 | | Vol. 11.36 – 17 September, 2020 |
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| The authors demonstrated that O-GlcNAc levels altered the sensitivity of primary human dermal fibroblasts in a collagen-matrix model of wound healing.
[Nature Chemical Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers introduced a resection and response-assessment approach for studying the tumor microenvironment before or shortly after treatment initiation to identify predictive biomarkers differentiating responders from nonresponders.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators showed that cells, as living systems, could harness a similar mechanism to migrate. Ligand-depleting migration was beneficial for cells to maintain adhesion on ligand-labile surfaces, and might also play a role in the migration of cancer cells, immune cells, and platelets that deplete adhesive ligands of the matrix.
[Current Biology] |
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| Scientists investigated the ECM profiles of patients with primary sclerosing cholangitis, primary biliary cholangitis (PBC) and autoimmune hepatitis to establish whether the diseases display differential patterns of ECM turnover.
[JHEP Reports] |
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| The authors found that chronic social defeat stress increased production of pro-inflammatory cytokines in lateral habenula associated with mobilization of monocytes and remodeling of extracellular matrix by increased matrix metalloproteinase activity.
[Neuropsychopharmacology] |
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| Researchers determined the role of MMP9 in maintaining genomic stability in colitis-associated cancer. Homozygous transgenic mice with constitutive-expression of MMP9 in the colonic epithelium with their wild-type littermates and stably transfected HCT116 cells with/without MMP9 were used for in vivo and in vitro experiments, respectively.
[Cell Death & Disease] |
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| Investigators determined the therapeutic efficacy of simultaneously targeting PI3K and HDAC pathways in lung myofibroblasts and cancer associated fibroblasts with a single agent and to evaluate biomarkers of treatment response.
[Cell Death & Disease] |
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| The authors report a patient with a loss-of-function of the secreted matricellular protein SPARC related modular calcium binding 2 (SMOC2) presenting severe oligodontia, microdontia, tooth root deficiencies, alveolar bone hypoplasia, and a range of skeletal malformations.
[Scientific Reports] |
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| A novel dual-crosslinked hydrogel system with fast dynamic crosslinks was developed by using methacrylate chitosan and aldehyde functionalized hyaluronate.
[Scientific Reports] |
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| Researchers demonstrated that EGF like repeats and discoidin I like domains protein 3 (EDIL3) expression levels were increased in paclitaxel-resistant breast and prostate cancer cells, and in subsets of high-grade breast and prostate tumors.
[Cell Death Discovery] |
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| Analysis of serum markers and bone histometric parameters confirmed that quercetin at both middle and high doses significantly decreased bone resorption-related markers collagen type I and tartrate-resistant acid phosphatase 5b, and increased bone formation-related marker procollagen 1 N-terminal propeptide as compared with hindlimb suspension group.
[Acta Pharmacologica Sinica] |
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| Scientists utilized 3D collagen matrices that allowed them to mimic the ECM stiffening during atherosclerosis by increasing collagen density.
[Bioengineering] |
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| Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
[Signal Transduction and Targeted Therapy] |
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| Scientists examined the role of the ECM and its associated factors in establishing a fertile soil from which individual tumor cells and micrometastases establish primary and secondary tumors. They focus on the role of the lung ECM in providing the architectural support for local metastases in lung cancer, and distant metastases in many solid tumors.
[Frontiers in Oncology] |
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| The authors focus on the pivotal roles of class I phosphoinositide 3-kinases (PI3Ks) in adaptive and innate immune cells, as well as other stromal components. They discuss the modulation by PI3K inhibitors of the tumor-supportive microenvironment, including eliminating the regulatory immune cells, restoring cytotoxic cells or regulating angiogenesis.
[Acta Pharmacologica Sinica] |
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| Immatics N.V. has provided an update on its fourth ACTengine® cell therapy program, IMA204. IMA204 is designed to address a novel target, COL6A3 exon 6, which is highly expressed in the stroma of a large number of solid tumors.
[Immatics Biotechnologies] |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Sars-Fang Centre Ocean University of China – Qingdao, China |
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| | University of Washington – Seattle, Washington, United States |
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| | UCLA Jonsson Comprehensive Cancer Center – Los Angeles, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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Cancer Stem Cell News
Cell Therapy News
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