 | | Vol. 11.37 – 24 September, 2020 |
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| Scientists introduced a three-dimensional bioprinting concept that used organoid-forming stem cells as building blocks that could be deposited directly into ECMs conducive to spontaneous self-organization.
[Nature Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified a gradient of increasing glucocorticoid receptor expression and signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes.
[Immunity] |
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| The authors presented thermoresponsive, smart material microgels that could be dispersed or injected into tissues and optically assayed to measure residual tissue elasticity after creep over several weeks.
[Nature Communications] |
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| Using micropatterned ECMs, researchers identified T-Plastin, one of the most ancient actin bundling proteins, as an actin stabilizer that promoted membrane protrusions and enabled bridging of ECM gaps.
[Nature Communications] |
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| Scientists describe a multicomponent hydrogel that recapitulates the 3D fibrous structure of interstitial tissue regions where idiopathic pulmonary fibrosis initiates. In contrast to findings on 2D hydrogels, myofibroblast differentiation in 3D was inversely correlated with hydrogel stiffness but positively correlated with matrix fibers.
[Science Advances] |
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| The authors introduced stimuli-responsive composite scaffolds fabricated by 3D laser lithography to simultaneously stretch large numbers of single cells in tailored 3D microenvironments.
[Science Advances] |
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| Despite strong tumor rejection, IL-2c unexpectedly lowered the tumor microenvironmental CD8+/Treg ratio. IL-2c reduced tumor microenvironmental Treg suppression and induced a fragile Treg phenotype, helping explain improved efficacy despite numerically increased Tregs without affecting Treg in draining lymph nodes.
[Cancer Research] |
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| Investigators designed hydrogel biomaterials as valve ECM mimics enabling the culture of valvular interstitial cells in either their quiescent fibroblast or activated myofibroblast phenotype in response to the local matrix stiffness.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| Scientists validated InflammaDry, a tear metalloproteinase 9 in situ immunoassay, and identified factors that could affect results or interpretation.
[Scientific Reports] |
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| Water, collagen, and proteoglycans determine articular cartilage functionality. If altered, susceptibility to premature degeneration is increased. This study investigated the effects of enzymatic proteoglycan depletion on cartilage functionality as assessed by advanced magnetic resonance imaging techniques under standardized loading.
[Scientific Reports] |
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| Scientists aimed to examine the feasibility of simultaneous imaging of extracellular collagen and inflammation for size-independent prediction of risk of rupture in murine abdominal aortic aneurysm.
[Scientific Reports] |
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| Researchers proposed an autoinduction (isopropyl β-D-thiogalactopyranoside (IPTG)-independent) system for recombinant proteins using E. coli as the expression host. They applied this bacterial host for autoinduction to the expression of recombinant proteins, including green fluorescence protein and an artificial ECM protein.
[Polymer Journal] |
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| The tumor microenvironment (TME) is a highly complex environment that surrounds tumors. Interactions between cancer cells/non-cancerous cells and cells/non-cell components in the TME support tumor initiation, development, and metastasis. Of the cell types in the TME, tumor-associated macrophages (TAMs) have gained attention owing to their crucial roles in supporting tumors and conferring therapy resistance.
[Trends in Pharmacological Sciences] |
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| The authors review a brief explanation of the structure, characteristics, applications, fabrication methods, and future outlooks of stimuli responsive hydrogels in tissue engineering and, in particular, 3D bioprinting.
[Journal of Controlled Release] |
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| Misonix, Inc. announced that it entered into an exclusive supply and distribution agreement with Gunze Limited for TheraGenesis® Bilayer Wound Matrix. TheraGenesis® is a proprietary, FDA cleared, porcine tendon derived collagen wound matrix with a silicone film layer used to treat trauma, burn and reconstructive wounds.
[Misonix, Inc.] |
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| May 18 – May 21, 2021
Hannover, Germany |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Zhejiang University – Zhejiang, China |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Sars-Fang Centre Ocean University of China – Qingdao, China |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
