Extracellular Matrix Cell News Volume 11.33 | Aug 27 2020

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    ECM 11.33 | Aug 27 2020


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 11.33 – 27 August, 2020
    TOP STORY

    Effects of Extracellular Matrix Viscoelasticity on Cellular Behavior

    The authors review the complex mechanical behaviors of tissues and ECMs, discuss the effect of ECM viscoelasticity on cells, and describe the potential use of viscoelastic biomaterials in regenerative medicine.
    [Nature]

    Full Article


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    Therapy-Induced
    Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

    Active T-lymphocytes and decreased macrophages were present at residual disease and immunosuppressive cell states characterized progressive disease. Biological features revealed by scRNA-seq were biomarkers of clinical outcomes in independent cohorts.
    [Cell]

    AbstractGraphical Abstract

    Cell-Cell
    Adhesion and 3D Matrix Confinement Determine Jamming Transitions in Breast Cancer Invasion

    Scientists indicated that cadherins and ECM confinement cooperated to determine unjamming transitions and stepwise epithelial fluidization towards, ultimately, cell individualization.
    [Nature Cell Biology]

    Abstract

    Blood Substitution Therapy Rescues the Brain of Mice from Ischemic Damage

    Electrochemiluminescence detection demonstrated that blood replacement therapy reduced cytokine storm in plasma and ELISA demonstrated reduced levels of matrix metalloproteinase-9 in the plasma and brains at different time points post-stroke.
    [Nature Communications]

    Full Article

    Fibroblast-Enriched
    Endoplasmic Reticulum Protein TXNDC5 Promotes Pulmonary Fibrosis by Augmenting TGFβ Signaling through TGFBR1 Stabilization

    Mechanistic investigations demonstrated that thioredoxin domain containing 5 (TXNDC5) promotes fibrogenesis by enhancing TGFβ1 signaling through direct binding with and stabilization of TGFBR1 in lung fibroblasts.
    [Nature Communications]

    Full Article

    Tough
    and Tunable Scaffold-Hydrogel Composite Biomaterial for Soft-to-Hard Musculoskeletal Tissue Interfaces

    Scientists report an innovative tissue reinforcement strategy: a stratified scaffold containing osseous and tendinous tissue compartments attached through a continuous polyethylene glycol hydrogel interface.
    [Science Advances]

    Full Article

    Targeting
    Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma

    Researchers investigated the role of ECM remodeling by the collagenase MT1-MMP in conferring resistance of BRAF-mutant melanoma to BRAF inhibitor therapy.
    [Clinical Cancer Research]

    Abstract

    Changes
    in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer

    Investigators characterized the effects of neoadjuvant chemotherapy (NAC) on the tumor-immune microenvironment, finding that triple-negative breast cancer was uniquely sensitive to the immunologic effects of NAC, and local increases in immune genes/sets were associated with improved outcomes.
    [Clinical Cancer Research]

    Abstract

    PGAM1,
    Regulated by miR-3614-5p, Functions as an Oncogene by Activating Transforming Growth Factor-β (TGF-β) Signaling in the Progression of Non-Small Cell Lung Carcinoma

    Overexpression of miR-3614-5p attenuated non-small-cell lung cancer cell proliferation and invasion, and these effects could be partially reversed by reintroduction of phosphoglycerate mutase 1.
    [Cell Death & Disease]

    Full Article

    TGF-β
    Is Insufficient to Induce Adipocyte State Loss without Concurrent PPARγ Downregulation

    Scientists found that the intracellular TGF-β signaling in adipocytes was inhibited by the transcriptional factor PPARγ, specifically by its ubiquitously expressed isoform PPARγ1. However, TGF-β led to adipocyte state loss when it was present simultaneously with another stimulus.
    [Scientific Reports]

    Full Article

    Chemically
    Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis

    Investigators developed iron oxide-loaded nanovaccines which, chemically programmed to integrate iron catalysis, drug delivery and tracking exploiting the characteristics of the tumor microenvironment, improved immunotherapy and activation of ferroptosis.
    [iScience]

    AbstractGraphical Abstract


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    REVIEWS

    Lactate Modulation of Immune Responses in Inflammatory versus Tumor Microenvironments

    The authors describe how the bioavailability of lactate differs in the microenvironments of tumors and inflammatory diseases compared with normal tissues, thus contributing to the establishment of specific immunological states in disease.
    [Nature Reviews Immunology]

    Abstract

    Complexities of the Glomerular Basement Membrane

    The glomerular basement membrane (GBM) is composed of many unique components that are likely to be important for appropriate GBM function. The application of new imaging and proteomics technologies is enabling greater insight into GBM organization in health and disease.
    [Nature Reviews Nephrology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Generex Biotechnology Subsidiary Olaregen Therapeutix Announces Publication on the Use of Excellagen® for Vascular Repair

    Generex Biotechnology Corporation is pleased to announce that physicians at Yale University School of Medicine and the VA Connecticut Healthcare System have described the use of Excellagen® wound conforming collagen matrix as part of a hybrid surgical protocol to repair a femoral artery pseudoaneurysm. Femoral artery pseudoaneurysms are the most common complication following cardiac and peripheral angiographic procedures, with an incidence ranging from 2-6% following interventional procedures.
    [Generex Biotechnology Corp.]

    Press Release

    FEATURED EVENT

    Cancer Research & Oncology 2020

    October 7 – 8
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Immune Microenvironment, Stem Cell, and Cancer

    Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States


    Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

    Pennsylvania State University – Philadelphia, Pennsylvania, United States

    Intern
    – Regenerative Medicine in Pulmonary Hypertension

    United Therapeutics – Silver Spring, Maryland, United States

    Postdoctoral
    Fellow – Biomaterial and Scaffold Design

    Nanyang Technological University – Singapore, Singapore

    Research
    Associate – Morphogen Dynamics

    TU Dresden – Dresden, Germany

    > See All Jobs

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