| Vol. 11.32 – 20 August, 2020 |
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| Researchers used bone marrow stromal cells as sensors of age-associated changes to the bone marrow microenvironment, and observed up-regulation of IL-6 and TGFβ signaling-induced gene expression in aged bone marrow stroma. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed a microfluidic chip formed by Hutchinson-Gilford Progeria Syndrome-Smooth muscle cells generated from induced pluripotent stem cells, to study their vulnerability to flow shear stress. [Nature Communications] |
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| Investigators report the existence of a communication system among human smooth muscle cells that used mechanical forces to frequency modulate long-range calcium waves. [Science Advances] |
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| Single‐cell RNA sequencing of five TNBCs revealed two cancer‐associated fibroblast (CAF) and two perivascular‐like (PVL) subpopulations. CAFs clustered into two states: the first with features of myofibroblasts and the second characterised by high expression of growth factors and immunomodulatory molecules. [EMBO Journal] |
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| The authors studied how cell culture dimensionality (2D and 3D), and matrix density of 3D collagen matrices modulated differentiation and functions of dendritic cells (DCs). They found that expressed surface markers and secreted cytokines of both immature and mature DCs were generally higher in 2D culture, while they are regulated by matrix density in 3D culture. [Biomaterials Science] |
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| Investigators indicated pseudolysin and protease IV secreted from biofilm producing and antibiotic resistant P. aeruginosa in the wound microenvironment produced both local and systemic effects, detrimental to the maintenance of tissue homeostasis. [Laboratory Investigation] |
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| Researchers present the dodecin from Mycobacterium tuberculosis (mtDod) as a new scaffold protein. MtDod is a homododecameric complex of spherical shape, high stability and robust assembly, which allows the attachment of cargo at its surface. [Scientific Reports] |
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| The magnetic tweezer technique can be used to analyze the mechanical properties of cells and extracellular matrices. The authors established a magnetic tweezer capable of measuring the linear and non-linear viscoelastic behavior of a wide range of soft matter in precisely controlled environmental conditions. [Scientific Reports] |
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| Investigators developed a novel ECM-specific mass spectrometry-based proteomics technique to characterise the global view of the ECM changes in the skeletal muscle and liver of mice after high fat diet feeding. [International Journal of Molecular Sciences] |
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| A complex network of interactions between angioimmunoblastic lymphoma (AITL) tumor cells and the various cells of the tumor microenvironment has impeded the study of AITL pathogenesis in vitro. The authors provide a summary of the pathology, the transcriptional profile and genetic and immune-phenotypic features of human AITL. [Oncogenesis] |
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| Qu Biologics Inc. has announced approval from the Israeli Ministry of Health to proceed with their clinical trial of QBECO Site Specific Immunomodulator (SSI) in patients with colorectal cancer. The study, “Assessment of QBECO SSI on Immunological Parameters in the Tumor Microenvironment and Systemically in Patients with Colorectal Cancer” will enroll patients at the Sheba Medical Center with Principal Investigator, Dr. Gal Markel. [Qu Biologics Inc.] |
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| Bristol Myers Squibb and Dragonfly Therapeutics, Inc. have announced that they have entered into a definitive agreement under which Bristol Myers Squibb will be granted the global exclusive license to Dragonfly’s interleukin-12 (IL-12) investigational immunotherapy program, including its extended half-life cytokine DF6002. DF6002 is a monovalent IL-12 immunoglobulin Fc fusion protein proposed to achieve strong anti-tumor efficacy by establishing an inflammatory tumor microenvironment necessary for productive anti-tumor responses. [Bristol Myers Squibb] |
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| Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| University of Copenhagen – Copenhagen, Denmark |
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| Heidelberg Institute for Stem Cell Technologies and Experimental Medicine – Heidelberg, Baden-Württemberg, Germany |
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| Northwestern University – Chicago, Illinois, United States |
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| United Therapeutics – Silver Spring, Maryland, United States |
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