| Vol. 12.01 – 14 January, 2021 |
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| Scientists examined the T cell-intrinsic role of Activin-A, a TGF-β superfamily member closely related to TGF-β1, in pathogenic Th17 cell differentiation. Activin-A expression was increased in individuals with relapsing-remitting multiple sclerosis and in mice with experimental autoimmune encephalomyelitis. [Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The local soft spots created by liver cancer stem cells could enhance stemness and drug resistance and provide a route of escape to facilitate hepatocellular carcinoma metastasis. [Advanced Science] |
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| The authors describe that the stemness and differentiation potential of cancer stem cells were enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition and ECM remodeling to form the specific mechanism of vasculogenic mimicry. [Molecular Cancer] |
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| Investigators focus on TGFβ, a well-characterized family member that has a dichotomous role in cancer progression, acting in early stages as a tumor suppressor and in late stages as a tumor promoter. [Signal Transduction and Targeted Therapy] |
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| Researchers revealed a mechanism by which the nucleus mechanically generates migration paths for mesenchymal stem cells (MSCs) in confining microenvironments. MSCs migrated robustly in nanoporous, confining hydrogels that were viscoelastic and plastic but not in hydrogels that were more elastic. [Science Advances] |
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| Scientists present an in vitro model of the peripheral nervous system by establishing a coculture model of motor neurons and Schwann cells in a 3D environment in a microengineered ECM hydrogel scaffold. [NPG Asia Materials] |
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| The authors suggested that the hypoxic microenvironment stimulates glioma to generate miR-1246- and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy. [Experimental and Molecular Medicine] |
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| Transcriptional profiling of IL-33-deficient kidneys 24 hours after ligation revealed enhanced expression of fibrogenic genes and enrichment of gene sets involved in ECM formation and remodeling. [Scientific Reports] |
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| Results of flow property, shape fidelity, scaffold stability and biocompatibility of H4-RGD suggest that the proposed hydrogel could be considered for 3D cell bioprinting and also for in vitro tumor microenvironment development for high throughput screening of various anti-cancer drugs. [Scientific Reports] |
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| Electrospun fibrous scaffolds combined with bioactive factors could display impressive performance as an ideal wound dressing, since they can mimic the composition and physicochemical properties of the ECM. The authors fabricated a new composite biomaterial for wound healing, using a rat model for experimental evaluation. [Scientific Reports] |
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| Nature uses ECM scaffolds to organize biominerals into hierarchical structures over various length scales. This has inspired the design of biomimetic mineralization scaffolds, with DNA nanostructures being among the most promising. DNA nanotechnology makes use of molecular recognition to controllably give 1D, 2D and 3D nanostructures. [Nature Reviews Chemistry] |
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| The authors describe that the stemness and differentiation potential of cancer stem cells were enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition and ECM remodeling to form the specific mechanism of vasculogenic mimicry. [Molecular Cancer] |
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| Scienists focus on TGFB1/INHBA homodimer/Nodal-SMAD2/3 signaling network in pancreatic cancer as a pivotal central node which regulates multiple key mechanisms involved in the development of chemoresistance, including enhancement of the stem cell-like properties and tumorigenicity of pancreatic cancer cells, mediating cooperative interactions between pancreatic cancer cells and the surrounding stroma as well as regulating the deposition of ECM proteins within the tumor microenvironment. [Molecular Therapy] |
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| Adocia announced it has developed a hydrogel scaffold that hosts and protects pancreatic β cells for replacement of the missing cells of people with type 1 diabetes. [Adocia] |
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| February 3 – 23, 2021 Virtual |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| University of Florida – Gainesville, Florida, United States |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| Duke University – Durham, North Carolina, United States |
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