| Vol. 11.47 – 3 December, 2020 |
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| PAK4 knockout induced adhesion protein re-expression in endothelial cells, reduced vascular abnormalities, improved T cell infiltration and inhibits glioblastoma growth in mice. [Nature Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists profiled lysyl hydroxylase-mediated and lysyl oxidase-mediated collagen crosslinks and quantified the greatest abundance of total and complex collagen crosslinks in aggressive human breast cancer subtypes with the stiffest stroma. [Nature Materials] |
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| By modulating fibroblast growth factor, transforming growth factor β, and WNT pathways, the authors derived pluripotent stem cells from mice, horses, and humans that were permissive for direct primordial germ cell-like cell induction in vitro and were capable of contributing to intra- or inter-species chimeras in vivo. [Cell Stem Cell] |
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| Using two distinct mouse lines, scientists found that increasing contractility of differentiated cells resulted in non-cell-autonomous hyperproliferation of stem cells and prevented their commitment to a hair follicle lineage. [Cell Stem Cell] |
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| To generate spatially-resolved tumor and immune cell data at single cell resolution, investigators developed two quantitative multiplex immunofluorescence assays to interrogate myeloid cells and macrophages in the pancreatic ductal carcinoma tumor microenvironment. [Clinical Cancer Research] |
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| Hepatic progenitor cells either derived in microfluidics or exposed to exogenous ECM stimuli showed a significantly higher potential of forming hepatic organoids that could be rapidly expanded for several passages and further differentiated into functional hepatocytes. [Cell Reports] |
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| Researchers evaluated the potential role of macrophage-derived small extracellular vesicles (sEVs) in biomimetic mineralized collagen-mediated endogenous bone regeneration in vivo and in vitro. Macrophage-derived sEVs were involved in intrafibrillarly mineralized collagen (IMC)-mediated endogenous bone regeneration in vivo, and IMC-sEVs facilitated mesenchymal stem cell osteogenesis through the Smad/1/5/9 pathway. [International Journal of Oral Science] |
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| Scientists revealed that TNF-α promoted the release of nitric oxide and IL-6 by L929 fibroblast cells, but co-treatment with activin A attenuated these effects. In contrast, activin A induced cell migration and increased the production of tissue fibrosis-related TGF-β1 and fibronectin, while TNF-α inhibited these function changes of L929 cells induced by activin A. [Scientific Reports] |
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| The authors illustrated that canine dental pulp stem cells contained superior osteogenicity comparing with canine bone marrow-derived mesenchymal stem cells regarding alkaline phosphatase activity, matrix mineralization, and osteogenic marker expression. [Scientific Reports] |
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| The microenvironment possesses a strong impact on the tumor chemoresistance when cells bind to components of the ECM. Scientists elucidated the signaling pathways of cisplatin resistance in W1 ovarian cancer cells binding to collagen type 1 and signaling interference with constitutive cisplatin resistance in W1CR cells to discover the targets for sensitization. [International Journal of Molecular Sciences] |
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| Scientists combine recent and older data on organization of the dermal-epidermal junction, its mechanical properties and role in mechanotransduction, its involvement in regeneration, and its fate during the aging process. [Biomolecules] |
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| The authors explore the synergistically collective behaviors of multiple aggregation-induced emission (AIE) units in ordered arrays by investigating scaffolding materials ranging from discrete cage compounds to infinite crystalline frameworks. [Matter] |
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| Turnstone Biologics Corp. has enrolled the first patients in a Phase I/IIa clinical trial of its RIVAL-01/TAK-605 candidate in patients with solid tumors, conducted in collaboration with Takeda Pharmaceutical Company Limited. RIVAL-01 consists of Turnstone’s proprietary oncolytic vaccinia virus backbone encoding transgenes for Flt3 ligand, anti-CTLA-4 antibody, and IL-12 cytokine, purposefully designed to work together to drive immune activity and re-program the microenvironment to be best suited for tumor eradication. [Turnstone Biologics Corp. (Businesswire, Inc.)] |
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| NanoString Technologies, Inc. has announced the development of a spatial molecular imaging platform, a next generation solution for multiplexed analysis of RNA and protein expression for individual cells within a tissue sample. The GeoMx® Digital Spatial Profiler enables multi-cellular analysis at the whole transcriptome level to elucidate the behavior of populations of cells, such as those within a tumor or the tumor microenvironment. [NanoString Technologies, Inc.] |
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| May 30 – June 4, 2021 Castelldefels, Spain |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United Statess |
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| University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Stanford University – Stanford, California, United States |
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| Edward Via College of Osteopathic Medicine – Blacksburg, Virginia, United States |
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