 | | Vol. 11.49 – 17 December, 2020 |
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| Scientists showed that embedding of embryonic stem cell-derived aggregates in an ECM surrogate generated more advanced in vitro models that were formed in a process highly analogous to embryonic development.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors describe two protocols for the construction of responsive and activable nanomedicines that regulate the tumor microenvironment.
[Nature Protocols] |
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| Researchers developed facile all-aqueous microfluidic approaches for producing perfusable hydrogel microtubes with diverse biomimetic sizes and shapes.
[Nature Protocols] |
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| Investigators identified epithelial-mesenchymal hybrid cells, capable of long-term expansion in vitro, and able to reconstitute an anatomic phenocopy of the native thymus, when combined with thymic interstitial cells and a natural decellularized ECM obtained by whole thymus perfusion.
[Nature Communications] |
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| The authors report that activating transcription factor 3 (ATF3) was over-expressed in mice and human fibrotic livers, in activated hepatic stellate cells and injured hepatocytes.
[Cell Death & Disease] |
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| Scientists explored a variant-directed chemical biology approach to reverse the lost function of tumor suppressors using SMAD4 as an example. SMAD4, a central mediator of the TGF-β pathway, is recurrently mutated in many tumors.
[Cell Chemical Biology] |
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| Human umbilical cord-mesenchymal stem cells were cultured on polyacrylamide hydrogels with stiffnesses corresponding to Young’s modulus of 13-16kPa and 62-68kPa which mimic the stiffnesses of healthy heart tissue and fibrotic myocardium.
[Aging] |
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| The authors present a novel and reliable system for culturing the human gut microbiota in vitro. An electrospun gelatin structure was biofabricated as scaffold for microbial growth.
[Scientific Reports] |
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| Researchers tested the ability of the stem cells derived from bone marrow, dental pulp and dental apical papilla to engineer pericyte-supported vascular capillaries when encapsulated along with human umbilical vein endothelial cells in gelatin methacrylate hydrogel.
[Scientific Reports] |
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| A co-culture collagen gel model of the ligament was used to evaluate effects of collagenase on microscale changes to the collagen fibers and embedded neurons.
[Scientific Reports] |
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| An overview of current 3D‐bioprinted glioblastoma (GBM) and blood-brain barrier (BBB) models is provided, elaborating on the microenvironmental compositions of GBM and BBB, relevant biomaterials to mimic the native tissues, and bioprinting strategies to implement the model fabrication.
[Advanced Materials] |
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| Scientists review colon ECM physical properties at physiological and pathological states and their bioengineered in vitro reproduction applications to intestinal stem cell studies.
[Cells] |
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| MTF Biologics® has received the coveted American Podiatric Medical Association (APMA) Seal of Approval for two MTF Biologics wound care tissues, SomaGen® Meshed, Allograft Dermal Matrix and Leneva®, Allograft Adipose Matrix. To receive the seal, both tissues were reviewed by a panel of experienced APMA podiatric physicians.
[MTF Biologics®] |
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| Metacrine, Inc. has reported preliminary results from its Phase I trial of MET642, a farnesoid X receptor (FXR) agonist being developed for the treatment of non-alcoholic steatohepatitis and inflammatory bowel disease. Findings showed that treatment with MET642 was safe and generally well-tolerated and demonstrated a sustained pharmacokinetic profile and robust FXR target engagement after 14 days of daily oral dosing in healthy volunteers.
[Metacrine, Inc.] |
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| January 7 – 8, 2021
Virtual |
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| | Duke University – Durham, North Carolina, United States |
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| | Karlsruhe Institute of Technology – Karlsruhe, Baden-Württemberg, Germany |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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Cancer Stem Cell News
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