| Vol. 11.33 – 27 August, 2020 |
| |
|
|
| The authors review the complex mechanical behaviors of tissues and ECMs, discuss the effect of ECM viscoelasticity on cells, and describe the potential use of viscoelastic biomaterials in regenerative medicine. [Nature] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Active T-lymphocytes and decreased macrophages were present at residual disease and immunosuppressive cell states characterized progressive disease. Biological features revealed by scRNA-seq were biomarkers of clinical outcomes in independent cohorts. [Cell] |
|
|
|
| Scientists indicated that cadherins and ECM confinement cooperated to determine unjamming transitions and stepwise epithelial fluidization towards, ultimately, cell individualization. [Nature Cell Biology] |
|
|
|
| Electrochemiluminescence detection demonstrated that blood replacement therapy reduced cytokine storm in plasma and ELISA demonstrated reduced levels of matrix metalloproteinase-9 in the plasma and brains at different time points post-stroke. [Nature Communications] |
|
|
|
| Mechanistic investigations demonstrated that thioredoxin domain containing 5 (TXNDC5) promotes fibrogenesis by enhancing TGFβ1 signaling through direct binding with and stabilization of TGFBR1 in lung fibroblasts. [Nature Communications] |
|
|
|
| Scientists report an innovative tissue reinforcement strategy: a stratified scaffold containing osseous and tendinous tissue compartments attached through a continuous polyethylene glycol hydrogel interface. [Science Advances] |
|
|
|
| Researchers investigated the role of ECM remodeling by the collagenase MT1-MMP in conferring resistance of BRAF-mutant melanoma to BRAF inhibitor therapy. [Clinical Cancer Research] |
|
|
|
| Investigators characterized the effects of neoadjuvant chemotherapy (NAC) on the tumor-immune microenvironment, finding that triple-negative breast cancer was uniquely sensitive to the immunologic effects of NAC, and local increases in immune genes/sets were associated with improved outcomes. [Clinical Cancer Research] |
|
|
|
| Overexpression of miR-3614-5p attenuated non-small-cell lung cancer cell proliferation and invasion, and these effects could be partially reversed by reintroduction of phosphoglycerate mutase 1. [Cell Death & Disease] |
|
|
|
| Scientists found that the intracellular TGF-β signaling in adipocytes was inhibited by the transcriptional factor PPARγ, specifically by its ubiquitously expressed isoform PPARγ1. However, TGF-β led to adipocyte state loss when it was present simultaneously with another stimulus. [Scientific Reports] |
|
|
|
| Investigators developed iron oxide-loaded nanovaccines which, chemically programmed to integrate iron catalysis, drug delivery and tracking exploiting the characteristics of the tumor microenvironment, improved immunotherapy and activation of ferroptosis. [iScience] |
|
|
|
|
| The authors describe how the bioavailability of lactate differs in the microenvironments of tumors and inflammatory diseases compared with normal tissues, thus contributing to the establishment of specific immunological states in disease. [Nature Reviews Immunology] |
|
|
|
| The glomerular basement membrane (GBM) is composed of many unique components that are likely to be important for appropriate GBM function. The application of new imaging and proteomics technologies is enabling greater insight into GBM organization in health and disease. [Nature Reviews Nephrology] |
|
|
|
|
| Generex Biotechnology Corporation is pleased to announce that physicians at Yale University School of Medicine and the VA Connecticut Healthcare System have described the use of Excellagen® wound conforming collagen matrix as part of a hybrid surgical protocol to repair a femoral artery pseudoaneurysm. Femoral artery pseudoaneurysms are the most common complication following cardiac and peripheral angiographic procedures, with an incidence ranging from 2-6% following interventional procedures. [Generex Biotechnology Corp.] |
|
|
|
|
|
|
|
| Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States |
|
|
|
| Pennsylvania State University – Philadelphia, Pennsylvania, United States |
|
|
|
| United Therapeutics – Silver Spring, Maryland, United States |
|
|
|
| Nanyang Technological University – Singapore, Singapore |
|
|
|
| TU Dresden – Dresden, Germany |
|
|
|
|