 | | Vol. 11.35 – 10 September, 2020 |
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| Using single-cell RNA sequencing and epigenetic profiling, scientists demonstrated that ‘reset’ vascular endothelial cells established an adaptive vascular niche that differentially adjusted and conformed to organoids and tumoroids in a tissue-specific manner.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed gut organoid cocultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed intestines. They demonstrated that murine and human ILC1 secreted transforming growth factor β1, driving expansion of CD44v6+ epithelial crypts.
[Nature Materials] |
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| How the interplay between tumor cells, Epstein-Barr virus (EBV), and the microenvironment contributes to nasopharyngeal carcinoma (NPC) progression and immune evasion remains unclear. Scientists performed single-cell RNA sequencing on ~104,000 cells from 19 EBV+ NPCs and 7 nonmalignant nasopharyngeal biopsies, simultaneously profiling the transcriptomes of malignant cells, EBV, stromal and immune cells.
[Cell Research] |
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| Adult cardiac fibroblasts were freshly isolated and cultured on ECM topographical mimetics for 72 hours. Aligned mimetics caused cardiac fibroblasts to elongate while randomly organized topographies induced circular morphology similar to the disparate myofibroblast morphologies measured in vivo.
[Circulation Research] |
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| Scientists identified ECM structures as previously unrecognized participants in the mechanism underlying diabetes remission induced by the central action of fibroblast growth factor 1.
[Nature Communications] |
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| Collagen-induced T cell exhaustion occured through the receptor LAIR1, which is upregulated following CD18 interaction with collagen, and induces T cell exhaustion through SHP-1.
[Nature Communications] |
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| Researchers determined the therapeutic potential of human (h)iPSCs in a mouse model of volumetric muscle loss. Muscles were subjected to excision to generate 30-40% muscle loss. Next, hiPSCs were differentiated toward skeletal myogenic progenitors and used with fibrin hydrogel to reconstruct the lost muscle.
[Molecular Therapy] |
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| The authors revealed that acidosis reduced vitamin D receptor (VDR) expression by downregulating peroxisome proliferator-activated receptor delta expression. Overexpression of VDR effectively suppressed the stemness and oxaliplatin resistance of cells in acidosis.
[Signal Transduction and Targeted Therapy] |
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| The impact of tumor secreted exosomes on immune function in the tumor environment was investigated using exosomes isolated from gastric cancer cell lines MKN-28, MKN-45, and SGC-7901.
[Scientific Reports] |
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| Researchers demonstrated that it was possible to quantitatively measure tumorigenic properties like growth of cell clump (or spheroid) over time, as well as single-cell invasion out of cell clump and into the surrounding ECM.
[Scientific Reports] |
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| Cells in different tissues, including endocrine cells in the pancreas, live in complex microenvironments that are rich in cellular and acellular components. The authors review current research on the interplay between the islet cellular and acellular components, and the role these components play in beta cell physiology and pathophysiology.
[Diabetologia] |
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| Investigators present the requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell-derived cardiomyocytes towards applications to tissue engineering (TE) hearts. Electrospinning is an attractive fabrication method for cardiac TE scaffolds because it produces fibers that demonstrate the optimal potential for mimicking the complex structure of the cardiac ECM.
[Bioengineering] |
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| Scientists analyze the role of proteoglycans on skin aging, influenced by the presence of glycosylated proteins. They are essential components that restore skin cells, providing hydration, maintaining hydration of the ECM and preventing the formation of wrinkles.
[International Journal of Cosmetic Science] |
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| Engitix Ltd. is developing a portfolio of programmes in fibrosis and solid tumours using its proprietary human ECM platform. They have entered into a licensing and collaboration agreement with Takeda Pharmaceutical Company Ltd. to discover and develop novel therapeutics for advanced fibrotic liver diseases, including non-alcoholic steatohepatitis.
[Engitix Ltd. ] |
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| | Sars-Fang Centre Ocean University of China – Qingdao, China |
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| | University of Washington – Seattle, Washington, United States |
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| | UCLA Jonsson Comprehensive Cancer Center – Los Angeles, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
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