 | | Vol. 11.43 – 5 November, 2020 |
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| Modeling microenvironmental influences in cell culture has been challenging, and technical limitations have hampered the comprehensive study of tumor-specific metabolism in vivo. To systematically interrogate metabolic vulnerabilities in pancreatic ductal adenocarcinoma, scientists employed parallel CRISPR-Cas9 screens using in vivo and in vitro systems.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| When adenoviral-Mohawk-transduced MSCs were seeded on TGF-β3-conjugated decellularized meniscus scaffold (DMS) and inserted into experimental tears in meniscus explants, they increased glycosaminoglycan content, ECM interconnectivity, cell infiltration into the DMS, and improved biomechanical properties.
[Science Translational Medicine] |
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| Classic Hodgkin lymphoma (cHL) is the cancer type most susceptible to anti-programmed-death-receptor-1 (PD1) treatment and characterized by scarce Hodgkin and Reed-Sternberg cells perpetuating a unique tumor microenvironment. Scientists identified a unique, very early histologic response pattern to anti-PD1 therapy in cHL suggestive for withdrawal of pro-survival factors rather than induction of an adaptive anti-tumor immune response as main mechanism of action.
[Blood] |
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| Human skin provides both physical integrity and immunological protection from the external environment using functionally distinct layers, cell types and ECM. The authors combined advanced tissue dissection methods, flow cytometry and state-of-the-art proteomics to describe a spatially-resolved quantitative proteomic atlas of human skin.
[Nature Communications] |
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| Researchers hypothesized that head and neck squamous cell carcinoma (HNSCC) recurrent tumors successfully evade anti-tumor immune response and aimed to reveal tumor immune microenvironment changes of primary tumors.
[Clinical Cancer Research] |
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| The authors established an immunocompetent syngeneic pancreatic ductal adenocarcinoma model, and investigated the effect of oncolytic herpes simplex virus-1 on the composition of tumor microenvironment immune cells.
[Molecular Therapy] |
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| The balance between immune-stimulatory and immune-suppressive mechanisms in the tumor microenvironment was associated with tumor rejection and could predict the efficacy of immune checkpoint-inhibition therapies.
[British Journal of Cancer] |
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| Scientists showed that cancer-associated fibroblast-secreted exosomal miR-423-5p promoted chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β pathway.
[Experimental and Molecular Medicine] |
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| Researchers demonstrated the immune response mediated by an adeno-associated viruse (AAV) vector in a mouse model. Mice were infected intravenously with 4×10ˆ12 cp/kg of AAV8 and the ensuing immune response was analyzed using intravital microscopy, over a period of weeks.
[Molecular Therapy-Methods & Clinical Development] |
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| The authors demonstrated that xenogeneic placental ECM, implanted heterotopically (representing a biologically critical and challenging microenvironment), induced local inflammatory reactions similar to the allogeneic muscle ECM, implanted orthotopically.
[Connective Tissue Research] |
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| By using a human skin equivalent (HSE), the horizontal tension-force balance of the dermal layer was found to clearly improve HSE characteristics, such as the physical relationship between cells and the ECM.
[Communications Biology] |
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| When normal tissue architecture is disrupted by cancer growth and invasion, microarchitecture is altered. Stromal and cancer cells and ECM adopt new organization. This changes the interactions between an individual cell and its surrounding matrix and cells, which affects signaling pathways associated with invasion and metastasis.
[Science] |
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| The authors explore the roles of mitochondria in the four defined ‘hallmarks of metastasis’: motility and invasion, microenvironment modulation, plasticity and colonisation.
[British Journal of Cancer] |
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| Scientists critically review seminal and recent articles on the signaling mechanisms by which each stromal element promotes epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma.
[Signal Transduction and Targeted Therapy] |
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| CytomX Therapeutics, Inc. announced the treatment of the first patient in the Phase II expansion study of CX-2029, an anti-CD71 Probody® drug conjugate. CX-2029 is under evaluation as monotherapy in various cancers. Probody therapeutics are designed to remain inactive until they are activated by proteases in the tumor microenvironment.
[CytomX Therapeutics, Inc.] |
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| April 9 – April 14, 2021
Washington, DC, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Edward Via College of Osteopathic Medicine – Blacksburg, Virginia, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, Zhejiang, China |
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| | Moores Cancer Center, UC San Diego – La Jolla, California, United States |
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Cancer Stem Cell News
Cell Therapy News
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