced Calcium Oscillations Independently of Gap Junctions in Smooth Muscle Cells

    Investigators report the existence of a communication system among human smooth muscle cells that used mechanical forces to frequency modulate long-range calcium waves.
    [Science Advances]

    Full Article

    Stromal
    Cell Diversity Associated with Immune Evasion in Human Triple-Negative Breast Cancer

    Single‐cell RNA sequencing of five TNBCs revealed two cancer‐associated fibroblast (CAF) and two perivascular‐like (PVL) subpopulations. CAFs clustered into two states: the first with features of myofibroblasts and the second characterised by high expression of growth factors and immunomodulatory molecules.
    [EMBO Journal]

    AbstractGraphical Abstract

    Dendritic
    Cell Immune Potency on 2D and in 3D Collagen Matrices

    The authors studied how cell culture dimensionality (2D and 3D), and matrix density of 3D collagen matrices modulated differentiation and functions of dendritic cells (DCs). They found that expressed surface markers and secreted cytokines of both immature and mature DCs were generally higher in 2D culture, while they are regulated by matrix density in 3D culture.
    [Biomaterials Science]

    AbstractGraphical
    Abstract

    Pseudomonas aeruginosa
    Virulence Proteins Pseudolysin and Protease IV Impede Cutaneous Wound Healing

    Investigators indicated pseudolysin and protease IV secreted from biofilm producing and antibiotic resistant P. aeruginosa in the wound microenvironment produced both local and systemic effects, detrimental to the maintenance of tissue homeostasis.
    [Laboratory Investigation]

    Full Article

    Dodecin As Carrier Protein for Immunizations and Bioengineering Applications

    Researchers present the dodecin from Mycobacterium tuberculosis (mtDod) as a new scaffold protein. MtDod is a homododecameric complex of spherical shape, high stability and robust assembly, which allows the attachment of cargo at its surface.
    [Scientific Reports]

    Full Article

    Environmentally
    Controlled Magnetic Nano-Tweezer for Living Cells and Extracellular Matrices

    The magnetic tweezer technique can be used to analyze the mechanical properties of cells and extracellular matrices. The authors established a magnetic tweezer capable of measuring the linear and non-linear viscoelastic behavior of a wide range of soft matter in precisely controlled environmental conditions.
    [Scientific Reports]

    Full Article

    Collagen 24 α1 Is Increased in Insulin-Resistant Skeletal Muscle and Adipose Tissue

    Investigators developed a novel ECM-specific mass spectrometry-based proteomics technique to characterise the global view of the ECM changes in the skeletal muscle and liver of mice after high fat diet feeding.
    [International Journal of Molecular Sciences]

    Full Article


    Watch 'collaborating to accelerate COVID-19 research'
    REVIEWS

    New Preclinical Models for Angioimmunoblastic T-cell Lymphoma: Filling the GAP

    A complex network of interactions between angioimmunoblastic lymphoma (AITL) tumor cells and the various cells of the tumor microenvironment has impeded the study of AITL pathogenesis in vitro. The authors provide a summary of the pathology, the transcriptional profile and genetic and immune-phenotypic features of human AITL.
    [Oncogenesis]

    Full Article

    INDUSTRY AND POLICY NEWS

    Qu
    Biologics Initiates Phase 2 Study to Assess Activation of Anti-Cancer Immune Response in Colon Cancer

    Qu Biologics Inc. has announced approval from the Israeli Ministry of Health to proceed with their clinical trial of QBECO Site Specific Immunomodulator (SSI) in patients with colorectal cancer. The study, “Assessment of QBECO SSI on Immunological Parameters in the Tumor Microenvironment and Systemically in Patients with Colorectal Cancer” will enroll patients at the Sheba Medical Center with Principal Investigator, Dr. Gal Markel.
    [Qu Biologics Inc.]

    Press Release

    Dragonfly Therapeutics and Bristol Myers Squibb Announce Exclusive Global License for Dragonfly’s IL-12 Investigational Immunotherapy Program

    Bristol Myers Squibb and Dragonfly Therapeutics, Inc. have announced that they have entered into a definitive agreement under which Bristol Myers Squibb will be granted the global exclusive license to Dragonfly’s interleukin-12 (IL-12) investigational immunotherapy program, including its extended half-life cytokine DF6002. DF6002 is a monovalent IL-12 immunoglobulin Fc fusion protein proposed to achieve strong anti-tumor efficacy by establishing an inflammatory tumor microenvironment necessary for productive anti-tumor responses.
    [Bristol Myers Squibb]

    Press Release

    FEATURED EVENT

    Basement Membranes in Health and Disease

    September 1 – 2
    Virtual


    > See All Events

    JOB OPPORTUNITIES


    Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

    Pennsylvania State University – Philadelphia, Pennsylvania, United States

    Postdoc – Cancer Biology and Cancer Microenvironments

    University of Copenhagen – Copenhagen, Denmark

    Junior Research Group Leader Position – Experimental Oncology and Stem Cell Biology

    Heidelberg Institute for Stem Cell Technologies and Experimental Medicine – Heidelberg, Baden-Württemberg, Germany

    Basic Research Scientist – Tumor Microenvironment / Tumor Immunology

    Northwestern University – Chicago, Illinois, United States

    Intern
    – Regenerative Medicine in Pulmonary Hypertension

    United Therapeutics – Silver Spring, Maryland, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Extracellular Matrix News
    Archives Contact Us
    Extracellular Matrix News Twitter