 | | Vol. 11.38 – 1 October, 2020 |
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| Scientists unraveled a previously unexplored onco-fetal reprogramming of the tumor microenvironment, provided novel targets for therapeutic interventions in hepatocellular carcinoma, and open avenues for identifying similar paradigms in other cancers and disease.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Candidate cerebral palsy risk genes overlapped with neurodevelopmental disorder genes. Network analyses identified enrichment of Rho GTPase, ECM, focal adhesion and cytoskeleton pathways.
[Nature Genetics] |
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| Investigators constructed a switchable dual receptor chimeric antigen receptor-T cell whose activity was relied upon double antigens and was strictly controlled by a “switch” consisting of a PD-L1 blocking peptide conjugated to fluorescein isothiocyanate.
[Journal of the American Chemical Society] |
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| The hybrid cell membrane nanovesicles blocked CD47-signal regulatory protein alpha signaling axis while promoting M2-to-M1 repolarization within the tumor microenvironment, significantly preventing both local recurrence and distant metastasis in malignant melanoma models.
[Nature Communications] |
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| Researchers showed that inhibition of N6‐methyladenosine mRNA modification by depletion of methyltransferases enhanced response to anti‐PD‐1 treatment in pMMR‐MSI‐L colorectal cancer and melanoma.
[EMBO Journal] |
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| Transforming growth factor-β1 (TGF-β1) was increased in moderate-severe obstructive sleep apnea (OSA) patients vs. non-OSA or mild OSA patients with cutaneous melanoma.
[Scientific Reports] |
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| Scientists describe optimization of current methods and present new protocols for using human papillomavirus capsids to deliver non-viral DNA, thereby providing an alternative to DNA transfection. Using keratinocyte-generated ECMs could enhance infection efficiency in keratinocytes, hepatocytes and neuronal cells.
[Scientific Reports] |
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| The authors developed a minimal coarse-grained computational model to identify the physical principles of the assembly of collagen-mimetic molecules. They found that screened electrostatic interactions could drive the formation of collagen-like filaments of well-defined striped morphologies.
[Biophysical Journal] |
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| To better understand how biochemical and biophysical cues interact to regulate keratocyte activation and contractility, investigators cultured primary rabbit corneal keratocytes on flexible substrata of varying stiffness in the presence (or absence) of TGF-β1.
[Biophysical Journal] |
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| 3D collagen matrix was utilized to mimic the ECM of the tumor microenvironment. Scientists found that cancer-associated fibroblasts appeared to respond insensitively towards TGF-β1 in terms of cell proliferation and matrix remodeling when compared to normal human dermal fibroblasts.
[Gels] |
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| This study displayed histological and immunohistochemical analyses of a malignant tumor model developed from cancer stem cells converted from human induced pluripotent stem cells in a cancer microenvironment prepared from the conditioned medium of a pancreatic cancer cell line.
[Acta Histochemica] |
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| Researchers showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.
[iScience] |
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| WNT–β-catenin signaling is involved in chronic kidney disease-associated vascular calcification and mineral bone disease. The WNT–β-catenin pathway is tightly regulated, for example, by proteins of the Dickkopf family.
[Nature Reviews Nephrology] |
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| Cardiovascular cells derived from muscular dystrophy patients’ induced pluripotent stem cells are well suited to mimic dystrophin-associated cardiomyopathy and hold great promise for the development of future fully effective therapies. This article conveys the realities of employing precision disease models of dystrophin-associated cardiomyopathy.
[International Journal of Molecular Sciences] |
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| Kuur Therapeutics, has announced the treatment of the first patients in its ANCHOR phase I study of KUR-502, an allogeneic CAR-NKT therapy. KUR-502 is engineered with a CD19-specific CAR construct that secretes the cytokine IL-15, shown in nonclinical studies to increase the persistence of CAR-NKT cells and improve their efficacy within the immunosuppressive tumor microenvironment.
[Kuur Therapeutics] |
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| FUJIFILM Irvine Scientific, Inc. has announced that it has become the exclusive, worldwide distributor of cellnest®, a recombinant peptide attachment substrate that provides optimal adhesion and proliferation of stem cells in chemically defined, animal component-free conditions. Attachment substrates mimic the ECM and allow for the adhesion, expansion, and potential differentiation of stem cells.
[FUJIFILM Irvine Scientific, Inc.] |
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| Jul 11 – 16, 2021
New London, New Hampshire, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | University of British Columbia- Vancouver, British Columbia, Canada |
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| | Sars-Fang Centre Ocean University of China – Qingdao, China |
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Cancer Stem Cell News
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